Bacterial endotoxin and infection cause behavioural hypothermia in infant mice

Behavioral thermoregulation in mice inoculated with influenza virus

“…Similar to our results, other studies have shown that mice decrease thermoregulatory set point (seek cooler temperatures in a gradient) and/or show increased survivorship at lower ambient temperatures when injected with toxic substances [e.g., (1,4,5,17)]. An experiment by Lagerspetz and V~fithinen (12) showed that lowered temperature can increase survival rate of mice. In that study, young mice were infected with bacteria or with endotoxin.…”

“…A previous study (12) has shown that lowered temperatures increased survival to bacteria or endotoxin challenge in young mice. The reduction in Tb in virus-infected mice may be a regulated response that has adaptive value (i.e., improves survival).…”

Behavioral thermoregulation in mice inoculated with influenza virus

“…Similar to our results, other studies have shown that mice decrease thermoregulatory set point (seek cooler temperatures in a gradient) and/or show increased survivorship at lower ambient temperatures when injected with toxic substances [e.g., (1,4,5,17)]. An experiment by Lagerspetz and V~fithinen (12) showed that lowered temperature can increase survival rate of mice. In that study, young mice were infected with bacteria or with endotoxin.…”

“…A previous study (12) has shown that lowered temperatures increased survival to bacteria or endotoxin challenge in young mice. The reduction in Tb in virus-infected mice may be a regulated response that has adaptive value (i.e., improves survival).…”

Behavioral anapyrexia as a response to virus infection in a poikilothermic vertebrate

“…Behavioral anapyrexia 42,43 , previously referred to as 'behavioral chill' or 'coldseeking behavior' was first documented in arthropods and was suggested to be a form of antipathogen behavioral defense [44][45][46][47] . Similarly, the term 'behavioral hypothermia' has been reported in mice during bacterial infection 48 and in amphibians as a beneficial response to hypoxia, rather than as an anti-pathogen behavioral defense 49 . The evolution of behavioral anapyrexia in agile frogs in response to FV3 may be explained by the warm-adapted nature of the virus, as in vitro studies have shown that FV3 reaches its highest titers at 30 °C 27,28 .…”

Pathophysiology of unilateral pulmonary aspergillosis in an experimental rat model

“…The multiplication and pathogenicity of many infectious agents is also suppressed at low and not only at high temperature. Therefore, it has been suggested that in small animals cryexia may be an alternative to fever for coping with infections [13].…”

Behavioral thermoregulation in mice inoculated with influenza virus

“…Similar to our results, other studies have shown that mice decrease thermoregulatory set point (seek cooler temperatures in a gradient) and/or show increased survivorship at lower ambient temperatures when injected with toxic substances [e.g., (1,4,5,17)]. An experiment by Lagerspetz and V~fithinen (12) showed that lowered temperature can increase survival rate of mice. In that study, young mice were infected with bacteria or with endotoxin.…”

“…A previous study (12) has shown that lowered temperatures increased survival to bacteria or endotoxin challenge in young mice. The reduction in Tb in virus-infected mice may be a regulated response that has adaptive value (i.e., improves survival).…”

Behavioral anapyrexia as a response to virus infection in a poikilothermic vertebrate

“…Behavioral anapyrexia 42,43 , previously referred to as 'behavioral chill' or 'coldseeking behavior' was first documented in arthropods and was suggested to be a form of antipathogen behavioral defense [44][45][46][47] . Similarly, the term 'behavioral hypothermia' has been reported in mice during bacterial infection 48 and in amphibians as a beneficial response to hypoxia, rather than as an anti-pathogen behavioral defense 49 . The evolution of behavioral anapyrexia in agile frogs in response to FV3 may be explained by the warm-adapted nature of the virus, as in vitro studies have shown that FV3 reaches its highest titers at 30 °C 27,28 .…”

Pathophysiology of unilateral pulmonary aspergillosis in an experimental rat model

“…The multiplication and pathogenicity of many infectious agents is also suppressed at low and not only at high temperature. Therefore, it has been suggested that in small animals cryexia may be an alternative to fever for coping with infections [13].…”

Behavioral thermoregulation in mice inoculated with influenza virus

“…Similar to our results, other studies have shown that mice decrease thermoregulatory set point (seek cooler temperatures in a gradient) and/or show increased survivorship at lower ambient temperatures when injected with toxic substances [e.g., (1,4,5,17)]. An experiment by Lagerspetz and V~fithinen (12) showed that lowered temperature can increase survival rate of mice. In that study, young mice were infected with bacteria or with endotoxin.…”

“…A previous study (12) has shown that lowered temperatures increased survival to bacteria or endotoxin challenge in young mice. The reduction in Tb in virus-infected mice may be a regulated response that has adaptive value (i.e., improves survival).…”

Behavioral anapyrexia as a response to virus infection in a poikilothermic vertebrate

“…Behavioral anapyrexia 42,43 , previously referred to as 'behavioral chill' or 'coldseeking behavior' was first documented in arthropods and was suggested to be a form of antipathogen behavioral defense [44][45][46][47] . Similarly, the term 'behavioral hypothermia' has been reported in mice during bacterial infection 48 and in amphibians as a beneficial response to hypoxia, rather than as an anti-pathogen behavioral defense 49 . The evolution of behavioral anapyrexia in agile frogs in response to FV3 may be explained by the warm-adapted nature of the virus, as in vitro studies have shown that FV3 reaches its highest titers at 30 °C 27,28 .…”

Pathophysiology of unilateral pulmonary aspergillosis in an experimental rat model

“…The multiplication and pathogenicity of many infectious agents is also suppressed at low and not only at high temperature. Therefore, it has been suggested that in small animals cryexia may be an alternative to fever for coping with infections [13].…”