Bacteriophage: Potential Role in Food Safety

Huff, W. E.; Huff, G. R.; Rath, N. C.; Balog, J. M.; Donoghue, Annie

doi:10.1002/9780470752579.ch27

Cited by 4 publications

(5 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They have been used to prevent and treat various bacterial diseases in humans and animals (Huff et al ., 2003; Miller et al ., 2010). A significant amount of research was also done on their use in control of food-borne pathogens on agricultural and poultry products (Goode et al ., 2003; Huff et al ., 2004). Very few studies demonstrated the effects of supplementing diets with bacteriophages on growth performance.…”

Section: Bacteriophagesmentioning

confidence: 99%

Alternatives to antibiotics for maximizing growth performance and feed efficiency in poultry: a review

Gadde

Kim

et al. 2017

Anim. Health. Res. Rev.

552

423

View full text Add to dashboard Cite

With the increase in regulations regarding the use of antibiotic growth promoters and the rise in consumer demand for poultry products from 'Raised Without Antibiotics' or 'No Antibiotics Ever' flocks, the quest for alternative products or approaches has intensified in recent years. A great deal of research has focused on the development of antibiotic alternatives to maintain or improve poultry health and performance. This review describes the potential for the various alternatives available to increase animal productivity and help poultry perform to their genetic potential under existing commercial conditions. The classes of alternatives described include probiotics, prebiotics, synbiotics, organic acids, enzymes, phytogenics, antimicrobial peptides, hyperimmune egg antibodies, bacteriophages, clay, and metals. A brief description of the mechanism of action, efficacy, and advantages and disadvantages of their uses are also presented. Though the beneficial effects of many of the alternatives developed have been well demonstrated, the general consensus is that these products lack consistency and the results vary greatly from farm to farm. Furthermore, their mode of action needs to be better defined. Optimal combinations of various alternatives coupled with good management and husbandry practices will be the key to maximize performance and maintain animal productivity, while we move forward with the ultimate goal of reducing antibiotic use in the animal industry.

show abstract

Section: Bacteriophagesmentioning

confidence: 99%

Alternatives to antibiotics for maximizing growth performance and feed efficiency in poultry: a review

Gadde

Kim

et al. 2017

Anim. Health. Res. Rev.

552

423

View full text Add to dashboard Cite

show abstract

“…However, administering the same bacteriophages through drinking water was not effective in preventing the onset of the disease. Additionally, it was shown that bacteriophage aerosol therapy, followed by an E. coli challenge the following day, 2 days later, or 3 days later, reduced death linked to respiratory illness (Huff et al, 2002). Thus, that study demonstrated the respiratory system's capacity for bacteriophage prevention.…”

Section: Escherichia Colimentioning

confidence: 64%

“…This study also demonstrated that when host bacteria are present in both the blood and the brain, bacteriophages can cross the bloodbrain barrier and multiply. Bacteriophages were used by Huff et al (2003) to treat chicken airsacculitis caused by E. coli. By injecting bacteriophage along with the bacterial challenge inoculum into the thoracic air sac, significant effectiveness was reached.…”

Section: Escherichia Colimentioning

confidence: 99%

An overview of the use of bacteriophages in the poultry industry: Successes, challenges, and possibilities for overcoming breakdowns

et al. 2023

View full text Add to dashboard Cite

The primary contaminants in poultry are Salmonella enterica, Campylobacter jejuni, Escherichia coli, and Staphylococcus aureus. Their pathogenicity together with the widespread of these bacteria, contributes to many economic losses and poses a threat to public health. With the increasing prevalence of bacterial pathogens being resistant to most conventional antibiotics, scientists have rekindled interest in using bacteriophages as antimicrobial agents. Bacteriophage treatments have also been investigated as an alternative to antibiotics in the poultry industry. Bacteriophages’ high specificity may allow them only to target a specific bacterial pathogen in the infected animal. However, a tailor-made sophisticated cocktail of different bacteriophages could broaden their antibacterial activity in typical situations with multiple clinical strains infections. Bacteriophages may not only be used in terms of reducing bacterial contamination in animals but also, under industrial conditions, they can be used as safe disinfectants to reduce contamination on food-contact surfaces or poultry carcasses. Nevertheless, bacteriophage therapies have not been developed sufficiently for widespread use. Problems with resistance, safety, specificity, and long-term stability must be addressed in particular. This review highlights the benefits, challenges, and current limitations of bacteriophage applications in the poultry industry.

show abstract

“…This, however, can be a limitation because as Joerger (2003) points out, no single phage is capable of attacking all Salmonella serovars. Another key for using bacteriophage as a biological feed amendment is assuring an effective oral administration of the phage and survival of the phage until it arrives to sites in the intestine colonized by the respective pathogen (Huff et al, 2004). However, this may be less of a concern since viable phage can be isolated from intestinal tracts as well as from feed (Macioroski et al, 2001b;Joerger, 2003).…”

Section: Feed Additives To Eliminate Colonized Salmonella Sppmentioning

confidence: 99%

“…This suggests that phage survival in these potentially hostile environments is possible. Other limitations include the potential for gene transfer among phage infected bacteria, development of bacterial resistance, and potential governmental regulation issues (Huff et al, 2004).…”

Section: Feed Additives To Eliminate Colonized Salmonella Sppmentioning

confidence: 99%