Baicalein inhibits lipid accumulation by regulating early adipogenesis and m-TOR signaling

Seo, Mi Sook; Choi, Hyeon‐Son; Jeon, Hui‐Jeon; Woo, Mi-Seon; Lee, Boo-Yong

doi:10.1016/j.fct.2014.02.009

Cited by 42 publications

(34 citation statements)

References 41 publications

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“…The protocol consisted of a 15-day exposure to the compound on a high-fat diet background, starting at the first feeding period. For example, curcumin [50–53], indole-3-carbinol [54], baicalein [55], dieckol [56], ellagic acid [52], kaempferol [51], quercetin [56], seapolynol [57] and silibinin [58], have all been reported to inhibit lipid accumulation in these early, post-embryonic developmental stages, when the adipocyte lineage is just starting to be established [20,27]. In our work, we used the ZOT protocol at later larval developmental stages, when the animals had a well-established WAT [30].…”

Section: Discussionmentioning

confidence: 99%

Caffeic acid and hydroxytyrosol have anti-obesogenic properties in zebrafish and rainbow trout models

et al. 2017

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Some natural products, known sources of bioactive compounds with a wide range of properties, may have therapeutic values in human health and diseases, as well as agronomic applications. The effect of three compounds of plant origin with well-known dietary antioxidant properties, astaxanthin (ATX), caffeic acid (CA) and hydroxytyrosol (HT), on zebrafish (Danio rerio) larval adiposity and rainbow trout (Onchorynchus mykiss) adipocytes was assessed. The zebrafish obesogenic test (ZOT) demonstrated the anti-obesogenic activity of CA and HT. These compounds were able to counteract the obesogenic effect produced by the peroxisome proliferator-activated receptor gamma (PPARγ) agonist, rosiglitazone (RGZ). CA and HT suppressed RGZ-increased PPARγ protein expression and lipid accumulation in primary-cultured rainbow trout adipocytes. HT also significantly reduced plasma triacylglycerol concentrations, as well as mRNA levels of the fasn adipogenic gene in the adipose tissue of HT-injected rainbow trout. In conclusion, in vitro and in vivo approaches demonstrated the anti-obesogenic potential of CA and HT on teleost fish models that may be relevant for studying their molecular mode of action. Further studies are required to evaluate the effect of these bioactive components as food supplements for modulating adiposity in farmed fish.

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Section: Discussionmentioning

confidence: 99%

Caffeic acid and hydroxytyrosol have anti-obesogenic properties in zebrafish and rainbow trout models

et al. 2017

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“…Adipocyte differentiation is initiated by differentiation inducers, such as insulin, 3-isobutyl-1-methylxanthine (IBMX), and dexamethasone (DEX) and early adipogenic transcription factors, such a CCAAT/enhancer-binding protein-β (C/EBPβ) are expressed [8]. These early adipogenic factors induce adipogenic key factors such as CCAAT/enhancer-binding protein-α (C/EBPα) and peroxisome proliferator-activated receptor-γ (PPARγ) [9]. Expression of C/EBPα and PPARγ activates lipid synthetic proteins, including fatty acid binding protein4 (FABP4) and lipin1, which play major roles in fatty acid transfer and triglyceride synthesis [10].…”

Section: Introductionmentioning

confidence: 99%

The inhibitory effects of quercetin on obesity and obesity-induced inflammation by regulation of MAPK signaling

Seo

Lee

Hwang

et al. 2015

The Journal of Nutritional Biochemistry

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162

118

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“…BCL has broad anti-tumor activity against breast, cervical and gastric cancers (Wang et al, 2014;Peng et al, 2015;Yan et al, 2015). The shortcomings of BCL which lead to poor clinical effect in vivo compared with its powerful efficacy in vitro, including extensive first-pass metabolism, low bioavailability, short half-life (10 min), poor water solubility and oxidized easily (Fong et al, 2012;Seo et al, 2014;Liu et al, 2015). DOX is an anthracycline antibiotic.…”

Section: Introductionmentioning

confidence: 99%

Co-delivery of baicalein and doxorubicin by hyaluronic acid decorated nanostructured lipid carriers for breast cancer therapy

Liu

et al. 2015

Drug Delivery

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Purpose: Combination anticancer therapy is promising to generate synergistic anticancer effects, to maximize the treatment effect and to overcome multi-drug resistance. Nanostructured lipid carriers (NLCs), composed of solid and liquid lipids, and surfactants are potentially good colloidal drug carriers. The aim of this study is to construct a hyaluronic acid (HA) decorated NLCs as nanocarriers for co-delivery baicalein (BCL) and doxorubicin (DOX). Methods: BCL-and DOX-loaded NLCs (BCL/DOX-NLCs) were prepared. HA ligands were used for the decoration of BCL/DOX-NLCs to form HA decorated BCL/DOX-NLCs (HA-BCL/DOX-NLCs). The in vitro cytotoxicity studies of different formulations were evaluated on DOX drug-resistant MCF-7 breast cancer cell line (MCF-7/ADR cells). In vivo anti-tumor effects were observed on the murine bearing MCF-7/ADR cells model. Results: HA-BCL/DOX-NLCs showed highest cytotoxicity and synergistic effect of two drugs in tumor cells in vitro. The in vivo study revealed the greatest anti-tumor activity than all the other formulations in the murine breast cancer model. Conclusions: HA decorated NLCs could be used as a novel carrier to co-delivery BCL and DOX for breast cancer therapy. HA-BCL/DOX-NLCs could be a promising targeted and combinational therapy nanomedicine.

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Baicalein inhibits lipid accumulation by regulating early adipogenesis and m-TOR signaling

Cited by 42 publications

References 41 publications

Caffeic acid and hydroxytyrosol have anti-obesogenic properties in zebrafish and rainbow trout models

Caffeic acid and hydroxytyrosol have anti-obesogenic properties in zebrafish and rainbow trout models

The inhibitory effects of quercetin on obesity and obesity-induced inflammation by regulation of MAPK signaling

Co-delivery of baicalein and doxorubicin by hyaluronic acid decorated nanostructured lipid carriers for breast cancer therapy

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