Bacteriological profile of critically ill patients with chronic obstructive pulmonary disease in respiratory intensive care unit in Assuit University Hospital

Ghanem, Maha; Makhlouf, Hoda A; Hasan, Ali A.; Rashed, Heba; Khalifa, Hadeer S.

doi:10.4103/ejb.ejb_83_18

Cited by 7 publications

(8 citation statements)

References 12 publications

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“…K. pneumoniae 25.4% was the most frequent bacterial isolate followed by Pseudomonas spp 17.6%, E. coli 15.5% and S. aureus 14.8%. This finding is similar to the study conducted in Assuit, Egypt [ 19 ], in which K. pneumoniae 58% was the most frequent isolate followed by P. aeruginosa 28%. This finding also agrees with Janakpur, Nepal 27.0% [ 20 ], Zagazig, Egypt, 10.4% [ 15 ] and 31.5% South India [ 16 ], in which K. pneumoniae was the commonest detected of LRTI.…”

Section: Discussionsupporting

confidence: 90%

Bacterial profile and drug susceptibility among adult patients with community acquired lower respiratory tract infection at tertiary hospital, Southern Ethiopia

2021

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Background Lower respiratory tract infection is a global problem accounting over 50 million deaths annually. Here, we determined the bacterial profile and antimicrobial susceptibility pattern of lower respiratory tract infections among adult patients attending at Tertiary Hospital, Southern Ethiopia. Methods A cross sectional study was conducted among adult patients with lower respiratory infection at the medical outpatient department of the Hospital. A sputum sample was collected and processed for bacterial culture and antimicrobial susceptibility test. Semi structured questionnaires were used to collect data. SPSS version 22 software was used for statistical analysis and a p value of < 0.05 was considered as statistically significant. Results Out of 406 sputum samples of participants 136(33.5%) were culture positive for 142 bacterial isolates. Klebsiella pneumoniae 36(25.4%) was the predominant isolate followed by Pseudomonas species 25(17.6%). Gram-negative bacteria were sensitive to cefepime (86.0%) and ciprofloxacin (77.8%) antibiotics while gram-positive (76.5%) to clindamycin. Conclusion Community acquired lower respiratory tract Infection was highly prevalent in the study area and the isolates showed resistant to common antibiotics such as ampicillin, augmentin, ceftazidime and tetracycline. Therefore, culture and susceptibility test is vital for appropriate management of lower respiratory tract infection in the study area.

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Section: Discussionsupporting

confidence: 90%

Bacterial profile and drug susceptibility among adult patients with community acquired lower respiratory tract infection at tertiary hospital, Southern Ethiopia

2021

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“…When we come to specific bacterial isolates, in this study, Pseudomonas aeruginosa and K. pneumoniae were the predominant bacterial isolates as reported in similar studies from Egypt [ 16 ], Tunisia [ 30 ], and India [ 18 ]. On the other hand, to a study report from India [ 31 ], S. pneumoniae and H. influenza or methicillin-resistant Staphylococcus aureus (MRSA) were frequently isolated organisms.…”

Section: Discussionmentioning

confidence: 64%

“…While a lower rate was reported in other studies from India 42.9% [ 25 ] and 47.22% [ 4 ] than the current study finding. On the other hand, a higher rate was reported from Egypt 94% [ 16 ]. Gram-negative bacterial isolate was predominating, 78.1% in this study.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, inpatient mortality of AECOPD patients was 20.5% with 87.5% mortality due to MDR P. aeruginosa and Acinetobacter species-induced infections ( Table 2 ). In different studies reported from Egypt [ 16 ] and Serbia [ 26 ] mortality among COPD exacerbation patients was (50%) and (6.2%) with 100% P. aeruginosa induced infection, respectively. In this study, mortality was lower than reported mortality from Egypt and higher than mortality reported from Serbia.…”

Section: Discussionmentioning

confidence: 99%

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Bacterial Isolates and Antibacterial Resistance Patterns in a Patient with Acute Exacerbation of Chronic Obstructive Pulmonary Disease in a Tertiary Teaching Hospital, Southwest Ethiopia

Mussema

Beyene

Gashaw

2022

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Introduction. Chronic obstructive pulmonary disease (COPD) is a major cause of chronic morbidity and mortality worldwide. The natural course of COPD is characterized by acute exacerbation. Infectious agents, particularly bacteria, cause exacerbation of COPD in the majority. This study aimed to determine the bacteriology and antibiotic resistance patterns among patients with acute exacerbations of COPD (AECOPD) at Jimma Medical Center. Methods. A cross-sectional study was conducted from March to October 2019. Demographic, clinical, and sputa samples were collected from 39 study participants, who were diagnosed with AECOPD. Bacterial pathogens were identified using standard bacteriological techniques, and anti-microbial susceptibility testing was done by Kirby Bauer’s disk diffusion method. Extended-spectrum β-lactamase (ESβL) and carbapenemase production were confirmed by MASTTM D68C and MASTTM D73C combination disc sets, respectively. Chi-square and odds ratios were calculated. Results. Overall, 69.2% (27/39) of sputum samples were confirmed to be culture-positive. A total of 32 bacterial isolates with 78.1% (25/32) Gram-negative and 21.9% (7/32) Gram-positive bacteria were identified. The predominant bacterial isolates were Pseudomonas aeruginosa 21.9% (7/32), Klebsiella pneumoniae 18.75% (6/32), and Staphylococcus aureus 15.62% (7/32). Overall, 30 (93.8%) of the isolates were multidrug-resistant (MDR). About 48% (12/25) and 8 (32%)of gram negative bacterial isolates were ESBL betalatemase and OXA-48 carbapenemase producers, respectively. Having two or more exacerbation experiences in the previous year were found to be important determinants of the sputum culture positivity. Conclusions. High rates of MDR, ESBL, and carbapenemase producer bacteria were isolated from patients with AECOPD. Empiric antibiotic therapy should consider the prevalence of antibiotic-resistant pathogens and the factor that may increase the occurrence of MDR bacterial pathogens.

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“…In India, Pseudomonas aeruginosa was usually found to be the second most common bacteria causing AECOPD after Klebsiella pneumoniae but in some studies, it is the most predominant [ 17 , 18 ]. Globally, Acinetobacter baumannii and Escherichia coli are, in general, not commonly associated with AECOPD [ 19 , 20 ]. In India, Acinetobacter baumannii was prominent in one prospective study among ICU patients [ 15 ] with AECOPD, compared to other Indian studies [ 16 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

Trends in the Bacterial Prevalence and Antibiotic Resistance Patterns in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Hospitalized Patients in South India

et al. 2022

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Exacerbation due to antimicrobial-drug-resistant bacteria among chronic obstructive pulmonary disease (AECOPD) patients contributes to mortality and morbidity. We examined the prevalence of the bacterial organisms and trends in drug resistance in AECOPD. In this retrospective study, between January 2016 to December 2020, among 3027 AECOPD patients, 432 (14.3%) had bacteria isolated. The regression and generalized estimating equations (GEE) were used for trends in the resistance patterns over five years, adjusting for age, gender, and comorbidities. Klebsiella pneumoniae (32.4%), Pseudomonas aeruginosa (17.8%), Acinetobacter baumannii (14.4%), Escherichia coli (10.4%), and Staphylococcus aureus (2.5%) were common. We observed high levels of drug resistance in AECOPD patients admitted to ICU (87.8%) and non-ICU (86.5%). A Cox proportional hazard analysis, observed infection with Acinetobacter baumannii and female sex as independent predictors of mortality. Acinetobacter baumannii had 2.64 (95% confidence interval (CI): 1.08–6.43) higher odds of death, compared to Klebsiella pneumoniae. Females had 2.89 (95% CI: 1.47–5.70) higher odds of death, compared to males. A high proportion of bacterial AECOPD was due to drug-resistant bacteria. An increasing trend in drug resistance was observed among females.

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Bacteriological profile of critically ill patients with chronic obstructive pulmonary disease in respiratory intensive care unit in Assuit University Hospital

Cited by 7 publications

References 12 publications

Bacterial profile and drug susceptibility among adult patients with community acquired lower respiratory tract infection at tertiary hospital, Southern Ethiopia

Bacterial profile and drug susceptibility among adult patients with community acquired lower respiratory tract infection at tertiary hospital, Southern Ethiopia

Bacterial Isolates and Antibacterial Resistance Patterns in a Patient with Acute Exacerbation of Chronic Obstructive Pulmonary Disease in a Tertiary Teaching Hospital, Southwest Ethiopia

Trends in the Bacterial Prevalence and Antibiotic Resistance Patterns in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Hospitalized Patients in South India

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