Bacteriophage: A New Hope for the Control of Antibiotic-Resistant Bacteria

Sagar, Sadhana; Kaistha, Shilpa Deshpande; Das, Amar Jyoti; Kumar, Rajesh

doi:10.1007/978-981-13-9879-7_11

Cited by 2 publications

(2 citation statements)

References 47 publications

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“…Control of drug-resistant bacteria by phages has been in practice since the initial phase of the 19th century. 52 Nonetheless, one limitation of phage therapy is that bacteria may develop resistance mechanisms to them. 12 As a result, phages may be rendered ineffective in eliminating phage-resistant cells.…”

Section: Resultsmentioning

confidence: 99%

Combined Effect of Isolated Bacteriophage and Neem Extract on Isolated Multiple Drug-Resistant Pathogenic Escherichia coli E1 From Well Water

Sagar,

Rani,

Pushpa Sadanandan

2023

Environ�Health�Insights

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Multiple drug-resistant Escherichia coli ( E. coli) is a serious cause of concern, and they can be observed in hospital settings, natural environment, and animals. Dissemination of multiple drug-resistant (MDR) E. coli can pose a high risk to public health. Moreover, they are hard to control with commercial antibiotics, since they have acquired resistance against most of them. Therefore, to control multiple drug-resistant bacteria, alternative strategies have been adopted such as phage therapy, herbal remedies, nanoparticles etc. In the current study, the combined application of neem leaf extract and bacteriophage is used to control an isolated multiple drug-resistant E. coli E1. We have applied 0.1 mg/ml concentration of neem extract in combination with an isolated phage vB_EcoM_C2 of 1011 titer and found that the combinatorial treatment approach significantly controls the growth of E. coli E1 as compared to a single non-combinatorial treatment. In this study, every E. coli cell is targeted by 2 antimicrobials (phage and neem extract) at the same time, which is more effective as compared to the sole treatment. Implementation of the neem extract with phage opens a new alternative approach to the chemotherapeutics for the control of multiple drug-resistant bacterial pathogens. This approach may be effective, economical, and eco-friendly to combat MDR.

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Section: Resultsmentioning

confidence: 99%

Combined Effect of Isolated Bacteriophage and Neem Extract on Isolated Multiple Drug-Resistant Pathogenic Escherichia coli E1 From Well Water

Sagar,

Rani,

Pushpa Sadanandan

2023

Environ�Health�Insights

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“…In recent times, the rise of bacterial resistance to commonly used antibiotics has significantly impacted the effective treatment of bacterial infections. The United Nations General Assembly has highlighted antibiotic resistance as a critical global peril that humanity confronts [147]. Consequently, exploring alternative strategies to combat bacterial growth has become imperative, with nanoparticles emerging as a promising solution, due to their strong antibacterial properties.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Magnesium Oxide (MgO) Nanoparticles: Synthetic Strategies and Biomedical Applications

Gatou,

Skylla,

Dourou

et al. 2024

Crystals

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In recent times, there has been considerable interest among researchers in magnesium oxide (MgO) nanoparticles, due to their excellent biocompatibility, stability, and diverse biomedical uses, such as antimicrobial, antioxidant, anticancer, and antidiabetic properties, as well as tissue engineering, bioimaging, and drug delivery applications. Consequently, the escalating utilization of magnesium oxide nanoparticles in medical contexts necessitates the in-depth exploration of these nanoparticles. Notably, existing literature lacks a comprehensive review of magnesium oxide nanoparticles’ synthesis methods, detailed biomedical applications with mechanisms, and toxicity assessments. Thus, this review aims to bridge this gap by furnishing a comprehensive insight into various synthetic approaches for the development of MgO nanoparticles. Additionally, it elucidates their noteworthy biomedical applications as well as their potential mechanisms of action, alongside summarizing their toxicity profiles. This article also highlights challenges and future prospects for further exploring MgO nanoparticles in the biomedical field. Existing literature indicates that synthesized magnesium oxide nanoparticles demonstrate substantial biocompatibility and display significant antibacterial, antifungal, anticancer, and antioxidant properties. Consequently, this review intends to enhance readers’ comprehension regarding recent advancements in synthesizing MgO nanoparticles through diverse approaches and their promising applications in biomedicine.

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Bacteriophage: A New Hope for the Control of Antibiotic-Resistant Bacteria

Cited by 2 publications

References 47 publications

Combined Effect of Isolated Bacteriophage and Neem Extract on Isolated Multiple Drug-Resistant Pathogenic Escherichia coli E1 From Well Water

Combined Effect of Isolated Bacteriophage and Neem Extract on Isolated Multiple Drug-Resistant Pathogenic Escherichia coli E1 From Well Water

Magnesium Oxide (MgO) Nanoparticles: Synthetic Strategies and Biomedical Applications

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