Bacteraemia in Intensive Care Unit: Clinical, Bacteriological, and Prognostic Prospective Study

Lachhab, Zineb; Frikh, Mohammed; Maleb, Adil; Kasouati, Jalal; Doghmi, Nouafal; Lahlou, Yassine Ben; Belefquih, Bouchra; Lemnouer, Abdelhay; Elouennass, Mostafa

doi:10.1155/2017/4082938

Cited by 25 publications

(29 citation statements)

References 24 publications

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“…Ibrahim observed in 2018 that 81% of the isolates were Gram-negative, and male patients (59.7%) were predominant in that study [9]. The predominance of Gram-negative isolates in older male patients admitted to ICUs has been observed in studies conducted by Bianco et al, Sligl et al, and Lachhab et al [19][20][21]. Males are generally more prone to infections than females, due to differences in the sex steroids as well as imbalance of sex-chromosomelinked genes [22].…”

Section: Discussionmentioning

confidence: 72%

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Resistance Patterns of Gram-Negative Bacteria Recovered from Clinical Specimens of Intensive Care Patients

et al. 2021

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Intensive care units are complex environments favoring high resistance in microorganisms. This study evaluated the resistance and the distribution dynamics of resistant Gram-negative bacteria (GNB) in patients admitted to intensive care units. This retrospective, record-based, cross-sectional study analyzed all of the antibiograms of patients admitted to the ICUs. The BD Phoenix system (BD Diagnostics, Sparks, MD, USA) was used for bacterial identification and antimicrobial testing. Clinical and Laboratory Standard Institute recommendations were used for antimicrobial testing. Frequencies and percentages of multidrug and pan-drug resistance were calculated. A total of 570 bacterial growths were observed, out of which 437 (76.7%) were of GNB. K. pneumoniae (21.0%), P. aeruginosa (11.8%), and Staphylococcus aureus (13.2%) were the most frequent disease-causing bacteria in intensive care patients. Resistance rates of 73.2% and 70.1% were observed for third- and fourth-generation cephalosporins, respectively, while 48.2% carbapenem and > 65% fluoroquinolones resistance rates were observed. Amikacin was the most effective antibiotic, with a sensitivity rate of 69.5%. A total of 372 (85.1%) of GNB were multidrug resistant. The majority of infections in intensive care patients are caused by multidrug-resistant (MDR) Gram-negative bacteria. Female gender and advancing age are factors favoring MDR. Enhanced surveillance and strengthening of the antimicrobial stewardship program are warranted.

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Section: Discussionmentioning

confidence: 72%

“…Males are generally more prone to infections than females, due to differences in the sex steroids as well as imbalance of sex-chromosomelinked genes [22]. The increased incidence in older age groups may be due to their defective defense mechanisms and deteriorating immune systems [21,23].…”

Section: Discussionmentioning

confidence: 99%

Resistance Patterns of Gram-Negative Bacteria Recovered from Clinical Specimens of Intensive Care Patients

et al. 2021

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“…A study which analyzed bloodstream infections showed that Acinetobacter baumannii was the most commonly encountered Gram negative agent by 23.6%. Incidence of Staphylococcus aureus and Methicillin resistant staphylococcus aureus were 9.1% and 20%, respectively (30). The most commonly determined agents were Acinetobacter baumannii (20.7%) and Klebsiella pneumoniae (19.1%) in our study.…”

Section: Discussionmentioning

confidence: 44%

The Relationship Between Sepsis Foci and Procalcitonin Values in Intensive Care Patients

Kara¹,

Undar²,

Seven³

et al. 2020

Crit Intensive Care

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Background: Anatomic localizations of septic foci and the relationship between these localizations and procalcitonin (PCT) in the clinical picture of sepsis/septic shock induced by these foci is not a sufficiently investigated topic. We aimed to determine the relationship between sepsis foci and procalcitonin values in intensive care patients. Methods: Data of the patients who were admitted in the intensive care unit and diagnosed with sepsis/ septic shock between 2016 and 2018 were analyzed retrospectively. The patients were grouped based on the localization of the infectious foci as respiratory system, urinary system, blood-catheter, soft tissue and abdominal. Additionally, the patients were grouped also based on number of foci and growing microorganisms. Subsequently, the relationship between septic foci and routine laboratory parameters, primarily PCT, was investigated statistically. Results: Totally 630 infection periods were analyzed in 424 patients who were diagnosed with sepsis/septic shock in the intensive care unit. Incidence of sepsis/septic shock was 36.5% while mortality rate was 65.6% in these patients. A higher mortality rate was encountered in the infections with two or multiple foci (p <0.001). Multiple-focal infections revealed higher PCT values than the single focal infections (p = 0.021). A higher mortality rate was detected in the patients with microbial growth in the respiratory infections than those with urinary and abdominal infections (p <0.001). The patients with microbial growth reported from blood and abdominal cultures revealed higher PCT levels than other patients groups (p <0.001). Conclusions: Higher procalcitonin levels are related to presence of multiple foci of infection and, as well, to higher mortality rates.

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“…In four of the studies, all needed variables were easily retrieved from the tables, and these studies were included immediately. Crucial characteristics, comments and result are given in Table 1 for these four and the remaining 17 studies that were subjected to the final quality check [3, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44. Six of these 17 studies were included following cross-check of text and tables.…”

Section: Resultsmentioning

confidence: 99%

“…91 ICUs, 28 Hospitals in Egypt.NICU, Paediatric, Medical, Surgical, Neurological2012-14Microbes and susceptibility results given for all types of samples/specimen in one. Not inclued CLSINGNGNGNG-[42]LachhabMoroccoMohammed V Military Teaching HospitalICU2012 - 13 Included NG45255729+[38]MittEstoniaPICU, Tartu University HospitalPICU2004-8 Included CLSI47392311+[43]HorcajadaSpain8 Spanish ICUsUnselected sepsis patients2010-11Author’s clarification about number of Acintobacter isolates. Included CLSI371339131+[33]BartolettiItalyOrsola-Malpighi Hospital Bologna, Italy8874 patients with cirrhosis2008-12Missing test results provided by author.…”

Section: Resultsmentioning

confidence: 99%

Association between antimicrobial resistance among Enterobacteriaceae and burden of environmental bacteria in hospital acquired infections: analysis of clinical studies and national reports

Henriksen

Abebe

Amogne

et al. 2019

Heliyon

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Background WHO has named three groups of gram-negative bacteria “our critical antimicrobial resistance-related problems globally”. It is thus a priority to unveil any important covariation of variables behind this three-headed epidemic, which has gained alarming proportions in Low Income Countries, and spreads rapidly. Environmental bacteria including Acinetobacter spp. are common nosocomial pathogens in institutions that have high rates of antimicrobial resistance among other groups of gram-negative bacteria. Methods Based on two different data sources, we calculated the correlation coefficient (Pearson's r ) between pathogenic burden of Acinetobacter spp. and antimicrobial resistance among Enterobacteriaceae in European and African nosocomial cohorts. Clinical reports Database search for studies on nosocomial sepsis in Europe and Africa was followed by a PRISMA-guided selection process. National reports Data from Point prevalence survey of healthcare-associated infections published by European Centre for Disease Prevention and Control were used to study the correlation between prevalence of Acinetobacter spp. and antimicrobial resistance among K. pneumoniae in blood culture isolates. Findings The two approaches both revealed a strong association between prevalence of Acinetobacter spp. and rates of resistance against 3. generation cephalosporins among Enterobacteriaceae. In the study of clinical reports (13 selected studies included), r was 0.96 (0.80–0.99) when calculated by proportions on log scale. Based on national reports, r was 0.80 (0.56–0.92) for the correlation between resistance rates of K. pneumoniae and proportion of Acinetobacter spp. Interpretation The critical antimicrobial resistance-related epidemics that concern enteric and environmental gram-negative bacteria are not independent epidemics; they have a common promoting factor, or they are mutually supportive. Further, accumulation of antimicrobial resistance in nosocomial settings depends on the therapeutic environment. Burden of Acinetobacter spp. as defined here is a candidate measure for this dependence.

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Bacteraemia in Intensive Care Unit: Clinical, Bacteriological, and Prognostic Prospective Study

Cited by 25 publications

References 24 publications

Resistance Patterns of Gram-Negative Bacteria Recovered from Clinical Specimens of Intensive Care Patients

Resistance Patterns of Gram-Negative Bacteria Recovered from Clinical Specimens of Intensive Care Patients

The Relationship Between Sepsis Foci and Procalcitonin Values in Intensive Care Patients

Association between antimicrobial resistance among Enterobacteriaceae and burden of environmental bacteria in hospital acquired infections: analysis of clinical studies and national reports

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