2016
DOI: 10.18632/aging.100913
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Abstract: Standardized extracts of Bacopa monniera (BME) have been shown to exert a neuroprotective effect against mental diseases, such as depression, anxiety and Alzheimer's disease (AD), in chronic administration studies. However, its mechanism of action has remained unclear. In this study, we evaluated the therapeutic effect of Bacopaside I (BS-I), a major triterpenoid saponin of BME, on the cognitive impairment and neuropathology in APP/PS1 transgenic mice and explored the possible mechanism from a biological syste… Show more

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Cited by 12 publications
(5 citation statements)
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References 43 publications
(39 reference statements)
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“…Some triterpenoid saponins have shown to reduce scopolamine-induced amnesia [6][7][8] and non-selective and selective muscarinic agonists have shown to improve learning and memory. Selective M1 muscarinic agonists are a pivotal target that link major hallmarks of AD.…”
Section: The Cholinergic Hypothesismentioning
confidence: 99%
“…Some triterpenoid saponins have shown to reduce scopolamine-induced amnesia [6][7][8] and non-selective and selective muscarinic agonists have shown to improve learning and memory. Selective M1 muscarinic agonists are a pivotal target that link major hallmarks of AD.…”
Section: The Cholinergic Hypothesismentioning
confidence: 99%
“…To determine whether intranasal delivery of 9-cis RA affects amyloid pathology, we treated 6-month-old APP/PS1 mice for a period of 4 weeks, as these mice are known to develop amyloid plaques at 5 to 6 months [16]. The brain sections were immunostained with an anti-Aβ antibody (82E1), and the extent of Aβ deposition in the cortical and hippocampal brain regions of APP/PS1 mice was captured by confocal microscopy ( Figure 1A).…”
Section: -Cis Ra Reduces Aβ Deposition In An Amyloid Mouse Modelmentioning
confidence: 99%
“…In animal models, Bacopa monnieri extracts improve cognitive functions mainly through protective action on hippocampal neurons and partly through promoting neuroregeneration in the dentate gyrus (18,19). Furthermore, studies on APP/PS1 mice have shown that Bacopia monnieri extracts can reduce plaque load and enhance plaque clearance, possibly via phagocytosis (20). Bacopa monnieri prevents senescence and has an anti-apoptotic effect in brain astrocytes and, therefore, is thought to combat brain pollution and age-related neurological disorders (21).…”
Section: Neuroprotective Effects Of Bacopamentioning
confidence: 99%