Baicalin lipid nanocapsules for treatment of glioma: characterization, mechanistic cytotoxicity, and pharmacokinetic evaluation

Ibrahim, Alaa; Gaber, Sara A. Abdel; Kabil, Mohamed Fawzi; Ahmed‐Farid, Omar A.; Hirsch, A.; El‐Sherbiny, Ibrahim M.; Nasr, Maha

doi:10.1080/17425247.2022.2139370

Cited by 10 publications

(3 citation statements)

References 67 publications

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“…The intestinal flora has been found to rapidly convert baicalin to baicalein and play an important role in improving blood concentration ( Wang et al, 2015 ). Due to the development of nanotechnology, researchers have found that combining baicalin and baicalein with nano transmitters can significantly increase their bioavailability in vivo and enhance their anti-tumor activity ( Ibrahim et al, 2022 ; Zheng F. et al, 2023 ).Moreover, new formulations such as solid dispersions, liposome formulations, phospholipid complexes, β-cyclodextrin inclusions, and metal complexes provide new technical support to enhance the anti-tumor activity of baicalin and baicalein ( Long et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Multiple roles of baicalin and baicalein in the regulation of colorectal cancer

Wang,

Wu,

Peng

et al. 2024

Front. Pharmacol.

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The prevalence of colorectal cancer is increasing worldwide, and despite advances in treatment, colorectal cancer (CRC) remains in the top three for mortality due to several issues, including drug resistance and low efficiency. There is increasing evidence that baicalin and baicalein, novel small molecule inhibitor extracts of the Chinese herb Scutellaria baicalensis, have better anti-colorectal cancer effects and are less likely to induce drug resistance in cancer cells. The present review article explains the anti-proliferative properties of baicalin and baicalein in the context of against CRC. Additionally, it explores the underlying mechanisms by which these compounds modulate diverse signaling pathways associated with apoptosis, cell proliferation, tumor angiogenesis, invasion, metastasis, and tumor microenvironment. Moreover, this review article highlights the inhibitory effect of colorectal inflammatory-cancer transformation and the near-term therapeutic strategy of using them as adjuvant agents in chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Multiple roles of baicalin and baicalein in the regulation of colorectal cancer

Wang,

Wu,

Peng

et al. 2024

Front. Pharmacol.

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“…Afterward, 70 μL of SRB solution (0.4% w/v) was mixed and left at RT for 10 min in the dark. Plates were cleaned 3 times with 1% acetic acid and air-dried for 24 h. The protein-bound (SRB) stain was then solubilized in 150 μL of TRIS (10 mM), and the optical density was recorded at 540 nm via (the BMG LABTECH-FLUO star Omega microplate reader, Ortenberg, Germany). , …”

Section: Methodsmentioning

confidence: 99%

Synthesis of Cross-Linked and Sterilized Water-Soluble Electrospun Nanofiber Biomatrix of Streptomycin-Imbedded PVA/CHN/β-CD for Wound Healing

Mohsen,

Abdel Gaber,

Shoueir

et al. 2024

ACS Omega

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The diagnosis and prognosis of chronic wounds are demanding and require objective assessment. Because of their potential medicinal applications, the syntheses of biopolymeric chitosan (CHN) structure and PVA-based mixed electrospun nanofibers with biomimetic features were thoroughly investigated. This study created different formulas, including a guest molecule and capping agent, using supporting PVA as a vehicle. CHN was used as a biomodifier, and beta-cyclodextrin (ß-CD) as a smoother and more efficiently entraps streptomycin (STP) compared with the silver sheet wound dressing. The relevant analyses showed that the size distribution increased with the incorporation of PVA, CHN, and ß-CD to 120.3, 161.9, and 192.02 nm. The webs boosted particle size and released content stability to 96.4% without compromising the nanofiber structure. Examining the synergistic effects of the PVA/CHN/STP/ß-CD nanoformulation against pathogenic strains of S. aureus, P. aeruginosa, and Aspergillus niger, clean zones were 47 ± 3.4, 45 ± 3.0, and 49 ± 3.7 mm were produced. PVA/CHN/STP/ß-CD formula exhibited a 98.9 ± 0.6% cell viability and wound closure of 100% at 72 h. The results reveal that the PVA/CHN/STP/ß-CD formula is promising for medical applications, especially in wound healing, compared with the silver sheet.

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“…Studies demonstrated that baicalin (Bai) regulated immune-mediated chronic inflammatory signaling by targeting PPAR-γ . In addition, Bai inhibited PDGF-BB-induced HSC activation and ameliorated LPS-induced HSCs migration in vitro . − Thus, Bai can be selected as an effective therapeutic agent against HSCs. Despite its pharmacological potential, the poor solubility of Bai compromises its in vivo bioavailability, necessitating an efficient delivery system to enhance its therapeutic efficacy.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil-Based Bionic Delivery System Breaks Through the Capillary Barrier of Liver Sinusoidal Endothelial Cells and Inhibits the Activation of Hepatic Stellate Cells

Sun,

Du,

Cao

et al. 2024

Mol. Pharmaceutics

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The capillarization of hepatic sinusoids resulting from the activation of hepatic stellate cells poses a significant challenge, impeding the effective delivery of therapeutic agents to the Disse space for liver fibrosis treatment. Therefore, overcoming these barriers and achieving efficient drug delivery to activated hepatic stellate cells (aHSCs) are pressing challenge. In this study, we developed a synergistic sequential drug delivery approach utilizing neutrophil membrane hybrid liposome@atorvastatin/amlisentan (NCM@AtAm) and vitamin A-neutrophil membrane hybrid liposome @ albumin (VNCM@Bai) nanoparticles (NPs) to breach the capillary barrier for targeted HSC cell delivery. Initially, NCM@AtAm NPs were successfully directed to the site of hepatic fibrosis through neutrophil-mediated inflammatory targeting, resulting in the normalization of liver sinusoidal endothelial cells (LSECs) and restoration of fenestrations under the combined influence of At and Am. Elevated tissue levels of the p-Akt protein and endothelial nitric oxide synthase (eNOS) indicated the normalization of LSECs following treatment with At and Am. Subsequently, VNCM@Bai NPs traversed the restored LSEC fenestrations to access the Disse space, facilitating the delivery of Bai into aHSCs under vitamin A guidance. Lastly, both in vitro and in vivo results demonstrated the efficacy of Bai in inhibiting HSC cell activation by modulating the PPAR γ/TGF-β1 and STAT1/ Smad7 signaling pathways, thereby effectively treating liver fibrosis. Overall, our designed synergistic sequential delivery system effectively overcomes the barrier imposed by LSECs, offering a promising therapeutic strategy for liver fibrosis treatment in clinical settings.

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Baicalin lipid nanocapsules for treatment of glioma: characterization, mechanistic cytotoxicity, and pharmacokinetic evaluation

Cited by 10 publications

References 67 publications

Multiple roles of baicalin and baicalein in the regulation of colorectal cancer

Multiple roles of baicalin and baicalein in the regulation of colorectal cancer

Synthesis of Cross-Linked and Sterilized Water-Soluble Electrospun Nanofiber Biomatrix of Streptomycin-Imbedded PVA/CHN/β-CD for Wound Healing

Neutrophil-Based Bionic Delivery System Breaks Through the Capillary Barrier of Liver Sinusoidal Endothelial Cells and Inhibits the Activation of Hepatic Stellate Cells

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