Bacterial melanin in rat models of Parkinson′s disease: a potential neuroprotective strategy

Petrosyan, Tigran

doi:10.4103/1673-5374.152372

Cited by 6 publications

(6 citation statements)

References 7 publications

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“…Bacterial melanin produced in biotechnology Institute of Armenia is one of the options and possesses clinical and pharmaceutical perspectives. [25][26][27] The number of melanin-containing ointments and creams continues to grow, increasing the potential risk for adverse reactions. Different companies produce melanin using variety of biotechnological methodologies and risk for adverse reactions becomes more evident, varying between the formulas.…”

Section: Discussionmentioning

confidence: 99%

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Assessing the frequency of adverse reactions induced by melanin‐containing formulations used for the management of solar dermatitis

Petrosyan

Nameq

2022

J of Cosmetic Dermatology

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Background: Melanin from different sources is widely used by many manufacturers to produce cosmetics and sunscreens. Research data show a wide spectrum of biological activities of melanin including the protection against UV radiation and oxidants. According to the research evidence, the topical use of melanin is more effective against inflammation than the hydrocortisone. The most common side effects of topical melanin ointment are local itching, burning, and moderate hyperemia.Aim of the study: The purpose of this work is to describe the adverse outcomes of melanin-containing formulas in patients with solar dermatitis, and to compare the frequency of adverse reactions with data from different research reports. Methods:A Pharmacovigilance questionnaire was developed to assess potential adverse events attributable to the use of melanin ointment. We used a modified survey tool created by Jaber and coauthors. This survey of melanin application documents validated reports of adverse events manifested by objective skin changes. MEDLINE (Ovid); MEDLINE In-Process Citations & Daily Update (Ovid); PubMed (NLM) (Internet); Embase (Ovid); and Cochrane Database of Systematic Reviews were searched for the evidence on adverse reactions of topical melanin application. Results:The responses documented in this survey show reliability and safety of melanin formula used for the photoprotection and treatment of solar dermatitis. Most symptoms encountered in those using melanin were consistent with exposure to excessive amount (more than 4 times per day) of the compound applied topically. Of the total 534 survey responses received, 74% reported no adverse events. A total of 140 completed adverse event reports. Melanin ointment was being administered for the indications of photo injury (burns) in 75%, photodermatitis in 18%, and solar eczematous dermatitis in 7% of patients. Data were compared with rates from other reports. Conclusion:We have no evidence that the chemical structure of melanin varies with currently available products, used locally or in other countries, nor that any such variability played any role in the events reported here. Further studies are required to compare the adverse events of topical melanin formulas containing melanins of different origin.

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Section: Discussionmentioning

confidence: 99%

“…However, the safety issues are of primary interest. Bacterial melanin produced in biotechnology Institute of Armenia is one of the options and possesses clinical and pharmaceutical perspectives 25–27 . The number of melanin‐containing ointments and creams continues to grow, increasing the potential risk for adverse reactions.…”

Section: Discussionmentioning

confidence: 99%

Assessing the frequency of adverse reactions induced by melanin‐containing formulations used for the management of solar dermatitis

Petrosyan

Nameq

2022

J of Cosmetic Dermatology

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“…Melanin promotes chemical transport, resulting in faster nerve impulses and further acting as neuroprotection [ 25 ]. These particular features of melanin elucidate their incidence in organs, and tissues that are connected with impulse transmission systems, like body skin, nervous system, and retina [ 26 ].…”

Section: Applications Of Melaninmentioning

confidence: 99%

“…Moreover, bacterial melanin has been evaluated as a strong activator of regeneration and motion recovery in rat models subjected to unilateral depletion of the substantia nigra pars compacta. It stimulates the healing of a damaged motion tract and the regeneration of a damaged peripheral nerve fiber, produces capillary dilatation in the lesion area, and so improves blood flow in brain tissue [ 25 , 28 ]. Another protective mechanism of neuromelanin pigments is that they attach and sequester the toxic metals to form stable complexes that prevent neuronal toxicity [ 27 ].…”

Section: Applications Of Melaninmentioning

confidence: 99%

Natural Melanin: Current Trends, and Future Approaches, with Especial Reference to Microbial Source

El‐Naggar

Saber

2022

Polymers

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Melanin is a universal natural dark polymeric pigment, arising in microorganisms, animals, and plants. There is a couple of pieces of literature on melanin, each focusing on a different issue, the goal of the present review is to focus on microbial melanin. It has numerous benefits with very few drawbacks. The current situation and expected trends are discussed. Intriguing, numerous studies have provoked a serious necessity for a comprehensive assessment of microbial melanin pigments. So that, such review would help scholars from diverse backgrounds to realize the importance of melanin pigments isolated from microorganisms, with this aim in mind, information, and hypothesis from this review could be the paradigm for studies on melanin in the next era.

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“…BM was obtained on the basis of the production strain of Bacillus thuringiensis under the action of nitrosoguanidine. The water-soluble BM obtained through biotechnological means holds potential as a biological medical product for the treatment of neurodegenerative diseases, including PD [ 15 ]. The molecular weight of the purified melanin determined by SDS-PAGE was 4 kDa and the electromagnetic spin resonance spectrum of the purified microbial melanin was a slightly asymmetric singlet without hyperfine structure with about 7 Gauss width of the line between points of the maximum incline and g = 2.006.…”

Section: Introductionmentioning

confidence: 99%

Regulatory effect of bacterial melanin on the isoforms of new superoxide-producing associates from rat tissues in rotenone-induced Parkinson’s disease

Danielyan,

Nebogova,

Simonyan

et al. 2023

BMC Neurosci

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According to recent research, selective neuronal vulnerability in Parkinson’s disease (PD) results from several phenotypic traits, including calcium-dependent, feed-forward control of mitochondrial respiration leading to elevated reactive oxygen species and cytosolic calcium concentration, an extensive axonal arbor, and a reactive neurotransmitter. Therefore, antioxidant therapy is a promising direction in the treatment of PD. In vitro studies have indicated the survival-promoting activity of bacterial melanin (BM) on midbrain dopaminergic neuron cultures. It has been established that BM has a number of protective and anti-inflammatory properties, so there is a high probability of a protective effect of BM in the early stages of PD. In this study, PD was induced through the unilateral intracerebral administration of rotenone followed by bacterial melanin. Tissues (brain, lungs, and small intestine) from the observed groups underwent isolation and purification to extract isoforms of new thermostable superoxide (О2−)-producing associates between NADPH-containing lipoprotein (NLP) and NADPH oxidase-Nox (NLP-Nox). The optical absorption spectral characteristics, specific amounts, stationary concentration of the produced О2−, and the content of NADPH in the observed associates were determined. The optical absorption spectra of the NLP-Nox isoforms in the visible and UV regions in the experimental groups did not differ from those of the control group. However, compared with the control group, the specific content of the total fractions of NLP-Nox isoforms associated with PD groups was higher, especially in the small intestine. These findings suggest that the described changes may represent a novel mechanism for rotenone-induced PD. Furthermore, bacterial melanin demonstrated antioxidant properties and regulated membrane formation in the brain, lung, and small intestine. This regulation occurred by inhibiting the release of new membrane-bound formations (NLP-Nox associates) from these membranes while simultaneously regulating the steady-state concentration of the formed О2−.

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Bacterial melanin in rat models of Parkinson′s disease: a potential neuroprotective strategy

Cited by 6 publications

References 7 publications

Assessing the frequency of adverse reactions induced by melanin‐containing formulations used for the management of solar dermatitis

Assessing the frequency of adverse reactions induced by melanin‐containing formulations used for the management of solar dermatitis

Natural Melanin: Current Trends, and Future Approaches, with Especial Reference to Microbial Source

Regulatory effect of bacterial melanin on the isoforms of new superoxide-producing associates from rat tissues in rotenone-induced Parkinson’s disease

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