Bacterial Quorum-Sensing Peptides as Immune Modulators Present in Systemic Circulation

Spiegeleer, Anton De; Descamps, Amélie; Govindarajan, Srinath; Coudenys, Julie; borght, Kevin Van der; Hirmz, Hannah; Noortgate, Nele Van Den; Elewaut, Dirk; Spiegeleer, Bart De; Wynendaele, Evelien

doi:10.3390/biom13020296

Cited by 5 publications

(2 citation statements)

References 37 publications

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“…This screen identified several peptides that induced a significant immune response, including hits from Staphylococcus aureus , Staphylococcus epidermidis , Bacillus cereus , Bacillus thuringiensis , and Enterococcus faecalis . This study also identified the Bacillus peptide pheromone PapR71 in human plasma, indicating that bacterial signaling peptides with immunomodulatory activity may be biologically relevant in the host context ( De Spiegeleer et al., 2023 ). The evaluation of bacterial peptides traditionally associated with quorum sensing for their ability to induce host immune responses therefore represents an interesting approach for identifying new ways by which bacteria modulate their host environment.…”

Section: Discussionmentioning

confidence: 83%

Streptococcal peptides and their roles in host-microbe interactions

Wahlenmayer,

Hammers

2023

Front. Cell. Infect. Microbiol.

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The genus Streptococcus encompasses many bacterial species that are associated with hosts, ranging from asymptomatic colonizers and commensals to pathogens with a significant global health burden. Streptococci produce numerous factors that enable them to occupy their host-associated niches, many of which alter their host environment to the benefit of the bacteria. The ability to manipulate host immune systems to either evade detection and clearance or induce a hyperinflammatory state influences whether bacteria are able to survive and persist in a given environment, while also influencing the propensity of the bacteria to cause disease. Several bacterial factors that contribute to this inter-species interaction have been identified. Recently, small peptides have become increasingly appreciated as factors that contribute to Streptococcal relationships with their hosts. Peptides are utilized by streptococci to modulate their host environment in several ways, including by directly interacting with host factors to disrupt immune system function and signaling to other bacteria to control the expression of genes that contribute to immune modulation. In this review, we discuss the many contributions of Streptococcal peptides in terms of their ability to contribute to pathogenesis and disruption of host immunity. This discussion will highlight the importance of continuing to elucidate the functions of these Streptococcal peptides and pursuing the identification of new peptides that contribute to modulation of host environments. Developing a greater understanding of how bacteria interact with their hosts has the potential to enable the development of techniques to inhibit these peptides as therapeutic approaches against Streptococcal infections.

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Section: Discussionmentioning

confidence: 83%

Streptococcal peptides and their roles in host-microbe interactions

Wahlenmayer,

Hammers

2023

Front. Cell. Infect. Microbiol.

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“…The even more interesting aspect that emerged from the explorative data is that for certain of these peptides, the inflammatory effect would be age-dependent. Moreover, for a biologically relevant microbiome-host immune system interaction, a role of primary importance would hypothetically refer to QSPs produced by skin bacteria such as staphylococcal species [176].…”

Section: Cutaneous Microbiome As a Specific Pattern Of Frailtymentioning

confidence: 99%

Immunosenescence and Skin: A State of Art of Its Etiopathogenetic Role and Crucial Watershed for Systemic Implications

Papa

Pomi

Borgia

et al. 2023

IJMS

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Immunosenescence is a complex multifactorial phenomenon consisting of wide-ranging remodeling of the immune system during the life span, resulting in an age-related qualitative–quantitative decline of immune cells and cytokines. A growing body of evidence in the international literature is highlighting the etiopathogenetic role of skin immunosenescence in the onset of various dermatologic conditions. Skin immunosenescence also serves as an interesting watershed for the onset of system-wide conditions in the context of allergic inflammation. Moreover, in recent years, an increasingly emerging and fascinating etiopathogenetic parallelism has been observed between some mechanisms of immunosenescence, both at cutaneous and systemic sites. This would help to explain the occurrence of apparently unconnected comorbidities. Throughout our review, we aim to shed light on emerging immunosenescent mechanisms shared between dermatologic disorders and other organ-specific diseases in the context of a more extensive discussion on the etiopathogenetic role of skin immunosenescence. A promising future perspective would be to focus on better understanding the mutual influence between skin and host immunity, as well as the influence of high inter-individual variability on immunosenescence/inflammaging. This can lead to a more comprehensive “immunobiographic” definition of each individual.

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