Baclofen for alcohol withdrawal

A Narrative Review of Current and Emerging Trends in the Treatment of Alcohol Use Disorder

“…While Baclofen monotherapy for AWS has not yet been proven effective [ 15 ], it is currently under investigation as a component of combination therapy. In a recent study [ 16 ] exploring the combination of baclofen and diazepam, researchers tested the efficacy of baclofen at 30 mg/day and 60 mg/day versus a placebo.…”

A Narrative Review of Current and Emerging Trends in the Treatment of Alcohol Use Disorder

“…While Baclofen monotherapy for AWS has not yet been proven effective [ 15 ], it is currently under investigation as a component of combination therapy. In a recent study [ 16 ] exploring the combination of baclofen and diazepam, researchers tested the efficacy of baclofen at 30 mg/day and 60 mg/day versus a placebo.…”

Baclofen and the Alcohol Withdrawal Syndrome-A Short Review

“…The Cochrane review on baclofen in alcohol withdrawal (22) rates the evidence of this study as low quality in view of the absence of blinding participants to the treatment. However, the authors point out that with the exception of slight initial improvements in anxiety in the diazepam group, the two arms performed similarly on outcome measures.…”

“…The Cochrane review (22) also regards this study as low quality, in particular in view of the high attrition rate and it was noted that the study period of 72 hours period was relatively short.…”

“…The Cochrane group uses very strict quality criteria for inclusion in their latest review (22), and included the 3 randomized controlled trials above with 141 participants. They also conclude that insufficient and low quality evidence prevents judgment on efficacy and / or safety of baclofen in AWS.…”

Management of Acute Alcohol Withdrawal Syndrome in Critically Ill Patients

“…Baclofen is a GABA B receptor agonist that retains its effects even in chronic alcoholics. 33,44 A series of small studies published from 2000-2007 reported a reduction in AWS symptoms in outpatients. One randomized doubleblind placebo-controlled study evaluating baclofen as adjunct treatment for AWS in 31 inpatients with a CIWA-Ar score of 11 or higher met our inclusion criteria.…”

A Narrative Review of Current and Emerging Trends in the Treatment of Alcohol Use Disorder

“…While Baclofen monotherapy for AWS has not yet been proven effective [ 15 ], it is currently under investigation as a component of combination therapy. In a recent study [ 16 ] exploring the combination of baclofen and diazepam, researchers tested the efficacy of baclofen at 30 mg/day and 60 mg/day versus a placebo.…”

Baclofen and the Alcohol Withdrawal Syndrome-A Short Review

“…The Cochrane review on baclofen in alcohol withdrawal (22) rates the evidence of this study as low quality in view of the absence of blinding participants to the treatment. However, the authors point out that with the exception of slight initial improvements in anxiety in the diazepam group, the two arms performed similarly on outcome measures.…”

“…The Cochrane review (22) also regards this study as low quality, in particular in view of the high attrition rate and it was noted that the study period of 72 hours period was relatively short.…”

“…The Cochrane group uses very strict quality criteria for inclusion in their latest review (22), and included the 3 randomized controlled trials above with 141 participants. They also conclude that insufficient and low quality evidence prevents judgment on efficacy and / or safety of baclofen in AWS.…”

Management of Acute Alcohol Withdrawal Syndrome in Critically Ill Patients

“…Baclofen is a GABA B receptor agonist that retains its effects even in chronic alcoholics. 33,44 A series of small studies published from 2000-2007 reported a reduction in AWS symptoms in outpatients. One randomized doubleblind placebo-controlled study evaluating baclofen as adjunct treatment for AWS in 31 inpatients with a CIWA-Ar score of 11 or higher met our inclusion criteria.…”

A Narrative Review of Current and Emerging Trends in the Treatment of Alcohol Use Disorder

“…While Baclofen monotherapy for AWS has not yet been proven effective [ 15 ], it is currently under investigation as a component of combination therapy. In a recent study [ 16 ] exploring the combination of baclofen and diazepam, researchers tested the efficacy of baclofen at 30 mg/day and 60 mg/day versus a placebo.…”

Baclofen and the Alcohol Withdrawal Syndrome-A Short Review

“…The Cochrane review on baclofen in alcohol withdrawal (22) rates the evidence of this study as low quality in view of the absence of blinding participants to the treatment. However, the authors point out that with the exception of slight initial improvements in anxiety in the diazepam group, the two arms performed similarly on outcome measures.…”

“…The Cochrane review (22) also regards this study as low quality, in particular in view of the high attrition rate and it was noted that the study period of 72 hours period was relatively short.…”

“…The Cochrane group uses very strict quality criteria for inclusion in their latest review (22), and included the 3 randomized controlled trials above with 141 participants. They also conclude that insufficient and low quality evidence prevents judgment on efficacy and / or safety of baclofen in AWS.…”

Management of Acute Alcohol Withdrawal Syndrome in Critically Ill Patients

“…Baclofen is a GABA B receptor agonist that retains its effects even in chronic alcoholics. 33,44 A series of small studies published from 2000-2007 reported a reduction in AWS symptoms in outpatients. One randomized doubleblind placebo-controlled study evaluating baclofen as adjunct treatment for AWS in 31 inpatients with a CIWA-Ar score of 11 or higher met our inclusion criteria.…”