Bacteriological profile and antimicrobial sensitivity pattern of blood culture isolates among septicemia-suspected children at Tikur Anbessa Specialized Hospital and Yekatit 12 Hospital, Addis Ababa, Ethiopia

Negussie, Adugna; Mulugeta, Gebru; Bedru, Ahmed; Ali, Ibrahim; Shimeles, Damte; Lema, Tsehaynesh; Aseffa, Abraham

doi:10.1186/cc12911

Cited by 48 publications

(84 citation statements)

References 21 publications

(42 reference statements)

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“…1 (2.6). These findings are close to results obtained by Tariq et al 12 , Om Prakash et al 11 and Aduga Negusie et al 13 In the present study gram negative organisms showed less sensitivity to Amoxicillin clavulanate and Amikacin. Sensitivity result being Klebsiella pneumoniae 22% and 33%, Acinetobacter spp.…”

Section: Discussionsupporting

confidence: 82%

Bacteriological Profile and Antibiotic Susceptibility Pattern of Neonatal Septicaemia

Singh¹,

Bankar²

2016

jemds

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Neonatal sepsis is one of the most common causes of neonatal mortality and morbidity, particularly in the developing countries. Appropriate clinical diagnosis and empirical treatment is crucial as pathogens causing sepsis and their antibiotic susceptibility pattern varies in different settings. The objective of this study was to determine the causative bacteria and pattern of susceptibility to antibiotics in NICU, which in turn may help in implementation of empirical therapy. MATERIALS AND METHODA total of 100 blood samples were screened for sepsis in newborns less than 28 days old in this prospective study. The blood cultures of suspected cases were detected by using BACTEC blood culture systems and antibiotic susceptibility testing was done by using Kirby-Bauer disk diffusion method. This prospective observational study was conducted in the Department of RESULTSIn this study out of 100 neonates 38 (38%) showed sepsis and 62 (62%) showed no sepsis. Most common organisms responsible for the sepsis were CONS followed by Klebsiella pneumonia and Acinetobacter sp. Gram negative organisms were 100% sensitive to Colistin, Imipenem and Meropenem while Gram positive organisms were 100% sensitive to Azithromycin, Linezolid and Vancomycin. CONCLUSIONThe diagnostic capabilities of blood culture systems have improved over the last decade with the advent of automated continuous blood culture monitoring systems. BACTEC is a sensitive method and lead to earlier detection of bacterial growth.

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Section: Discussionsupporting

confidence: 82%

Bacteriological Profile and Antibiotic Susceptibility Pattern of Neonatal Septicaemia

Singh¹,

Bankar²

2016

jemds

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“…The resistance to most preferred agents to S.auerus infection like methicillin and Vancomyicn have dangerously increased compared to previous similar studies [20–22, 25, 26]. About 96.8% of S.aureus was cloxacillin/methicillin resistant (MRSA) and 74.2%was vancomycin resistant (VRSA).…”

Section: Discussionmentioning

confidence: 96%

Antimicrobial resistance profile of Staphylococcus aureus isolates isolated from ear discharges of patients at University of Hawassa comprehensive specialized hospital

Deyno

Toma

Worku

et al. 2017

BMC Pharmacol Toxicol

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Background: Drug-resistant microorganism are a growing global danger. Strains of S. aureus have developed resistance to many commonly used antimicrobials due to indiscriminate use of antimicrobials, and treatment becoming a challenge. Studies assessing pattern and determinants of S. aureus resistance in ear infection in Ethiopia are very scarce. This study presents overview of pattern and determinants S. aureus resistance from samples of ear discharge in Ethiopia. Method: A prospective cross-sectional study was conducted on patients who visit ENT clinic of University of Hawassa comprehensive specialized hospital from February 1, 2016 to November 1, 2016. 117 specimens were collected with sterile applicator cotton swab from 117 patients with ear discharge visiting the clinic. Data was fed and then edited, cleared, entered and analyzed using SPSS version 20. Result: The prevalence of S.aureus infection was 28.2%. S. aureus isolates revealed up to 97.0% level of resistance pattern to the antimicrobials tested. In the determination of the susceptibility of S. aureus on nine selected antibiotics by disk diffusion technique, 97.0% of the isolates were resistant to cloxacilin and 74.2% showed resistance to vancomycin. The overall rate of MDR was 100%, all of the isolates were found to be resistant to more than two tested antimicrobials. Conclusion: S. aureus has gotten frighteningly resistant to many of common antimicrobials. Resistance rate to vancomyin is terrifyingly high. It urges us to take measures to delay resistance. Emergence of resistance highlights the value of prudent prescribing of antimicrobials and avoiding their irrational use. Further researches focusing on identifying dynamics promoting resistance, identifying high risk strains and molecular basis of resistance are required.

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“…Bakteriyemi ve sepsis, yüksek mortalite ve morbiditeyle seyreden, erken tanı konulup tedavi edildiğinde mortalite oranlarının önemli ölçüde azaldığı bir klinik tablodur (2) . Geniş spektrumlu antibiyotiklerin kullanıma girmesi, hasta popü-lasyonundaki değişiklikler, immunsupresyon, altta yatan hastalıklardaki artış, kateter ve intravenoz solüsyonların daha sık kullanılması gibi nedenlerle, son yıllarda mikroorganizmaların kandan izole edilme oranlarında artış olmuş-tur (8) .…”

Section: Discussionunclassified

“…Kan dolaşımı enfeksiyonları kendini sınırlayan enfeksiyonla yaşamı tehdit eden sepsis, çoklu organ yetmezliği, yaygın damar içi pıhtılaşma gibi çeşitli klinik tablolara neden olabilir. Bu yüzden hızlı ve agresif antimikrobiyal tedaviye gereksinim duyulmaktadır (2) . Bakteriyemi ve sepsis, yüksek morbidite ve mortalite oranları ile seyreden, erken tanı konulup tedavi edilmesi gereken klinik tablolardır (3) .…”

Section: Introductionunclassified

Kan Kültürlerinde İzole Edilerek Tanımlanan Mikroorganizmaların ve Antibiyotik Direnç Oranlarının Belirlenmesi

Er¹,

Aşık²,

Yoldaş³

et al. 2015

TMCD

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Bacteriological profile and antimicrobial sensitivity pattern of blood culture isolates among septicemia-suspected children at Tikur Anbessa Specialized Hospital and Yekatit 12 Hospital, Addis Ababa, Ethiopia

Cited by 48 publications

References 21 publications

Bacteriological Profile and Antibiotic Susceptibility Pattern of Neonatal Septicaemia

Bacteriological Profile and Antibiotic Susceptibility Pattern of Neonatal Septicaemia

Antimicrobial resistance profile of Staphylococcus aureus isolates isolated from ear discharges of patients at University of Hawassa comprehensive specialized hospital

Kan Kültürlerinde İzole Edilerek Tanımlanan Mikroorganizmaların ve Antibiyotik Direnç Oranlarının Belirlenmesi

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