B‐type natriuretic peptide measurement in heart failure

Spevack, Daniel M.; Schwartzbard, Arthur

doi:10.1002/clc.4960270903

Cited by 7 publications

(7 citation statements)

References 79 publications

(77 reference statements)

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“…The human BNP gene is located on chromosome 1 and is a single copy gene consisting of 3 exons and 2 introns whereas mouse BNP gene is located on chromosome 4 [42]. The BNP synthesized by cardiomyocytes (ventricles) as a pre-pro BNP is 134 amino acids in length and undergoes cleavage and modification by enzymes [43]. The enzymes, corin and furin are involved in the conversion of pro-BNP to BNP.…”

Section: Chemistry Structure and Regulation Of Gene Expression Anmentioning

confidence: 99%

“…Pre-pro BNP modification results in the formation of a signal peptide and a propeptide (pro BNP, 108 amino acids), that is stored as a mature hormone in the human heart [23, 43]. Finally, during secretion from the cardiomyocytes, pro BNP undergoes post-translational modification and is split at a ratio of 1:1 into the physiologically active form of BNP (32 amino acids) which forms C-terminal fragment, and another fragment of biologically inactive N-terminal fragment (NT pro BNP; 76 amino acids) [23, 43]. The plasma half-life of BNP is also very short (12–23 min) and the expression and secretion of BNP are regulated by various physiological factors [44].…”

Section: Chemistry Structure and Regulation Of Gene Expression Anmentioning

confidence: 99%

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The multifaceted role of natriuretic peptides in metabolic syndrome

Santhekadur

Kumar

Seneshaw

et al. 2017

Biomedicine & Pharmacotherapy

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Due to globalization and sophisticated western and sedentary lifestyle, metabolic syndrome has emerged as a serious public health challenge. Obesity is significantly increasing worldwide because of increased high calorie food intake and decreased physical activity leading to hypertension, dyslipidemia, atherosclerosis, and insulin resistance. Thus, metabolic syndrome constitutes cardiovascular disease, type 2 diabetes, obesity, and nonalcoholic fatty liver disease (NAFLD) and recently some cancers are also considered to be associated with this syndrome. There is increasing evidence of the involvement of natriuretic peptides (NP) in the pathophysiology of metabolic diseases. The natriuretic peptides are cardiac hormones, which are produced in the cardiac atrium, ventricles of the heart and the endothelium. These peptides are involved in the homeostatic control of body water, sodium intake, potassium transport, lipolysis in adipocytes and regulates blood pressure. The three known natriuretic peptide hormones present in the natriuretic system are atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and c-type natriuretic peptide (CNP). These three peptides primarily function as endogenous ligands and mainly act via their membrane receptors such as natriuretic peptide receptor A (NPR-A), natriuretic peptide receptor B (NPR-B) and natriuretic peptide receptor C (NPR-C) and regulate various physiological and metabolic functions. This review will shed light on the structure and function of natriuretic peptides and their receptors and their role in the metabolic syndrome.

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Section: Chemistry Structure and Regulation Of Gene Expression Anmentioning

confidence: 99%

Section: Chemistry Structure and Regulation Of Gene Expression Anmentioning

confidence: 99%

The multifaceted role of natriuretic peptides in metabolic syndrome

Santhekadur

Kumar

Seneshaw

et al. 2017

Biomedicine & Pharmacotherapy

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“…Natriüretik peptid (NP) ailesinden BNP; basınç artı-şına cevap olarak ventriküllerden salınması nedeniyle kardiyovasküler hastalıklarda uzun zamandır çeşitli kullanım alanları bulmuştur (16)(17)(18)(19)(20)(21): (1) BNP ölçümü için şu anda başlıca endikasyon olan kardiyak dispne tanısında; (2) yüksek riskli popülasyonda asemptomatik sol ventrikül disfonksiyonunu tespit etmede; (3) kalp yetmezliği tedavisinin etkinliğini izlemede; (4) kalp yetmezliği veya koroner arter hastalığında prognozu belirlemede kullanılmaktadır (22). Literatürde BNP ve NT-proBNP'nin kalp yetmezliğinin tespitinde yüksek tanı oranına sahip olduğuna dair birçok çalışma mevcuttur (23,24).…”

Section: Natriüretik Peptidlerunclassified

NT-proBNP AT DIAGNOSIS OF PLEURAL EFFUSIONS DUE TO HEART

Bayram¹

2012

Plev Bult

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ÖzetKalp yetmezliğine bağlı plevral efüzyonun tanısı genellikle klinik bulgulara eşlik eden transüda vasfında plevral sıvı-nın gösterilmesiyle konulur. Light kriterleri transüda eksü-da ayırımında en sık kullanılan yöntem olmakla birlikte bazı transüdatif sıvıları eksüda olarak sınıflayabilmektedir. Miyositlerden ventrikül gerilimine cevap olarak salınan NT-proBNP'nin son yıllarda kalp yetmezliğine bağlı efüz-yonu diğer efüzyon nedenlerinden ayırımını inceleyen araştırmalar yayınlanmıştır. Bu çalışmalara göre plevral NT-proBNP yüksek tanı değeri ile kardiyak orijinli sıvıları ayırt edebilmektedir. Serum ve plevral sıvı için optimal sınır değeri 1000 ile 1500 ng/ml arasında değişmektedir. Özellikle Light kriterlerince eksüda saptanan kardiyak nedenli efüzyonları NT-proBNP başarı ile tespit etmektedir. Ayrıca serum ile plevral sıvı NT-proBNP değerleri yüksek korelasyon göstermektedir. Mevcut bulgulara göre NT-proBNP, Light kriterleri ile eksüda saptanan ancak klinik olarak kalp yetmezliği düşünülen kalp yetmezliğine bağlı efüzyonlarda kullanım alanı bulabilir. Ayrıca minimal efüzyonu olan, torasentezin riskli olabileceği kalp yetmezliğinden şüphelenilen hastalarda serum NT-proBNP faydalı olabilir. Anahtar kelimeler: Kalp yetmezliği natriüretik peptidler, plevral efüzyon AbstractThe diagnosis of pleural effusion due to heart failure is usually based on showing transudate fluid accompanied by clinical findings. Although applying Light's criteria is the most common method for discriminating transudate and exudate fluids, it may lead to a misclassification of transudate fluid as exudate in some cases. Recent studies have shown the differentiation of pleural effusions due to heart failure from other causes by NT-proBNP, which is secreted from ventricular myocytes in response to tension in the ventricles. Pleural fluid due to heart failure can be determined with high diagnostic yield by NT-proBNP according to these studies. The optimal cut-off value of serum and pleural fluid ranged from 1000 to 1500 ng/ml. NT-proBNP was successfully detected in pleural fluids due to heart failure which were misclassified by Light's criteria as exudate. In addition, serum and pleural fluid NT-proBNP levels show a high correlation. According to the present findings, NT-proBNP can be a useful tool to diagnose pleural effusions due to clinically suspicious heart failure in patients diagnosed by Light's criteria as exudate. Serum NT-proBNP can also prevent risky thoracentesis in patients with suspected heart failure with minimal effusion.Key words: Heart failure, natriuretic peptides, pleural effusion Giriş Birçok sistemik ve lokal hastalığın komplikasyonu olan plevral efüzyon sık görülmektedir. İç hastalıkları kliniklerine başvuran hastaların %4'ünü plevral efüz-yon oluşturmaktadır (1, 2). Bir seride, iç hastalıkları kliniklerinde değerlendirilmesi gereken hastalığı bulunanların %10'unda plevral efüzyon geliştiği, bunların da %30-40'ında nedenin kalp yetersizliği olduğu belirtilmektedir (3, 4). Kalp yetmezliğine bağlı plevral efüz-yonun ta...

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“…There are extensive studies in the medical literature that document the excellent ability of both BNP and NTproBNP to diagnose HF [9][10][11]. In the multinational Breathing Not Properly study, 1586 patients with acute shortness of breath were examined [12].…”

Section: Natriuretic Peptides and Heart Failurementioning

confidence: 99%