Balance Problems, Paralysis, and Angina as Clinical Markers for Severity in Major Depression

Qi, Bill; MacDonald, Kellie; Berlim, Marcelo T.; Fielding, Allan; Lis, Eric; Low, Nancy; Richard‐Devantoy, Stéphane; Tourjman, Valérie; Turecki, Gustavo; Trakadis, Yannis

doi:10.3389/fpsyt.2020.567394

Cited by 4 publications

(4 citation statements)

References 28 publications

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“…Later studies on MSA patients also found similar results with the finding that MSA patients with longer disease duration and severer disease conditions tended to have a worse psychiatric status, especially regarding depression ( 75 , 80 ). Prior studies have also reported those two characteristics as potential risk factors contributing to the increased severity of depression observed among patients with other neurodegenerative diseases ( 97 ). To summarize, it is reasonable to propose that MSA patients, especially female patients and those with longer disease duration and severer disease conditions may be more likely to suffer from depression.…”

Section: Clinical Features Of Msa-related Depressionmentioning

confidence: 94%

Depression in multiple system atrophy: Views on pathological, clinical and imaging aspects

Pan

Chen

et al. 2022

Front. Psychiatry

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Multiple system atrophy (MSA) is a common atypical parkinsonism, characterized by a varying combination of autonomic, cerebellar, and pyramidal systems. It has been noticed that the patients with MSA can be accompanied by some neuropsychiatric disorders, in particular depression. However, there is limited understanding of MSA-related depression. To bridge existing gaps, we summarized research progress on this topic and provided a new perspective regarding pathological, clinical, and imaging aspects. Firstly, we synthesized corresponding studies in order to investigate the relationship between depression and MSA from a pathological perspective. And then, from a clinical perspective, we focused on the prevalence of depression in MS patients and the comparison with other populations. Furthermore, the associations between depression and some clinical characteristics, such as life quality and gender, have been reported. The available neuroimaging studies were too sparse to draw conclusions about the radiological aspect of depression in MSA patients but we still described them in the presence of paper. Finally, we discussed some limitations and shortcomings existing in the included studies, which call for more high-quality basic research and clinical research in this field.

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Section: Clinical Features Of Msa-related Depressionmentioning

confidence: 94%

Depression in multiple system atrophy: Views on pathological, clinical and imaging aspects

Pan

Chen

et al. 2022

Front. Psychiatry

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“…For item 8, as poor balance is associated with depressive symptoms, we focused on developing user’s balance and proprioceptive neuromuscular system. Qi and colleagues [ 56 ] showed that muscular paralysis and balance problems were significantly associated with increased severities of depression (odds ratio 13.5 and 2.9, respectively), and recommended that testing for changes in balance and muscular paralysis could be useful biomarkers for assessing depression severity that could be administered regularly for monitoring patients with major depressive disorders [ 56 ]. Similarly, the “gait and brain study” showed that depressive symptoms may amplify balance problems in older adults with mild cognitive impairment during sensorimotor challenges [ 57 ].…”

Section: Methodsmentioning

confidence: 99%

Applying Gamification Principles and Therapeutic Movement Sequences to Design an Interactive Physical Activity Game: Development Study

Kim¹,

O’Sullivan²,

Chung³

2022

JMIR Serious Games

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Background Depression is a severe illness that has accelerated with the spread of COVID-19 and associated lockdowns. As a result, reported physical activity has substantially decreased, further increasing depressive symptoms. Objective This study aims to explain the use of gamification principles to develop content for an interactive physical activity game for depression based on clinically proven depression diagnostic criteria. Methods We discuss related work in this field, the game design framework, the users’ depression severity, how we customize the contents accordingly, the gradual progression of the game to match exercise principles, and user flow optimization. Results We provide a brief description of each of the games developed, including instructions on how to play and design aspects for flow, audio, and visual feedback methods. Exergames (interactive physical activity–based games) stimulate certain physical fitness factors such as improving reaction time, endurance, cardiovascular fitness, and flexibility. In addition, the game difficulty progresses based on various factors, such as the user’s performance for successful completion, reaction time, movement speed, and stimulated larger joint range of motions. Cognitive aspects are included, as the user has to memorize particular movement sequences. Conclusions Mental health issues are linked to behavior and movement; therefore, future physical activity–based interactive games may provide excellent stimulation for inducing user flow, while physical activity can help train various physical fitness factors linked to depression.

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“…Some shortcomings in this study should be mentioned here: (i) the number of included participants was relatively small, which made our findings needing future studies to validate further and support ( 34 , 35 ); (ii) all of the included BPPV and VM patients were from the same place, which could limit the applicability of our results; (iii) we only explored the sleep disorders of two kinds of neuropsychiatric disorders; neurotologists should further investigate the sleep problems of patients with other neuropsychiatric disorders, such as depression ( 36 – 38 ); (iv) sex and age were two mainly confounding factors in life science researches ( 39 – 41 ). In this study, limited by the relatively small sample size, we did not analyze whether there were sex- or age-specific sleep disorders in patients with VM or BPPV; this point was worthy of further investigations.…”

Section: Limitationsmentioning

confidence: 98%

Differences of Sleep Disorders Between Vestibular Migraine and Benign Paroxysmal Positional Vertigo

et al. 2021

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Introduction: Sleep disorders can affect the overall health and quality of life of patients. This study was conducted to compare the differences of sleep disorders in vestibular migraine (VM) patients and benign paroxysmal positional vertigo (BPPV) patients.Methods: VM patients, BPPV patients, and healthy controls (HCs) were recruited. Pittsburgh sleep quality index and polysomnography monitoring were used as subjective and objective, respectively, evaluation methods to evaluate the sleep quality of participants in the latest month.Results: Fifty-seven BPPV patients, 48 VM patients, and 42 HCs were included in this study. There were 79.16% VM patients, 54.39% BPPV patients, and 14.28% HCs with sleep disorders. The difference in the incidence rate of sleep disorders was significant between VM patients and BPPV patients (p = 0.008) and significantly higher in both the VM group (p < 0.00001) and BPPV group (p = 0.00004) than in the HC groups (14.28%). Compared with BPPV patients, the VM patients had the significantly lower sleep efficiency (p < 0.001) and N3 (p < 0.001) and the significantly higher time of wake-up after sleep onset (p < 0.001), N1 (p < 0.001), and N2 (p < 0.001). Meanwhile, the VM patients had significantly higher incidence rates of severe obstructive sleep apnea hypoventilation syndrome (p = 0.001) and periodic leg movement in sleep (p = 0.016).Conclusion: The incidence rate of sleep disorders was significantly higher in both VM and BPPV patients than in the HC groups. To improve the curative effects, clinicians should pay more attention to the comorbidity of sleep disorders in treating VM and BPPV.

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Balance Problems, Paralysis, and Angina as Clinical Markers for Severity in Major Depression

Cited by 4 publications

References 28 publications

Depression in multiple system atrophy: Views on pathological, clinical and imaging aspects

Depression in multiple system atrophy: Views on pathological, clinical and imaging aspects

Applying Gamification Principles and Therapeutic Movement Sequences to Design an Interactive Physical Activity Game: Development Study

Differences of Sleep Disorders Between Vestibular Migraine and Benign Paroxysmal Positional Vertigo

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