Baclofen reduces binge frequency

Corwin, Rebecca L.; Boan, Jarol; Peters, Kristi L.; Walsh, B. Timothy; Ulbrecht, Jan S.

doi:10.1016/j.appet.2010.04.049

Cited by 6 publications

(9 citation statements)

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“…Specifi cally, the ␥-aminobutyric (GABA)-B agonist baclofen reduced bingetype intake in rats (Buda-Levin et al 2005) as well as in open-label and placebo-controlled trials in humans (Broft et al 2007;Corwin et al 2010). Others have used this model with modifi cations to the optional food provided, the intermittent access schedule, the length of time the palatable food was available, and the species (Berner et al 2009;Czyzyk et al 2010;Davis et al 2007;Kinzig et al 2008;McGee et al 2010).…”

Section: Intermittent Access (Corwin)mentioning

confidence: 97%

Rodent Models of Binge Eating: Are They Models of Addiction?

Corwin¹,

Babbs²

2012

ILAR Journal

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Are recently developed rodent models of binge eating also models of food addiction? Valid models should meet human criteria for both bingeing and substance dependence as described in the 4th edition and proposed for the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM). Similarly, behavioral profiles of bingeing animals should share characteristics with those of animal models of drug addiction. We evaluate and discuss current rodent models of bingeing, their contributions to scientific understanding of bingeing, their validity with respect to DSM criteria, and their overlap with models of addiction. The models described indicate that repeated intermittent bouts in which large quantities of fatty or sugary foods are consumed (binges) are associated with behavioral changes similar to those described for drugs of abuse. In contrast, control groups consuming the same foods in a nonbinge-type manner do not exhibit an "addiction-like" behavioral profile. Thus, fatty/sugary foods in and of themselves do not appear to have addictive qualities. Rather, the manner in which they are consumed appears to be critical. In addition, while rodent models of bingeing and drug self-administration share similarities, we do not support reclassifying the bingeing-related eating disorders as substance use disorders because of differences that distinguish such disorders in humans.

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Section: Intermittent Access (Corwin)mentioning

confidence: 97%

Rodent Models of Binge Eating: Are They Models of Addiction?

Corwin¹,

Babbs²

2012

ILAR Journal

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“…Baclofen may prove useful clinically to help reduce the consumption of these types of foods. Indeed, recent reports suggest the usefulness of baclofen to reduce binge eating, although the specific foods consumed were not reported (Broft et al, 2007; Corwin et al, 2010). …”

Section: Discussionmentioning

confidence: 99%

“…In addition, baclofen has been shown to decrease self-reported bingeing bouts in human clinical trials (Broft et. al., 2007; Corwin et al, 2010). It is important to note, however, that while the baseline argument has appeal, effects do not always hold if the food contains sucrose or if rats are food-deprived.…”

Section: Discussionmentioning

confidence: 99%

“…The effects of baclofen, therefore, appear to be baseline dependent (high intakes), as well as dependent upon the composition of the food (high-fat) and the deprivation state of the animal (non-deprived). This may account for the reported ability of baclofen to reduce binge eating (Broft et al, 2007; Corwin et al, 2010), a condition in which high intakes of fatty foods occur even in the absence of hunger (APA, 2000). …”

Section: Discussionmentioning

confidence: 99%

“…Baclofen is a GABA-B agonist that has been shown to reduce drug self-administration (e.g., Brebner et al, 2000) and solid vegetable shortening (fat) intake (Buda-Levin et al, 2005; Corwin & Wojnicki, 2009). In addition, baclofen has shown promise clinically in the treatment of binge eating (Broft et al, 2007; Corwin et al, 2010). In contrast to its effects on fat intake, baclofen stimulates consumption of foods containing complex carbohydrates (e.g.…”

Section: Introductionmentioning

confidence: 99%

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Fat emulsion composition alters intake and the effects of baclofen

Wang

Wojnicki

et al. 2011

Appetite

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Thickened oil-in-water emulsions are useful model foods in rat studies due to their high acceptance and similarity to foods consumed by humans. Previous work from this laboratory used oil-in-water emulsions thickened with a biopolymer blend containing starch. Intake and effects of baclofen, a GABA-B agonist that decreases fat intake and drug self-administration, were reported, but the contribution of starch was not assessed. In the present study, intake and effects of baclofen were assessed in rats using emulsions prepared with two fat types (32% vegetable shortening, 32% corn oil) and thickened with three biopolymer blends. One biopolymer blend contained starch and the other two did not. Daily 1-h intake of the vegetable shortening emulsion containing starch was significantly greater than the other emulsions. When starch was added to the emulsions originally containing no starch, intake significantly increased. Baclofen generally reduced intake of all emulsions regardless of starch content and stimulated intake of chow. However, effects were more often significant for vegetable shortening emulsions. This report: 1) demonstrates that products used to prepare thickened oil-in-water emulsions have significant effects on rat ingestive behavior, and 2) confirms the ability of baclofen to reduce consumption of fatty foods, while simultaneously stimulating intake of chow.

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Binge-Type Eating Induced by Limited Access to Optional Foods

Corwin

Wojnicki

2012

Neuromethods

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Baclofen reduces binge frequency

Cited by 6 publications

References 0 publications

Rodent Models of Binge Eating: Are They Models of Addiction?

Rodent Models of Binge Eating: Are They Models of Addiction?

Fat emulsion composition alters intake and the effects of baclofen

Binge-Type Eating Induced by Limited Access to Optional Foods

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