Bactibilia in women affected with diseases of the biliary tract and pancreas. A STROBE guidelines-adherent cross-sectional study in Southern Italy

Serra, Nicola; Carlo, Paola Di; Gulotta, Gaspare; Arpa, Francesco d'; Giammanco, Anna; Colomba, Claudia; Melfa, Giuseppina; Fasciana, Teresa; Sergi, Consolato

doi:10.1099/jmm.0.000787

Cited by 27 publications

(28 citation statements)

References 56 publications

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“…Blood was collected according to the microbiological recommendations for the diagnosis of IE and sent to the microbiology laboratory of the Department of Sciences for Health Promotion and Mother-Child Care, where a BD Phoenix™ system (BD Diagnostic Systems, Sparks, MD) determined species identification as previously reported [1,[20][21]. More than two separate blood cultures positive for coagulase-negative Staphylococci and other organisms that do not cause endocarditis were taken into account to define the microorganism responsible of IE according to the major criteria for the diagnosis of IE (Duke criteria) [2].…”

Section: Methodsmentioning

confidence: 99%

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Infective Endocarditis: Preliminary Results of a Cohort Study in the Southern Italian Population

Serra¹,

Colomba²,

Carlo³

et al. 2020

Cureus

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Background Infective endocarditis (IE) is an uncommon disease with an involved interplay of clinical and surgical team management. We aimed to define diagnosis parameters and delineate in-hospital management in patients with IE admitted in a tertiary hospital of Southern Italian. Materials and methods Fifty-six consecutive patients (42 males, 14 females; age range: 34-85 years) admitted for IE in the Infectious Diseases, Cardiac Surgery, and Cardiology units, between January 2011 and August 2017, were enrolled. Demographic data, mortality, comorbidities, specimen type, microscopy results, special histological staining performed, and antimicrobial therapy were collected and analyzed. Any comments at the multidisciplinary team meetings were recorded in minutes of and approved. Results We found 83.9% of patients with positive blood cultures. The four most common bacteria were methicillin-resistant Staphylococcus aureus (MRSA: 21.3%), methicillin-sensitive Staphylococcus aureus (MSSA: 17%), Streptococci (14.9%), and Enterococci (14.9%). Both in the univariate and multivariate analysis, we observed a significant positive correlation between surgery and complications. Particularly in the univariate analysis only, surgery was positively correlated to males and C-reactive protein (CPR) at baseline. Also, considering the most common bacteria, it resulted in a positive correlation between surgery and MRSA and Streptococci spp. and between complications and MSSA. Finally, the male gender was positively correlated to MSSA and heart complications, major arterial embolism, septic pulmonary emboli, splenic infarction, and cerebral embolism. Conclusions A blood culture test remains a critical factor for the diagnosis of IE and the antibiotic treatment 1 2 2,

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Section: Methodsmentioning

confidence: 99%

“…The identification of multidrug-resistant (MDR) gram-negative bacilli and Candida spp. were performed as previously reported [20][21]. Serological tests for pathogens that are epidemiologically relevant in our geographic area (i.e., Brucella spp.)…”

Section: Methodsmentioning

confidence: 99%

Infective Endocarditis: Preliminary Results of a Cohort Study in the Southern Italian Population

Serra¹,

Colomba²,

Carlo³

et al. 2020

Cureus

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“…are strongly and negatively associated with PHC. 356 Notably, patients with intraductal papillary mucinous neoplasms with high-grade dysplasia are characterized by high levels of IL-1β and intracystic bacteria that exhibit cooccurrence with abundant oral bacterial taxa, including F. nucleatum and Granulicatella adiacens, indicating the role of oral bacteria in cystic precursors to pancreatic cancer. 357 Indeed, as has been reported previously, unsatisfactory oral health conditions, pathogenic oral microbiomes (such as Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans), periodontitis, and tooth dislocation are correlated with a higher risk of pancreatic cancer.…”

Section: Zhang Et Almentioning

confidence: 99%

Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome

Zhang

Tang

Chen

et al. 2019

Sig Transduct Target Ther

184

151

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The trillions of microorganisms in the gut microbiome have attracted much attention recently owing to their sophisticated and widespread impacts on numerous aspects of host pathophysiology. Remarkable progress in large-scale sequencing and mass spectrometry has increased our understanding of the influence of the microbiome and/or its metabolites on the onset and progression of extraintestinal cancers and the efficacy of cancer immunotherapy. Given the plasticity in microbial composition and function, microbial-based therapeutic interventions, including dietary modulation, prebiotics, and probiotics, as well as fecal microbial transplantation, potentially permit the development of novel strategies for cancer therapy to improve clinical outcomes. Herein, we summarize the latest evidence on the involvement of the gut microbiome in host immunity and metabolism, the effects of the microbiome on extraintestinal cancers and the immune response, and strategies to modulate the gut microbiome, and we discuss ongoing studies and future areas of research that deserve focused research efforts.

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“…The human intestinal microbes comprise numerous micro-organisms that can influence the host immunity and cancer conditions because gut microbes and the immune system are mutually affected via metabolic crosstalk. A researcher surprisingly discovered that PC is strongly correlated with Gram-negative gamma-proteobacteria-(GP-) Escherichia coli (E. coli) [3]. Moreover, Geller et al have demonstrated that GP can induce chemoresistance of Gemcitabine (Gem, the first-line drug of chemotherapy for PC patients) in PC patients by metabolizing Gem into an ineffective form, providing that gut bacteria contribute to worse outcomes of PC patients by making chemotherapeutic drug invalid [4].…”

Section: Introductionmentioning

confidence: 99%

“…Venn diagram DEGs were selected with P < 0:01 and fold change > 2 among the mRNA expression profiling sets GSE27890, GSE46234, and GSE107610. A total of 84 overlapping genes were obtained 3. BioMed Research International concluded that the gut bacteria can modulate tumor bacteria composition to regulate the progression of PC and the survival rate of PC patients.…”

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confidence: 99%

Novel Discoveries Targeting Pathogenic Gut Microbes and New Therapies in Pancreatic Cancer: Does Pathogenic E. coli Infection Cause Pancreatic Cancer Progression Modulated by TUBB/Rho/ROCK Signaling Pathway? A Bioinformatic Analysis

Luo

Cao

Qiu

et al. 2020

BioMed Research International

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Pancreatic cancer (PC) is a pernicious cancer of the digestive system which remains a high degree of malignancy. Increasing studies demonstrated that regulating the gut microbiome may become a brand new strategy to improve the therapeutic outcomes of PC. This study is aimed at obtaining the pathway in the microbial tumorigenesis of PC. Microarray datasets GSE27890, GSE46234, and GSE17610 were downloaded from the GEO (Gene Expression Omnibus) database. Differential analysis was performed for every single gene chip using the R software package (“Limma” package), and functional enrichment analyses were carried out by DAVID (Database for Annotation, Visualization and Integrated Discovery). The PPI (protein-protein interaction) network was constructed with the Search Tool for the Retrieval of Interacting Genes (STRING). The survival analysis was performed by GEPIA and USCS. A total of 84 differentially expressed genes (DEGs) were identified, and 3 of them were extracted (TUBB, TUBA4A, and TLR5). Biological process analysis revealed that these 3 genes were mainly enriched in pathogenic Escherichia coli (E. coli) infection. Survival analysis and pathway analysis revealed that TUBB (tubulin, beta class I) may be associated with the pathogenic E. coli infection, which may be involved in the carcinogenesis and progression of PC by activating the TUBB/Rho/ROCK signaling pathway. Elevated evidence indicated that a specific gut microbe could affect the progression of PC by suppressing immune response. However, little attention has been paid to the relationship and crosstalk between TUBB/Rho/ROCK signaling, microbes, and PC. This article is aimed at deducing that gut and tumor microbes are related to the development of PC by stimulating TUBB/Rho/ROCK signaling, while ablation of microbes by antibiotics cotreated with inhibitors of TUBB/Rho/ROCK signaling were identified as a novel target for PC therapy.

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Bactibilia in women affected with diseases of the biliary tract and pancreas. A STROBE guidelines-adherent cross-sectional study in Southern Italy

Cited by 27 publications

References 56 publications

Infective Endocarditis: Preliminary Results of a Cohort Study in the Southern Italian Population

Infective Endocarditis: Preliminary Results of a Cohort Study in the Southern Italian Population

Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome

Novel Discoveries Targeting Pathogenic Gut Microbes and New Therapies in Pancreatic Cancer: Does Pathogenic E. coli Infection Cause Pancreatic Cancer Progression Modulated by TUBB/Rho/ROCK Signaling Pathway? A Bioinformatic Analysis

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