Bacteremia caused by the novel species Mycobacterium canariasense

Campos-Herrero, María Isolina; García, Diana; Figuerola, Ariadna; Suárez, José P.; Campo, C; García, María Jesús García

doi:10.1007/s10096-005-0079-6

Cited by 21 publications

(15 citation statements)

References 9 publications

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“…Similar to other rapidly growing nontuberculous mycobacteria (NTM), M. canariasense is presumed to be an environmental agent that may act as an opportunistic pathogen. From the original case series published in 2004, 12 of 17 patients had an underlying malignancy such as lym- phoma, leukemia, or multiple myeloma as well as other soft tissue tumors (7). Furthermore, 11 of these patients had undergone antineoplastic chemotherapy and had received parenteral antibiotic therapy via a central venous catheter (7).…”

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confidence: 99%

“…From the original case series published in 2004, 12 of 17 patients had an underlying malignancy such as lym- phoma, leukemia, or multiple myeloma as well as other soft tissue tumors (7). Furthermore, 11 of these patients had undergone antineoplastic chemotherapy and had received parenteral antibiotic therapy via a central venous catheter (7). Like the majority of these cases, our patient had recently been diagnosed with a malignancy (diffuse large B cell lymphoma) and was undergoing his second cycle of chemotherapy when he first developed fever.…”

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First Report of Mycobacterium canariasense Catheter-Related Bacteremia in the Americas

et al. 2014

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e Mycobacterium canariasense is a recently described late-pigmenting, rapidly growing mycobacterium linked to bacteremia in patients with underlying malignant diseases. We report a case of M. canariasense infection in a patient from Massachusetts with underlying diffuse B cell lymphoma, which was identified both by multilocus sequence typing and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). To our knowledge, this is the first description after its original identification in Spain and the first report of this opportunistic pathogen in the Americas. CASE REPORT We report a case of catheter-related bacteremia by Mycobacterium canariasense in a 42-year-old patient from Massachusetts with a history of intravenous drug abuse, hepatitis C, and diffuse B cell lymphoma.The patient presented complaining of fever (101.2°F), chills, vomiting, and nausea since 2 days prior to his admission. Six weeks earlier, he had been admitted and diagnosed with presumptive osteomyelitis of the sacroiliac joint for which he received empirical treatment with intravenous vancomycin for 6 weeks, completed a week prior to admission. Multiple sets of blood cultures were negative during this admission. At that time, a bone marrow biopsy was also performed for pancytopenia, and the patient was diagnosed with diffuse large B cell lymphoma with plasmacytoid features. He received two cycles of antineoplastic chemotherapy with cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisolone (R-CHOP), with the second cycle administered 2 days prior to admission and coinciding with the onset of fever.He did not report rashes, headache, cough, or gastrointestinal complaints, and his prior medical history was significant for bipolar and major depressive disorder as well as essential hypertension. Liver function tests were monitored for hepatitis C exacerbation but were within reference limits. A complete blood count was notable for total leukocytes of 5,150/mm 3 , with 50.5% neutrophils and 16.8% lymphocytes, decreased hemoglobin of 8.6 g/dl, hematocrit of 31.2%, and a normal platelet count of 381,000/mm 3 . Blood urea nitrogen, serum creatinine, and glucose were within reference ranges.Shortly after admission during a febrile episode, blood cultures were drawn and the peripherally inserted central catheter was removed and sent for culture using the roll-plate semiquantitative technique described by Maki et al. (1). The blood cultures in the aerobic bottles grew Candida dubliniensis, Candida albicans, Pseudomonas aeruginosa, and numerous Gram-variable rods. Candida species were determined with both the API 20C AUX and matrixassisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) systems. The catheter tip grew numerous Gram-variable rods as well as a group B beta-streptococcus.The Gram-variable rods (which grew from 4/4 bottles collected in two sets 3 days apart) grew on Lowenstein-Jensen (LJ) medium after 4 days (at 37°C) and revealed small, smooth, nonpigmented coloni...

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First Report of Mycobacterium canariasense Catheter-Related Bacteremia in the Americas

et al. 2014

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“…The pathogenicity of M. cosmeticum was further demonstrated in additional cases whereby the bacterium was responsible for pulmonary disease, catheter-associated bacteremia and most recently as a colitogenic agent [ 16 , 17 ]. M. canariasense , akin to M. cosmeticum , is an opportunistic pathogen linked to bacteremia in patients with underlying malignant diseases [ 12 , 13 , 18 ]. Therefore, it is not inconceivable that NTM165, being related to these two species, has also pathogenic potential.…”

Section: Discussionmentioning

confidence: 99%

A NovelMycobacterium cosmeticum-Like Bacterium Isolated from the Ear Swab of a Patient with Otitis Externa

Teo

Cheng

Jureen

et al. 2015

Case Reports in Infectious Diseases

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We describe the identification and characterization of a novel nontuberculous mycobacterium (NTM), isolated from an ear swab of an adult male patient with chronic otitis externa. Genetically, the bacterium is most closely related to Mycobacterium cosmeticum; however, growth and biochemical features indicate that it is distinctly different. Here, we highlight for the first time an unusual NTM that is a probable cause of ear infection.

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“…The characterization of this mycobacterium, in 2004, was based on a cluster of strains isolated from blood cultures via indwelling catheters from patients with probable nosocomial infection in the Canary Islands, Spain [7,8]. It was also isolated from respiratory sources but the pulmonary infection was deemed possible to doubtful in a patient primary diagnosed with cancer [9].…”

Section: Discussionmentioning

confidence: 99%

Mycobacterial infection of breast prosthesis – a conservative treatment: a case report

et al. 2014

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BackgroundBacterial infection is a well-known risk of breast implant surgery. It is typically caused by bacterial skin flora, specifically Staphylococcus aureus and the coagulase negative staphylococci. There have been infrequent reports of breast implant infection caused by the atypical mycobacteria, of which Mycobacterium canariasense not yet reported in the literature.Case presentationThis report summarizes the case of a female patient who underwent mastectomy followed by bilateral breast augmentation and presented approximately three years later with clinical evidence of infected breast prosthesis by Mycobacterium canariasense. One year after thoroughly follow-up, appropriate antibiotherapy and the change of the infected prosthesis, the patient presented no signs of reinfection.ConclusionOur case demonstrates that Mycobacterium canariasense should be considered as a new potential cause of infected breast prosthesis.

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Bacteremia caused by the novel species Mycobacterium canariasense

Cited by 21 publications

References 9 publications

First Report of Mycobacterium canariasense Catheter-Related Bacteremia in the Americas

First Report of Mycobacterium canariasense Catheter-Related Bacteremia in the Americas

A NovelMycobacterium cosmeticum-Like Bacterium Isolated from the Ear Swab of a Patient with Otitis Externa

Mycobacterial infection of breast prosthesis – a conservative treatment: a case report

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