2001
DOI: 10.1007/978-1-4615-1267-7_30
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Abstract: Studies on protective inununity and biochemical characterization of bacterial capsular polysaccharides (PSs) have led to many significant contributions to understanding the mechanisms of infectious diseases, host defense, and development of effective vaccines. The discovery of a specific soluble substance produced by pneumococci as a carbohydrate, provided evidence regarding the specificity of PS antigens for antibody production. It was the first non-protein antigen found to induce antibody response in humans … Show more

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Cited by 32 publications
(15 citation statements)
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“…Streptococcal surface capsules are generally complex anionic polysaccharides that contribute importantly to virulence by virtue of their antiphagocytic properties (26). Streptococcal capsular polysaccharides are also frequently a principal target of protective immunity in natural infection and can represent effective vaccine antigens particularly when conjugated to protein carriers (23). Decreased buoyancy, decreased surface negative charge, and increased hydrophobicity as measured in our S. iniae ⌬PGM mutant are changes consistent with diminished expression of a polyanionic surface capsule.…”
Section: Discussionsupporting
confidence: 60%
“…Streptococcal surface capsules are generally complex anionic polysaccharides that contribute importantly to virulence by virtue of their antiphagocytic properties (26). Streptococcal capsular polysaccharides are also frequently a principal target of protective immunity in natural infection and can represent effective vaccine antigens particularly when conjugated to protein carriers (23). Decreased buoyancy, decreased surface negative charge, and increased hydrophobicity as measured in our S. iniae ⌬PGM mutant are changes consistent with diminished expression of a polyanionic surface capsule.…”
Section: Discussionsupporting
confidence: 60%
“…Strategies to circumvent these limiting factors are the coupling of the polysaccharide structure to a carrier targeting T-cell-dependent responses (T-cell memory) and the use of peptides mimicking immunodominant structures (103,140,142,143). Hot topics in EPS/CPS vaccine development are vaccination strategies against N. meningitidis, H. influenzae type b, and S. pneumoniae (144).…”
Section: Fig 5 Eps and Cps Biosynthesis Pathways (A)mentioning
confidence: 99%
“…They have been shown to be important for adherence to and invasion of host tissues (10,19), for resistance to host defense systems such as phagocytosis (1,2,8,12,24,30), and for induction of host inflammatory responses (14,25). Vaccine potential of surface polysaccharides has been shown for different bacteria, such as pneumococci (20), and antibodies against capsular carbohydrates have been shown to promote polymorphonuclear leukocyte (PMN)-mediated killing of E. faecalis and Enterococcus faecium and to protect mice against E. faecalis infection (16)(17)(18)24). These capsular carbohydrates of E. faecalis have been shown to be type specific, and the type-specific genes are present only in some populations of enterococci (16)(17)(18).…”
mentioning
confidence: 99%