Bacterial Adherence to Different Meshes Used in Abdominal Surgery

Abstract

Depending on the type of bacteria, collagen-coated hydrophilic prostheses with a large surface increased bacterial adherence significantly. These differences should be taken into consideration when choosing a mesh graft, which limits infection in abdominal wall reconstruction.

Bacterial adhesion to biological versus polymer prosthetic materials used in abdominal wall defect repair: do these meshes show any differences in vitro?

“…Our results showed that, despite no significant differences, the numbers of bacteria adhered to the surface of the PP meshes were lower for Op than Surg. This finding is consistent with those reported by others [17,18] who have shown that macroporous PP meshes display less bacterial adhesion than materials with a smaller pore size. Interestingly, both PP meshes showed the significantly greater adhesion of both strains than Precl.…”

“…This means that biosynthetic prosthetic implants show similar in vitro behaviour in response to infection. This has also been observed by other authors for composite meshes [18,20], which usually induce higher bacterial loads than non-absorbable polymer implants despite having a surface biodegradable film.…”

“…Although many authors have examined the in vitro adhesion of several bacterial strains to PP, PE and ePTFE [5,17,18,[20][21][22][23], bacterial adhesion to biological meshes has been much less investigated. As far as we are aware, only one in vitro investigation has addressed bacterial adhesion to biomeshes compared to polymer meshes [24].…”

“…Firstly, we have utilized high Sa and Se doses (10 6 CFU) to provoke an acute contamination of the meshes, approximately 4-logs higher than the bacteril load able to trigger a prosthetic mesh infection in patients [23]. Secondly, the hydrophilic surface of the absorbable materials promotes a higher bacterial adherence than the hydrophobic surface of the PP and ePTFE meshes [18]. And thirdly, the complex architecture of the synthetic absorbable meshes enhances the bacterial adhesion [5] as well as the presence of vascular canals and interstices along the biomeshes [15], and contrary to the non-absorbable PP and non-porous ePTFE materials.…”

Bacterial adhesion on biomedical surfaces covered by yttria stabilized zirconia

“…The main pathogenic factor of prosthetic joint infections is the development of a bacterial biofilm. This structure allows bacteria to resist antimicrobial agents and immune responses [5], so patients with this type of infection require a longer period of antibiotic therapy and repeated surgical procedures [6,7].…”