Bacterial Lactoferrin Receptors

Lactoferrin: a review

“…Nevertheless, some bacteria are able to adapt to the new conditions and release siderophores (iron chelating compounds of bacterial origin) that compete with lactoferrin for Fe 3+ ions (Crosa, 1989;Ratledge and Dover, 2000). Some other types of bacteria, including Neisseriaceae family, adapt to new conditions by expressing specific receptors capable of binding lactoferrin, and to cause changes in the tertiary structure of the lactoferrin molecule leading to iron dissociation (Schryvers et al, 1998;Ekins et al, 2004).…”

Identification of a conserved Moraxella catarrhalis haemoglobin-utilization protein, MhuA

“…Whilst it is assumed that this pathogen has many mechanisms that are similar to those of other human mucosal pathogens, the only systems that have been reported involve iron acquisition through the use of transferrin, lactoferrin and haem (Campagnari et al, 1994;Furano & Campagnari, 2004;Schryvers et al, 1998;Stojiljkovic et al, 1996). As stated previously, iron is an essential element that is required for growth and metabolism of most bacteria and understanding the strategies of iron uptake for M. catarrhalis will provide important information relating to the ability of this pathogen to colonize and survive on host tissues.…”

“…Whilst it has previously been shown that this M. catarrhalis strain expresses transferrin-and lactoferrin-receptor systems and can utilize these iron-carrier proteins for growth, the actual mechanism as to how these systems function has not been clearly defined (Campagnari et al, 1994;Schryvers et al, 1998). It was initially thought that these proteins probably function in the same manner as the other, well-studied transferrin and lactoferrin receptors.…”

“…It is well-established that, like most other organisms, M. catarrhalis has a strict requirement for iron (Campagnari et al, 1994(Campagnari et al, , 1996Furano & Campagnari, 2003;. M. catarrhalis can obtain iron for growth and metabolism through the binding of either transferrin or lactoferrin, two of the human iron-binding proteins (Campagnari et al, 1994;Schryvers et al, 1998;Stojiljkovic et al, 1996). These two specific receptor systems are similar in composition, with an integral outermembrane protein (OMP) component and an outermembrane lipoprotein component that work together to bind the iron-carrier protein and internalize the iron moiety.…”

Detection of Bovine Lactoferrin Binding Protein on Jurkat Human Lymphoblastic T Cell Line

“…Lactoferrin-binding proteins have been found on the surface of various cells, including hepatocytes, erythro-leukemic cells, monocytes, peritoneal macrophages, activated Tcells and platelets, and on the surface of various microorganisms [6,20]. Lf receptors have also been found on the intestinal brush border [12,13,18,22].…”