B lymphocyte stimulator −817C&gt;T promoter polymorphism and the predisposition for the development of deep infiltrating endometriosis

Graaff, Aisha A. de; Dunselman, G.A.J.; Delvoux, Bert; Kaam, K. J. van; Smits, Luc; Romano, Andrea

doi:10.1016/j.fertnstert.2009.10.041

Cited by 12 publications

(7 citation statements)

References 12 publications

(14 reference statements)

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“…Recently, de Graaff et al. [9] observed an association between deep infiltrating endometriosis and BLyS ‐817C/T polymorphism. Their findings suggested that heterozygous patients for the BLyS ‐817C>T polymorphism are at less risk of the development of severe endometriosis compared with homozygous patients for the common (‐817C) or the polymorphic (‐817 T) allele, once both C/C and T/T genotypes were more prevalent in patients with deep infiltrating endometriosis as compared with the control group.…”

Section: Introductionmentioning

confidence: 99%

Promoter ‐817C>T Variant of B Lymphocyte Stimulator Gene (BLyS) and Susceptibility to Endometriosis‐Related Infertility and Idiopathic Infertility in Brazilian Population

et al. 2011

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Many theories have been proposed to explain the development of endometriosis, and recently, autoimmune aetiology has been suggested. Besides, it is well known that endometriosis, especially the advanced disease, may impair fertility. B lymphocyte stimulator (BLyS) is a cytokine produced by macrophages and is necessary for normal B cell development. One of the most studied polymorphisms is the ‐817C/T in the promoter region of the gene. We aimed to assess the association between endometriosis‐related infertility and idiopathic infertility and the BLyS ‐817C/T polymorphism in a Brazilian population. We performed a case–control study comprising 165 infertile women with endometriosis, 83 with idiopathic infertility and 145 fertile and assessed the association with BLys ‐817C/T polymorphism. BLyS ‐817C/T polymorphism was detected using TaqMan PCR. The results were analysed statistically, and a P‐value < 0.05 was considered significant. The results disclosed similar genotype and allelic frequencies between endometriosis‐related infertility (P = 0.225) and control group, regardless of the disease stage (P = 0.213 and P = 0.462, respectively). However, a statistically significant difference was observed regarding idiopathic infertile group (P = 0.048) compared with controls. Considering the dominant and recessive inheritance models, no significant differences in both endometriosis and idiopathic infertility group were found. The genotype frequencies were in Hardy–Weinberg equilibrium in all studied groups. The results point to a possible association between BLyS ‐817C/T polymorphism and idiopathic infertility in Brazilian population.

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Section: Introductionmentioning

confidence: 99%

Promoter ‐817C>T Variant of B Lymphocyte Stimulator Gene (BLyS) and Susceptibility to Endometriosis‐Related Infertility and Idiopathic Infertility in Brazilian Population

et al. 2011

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“…Based on these observations, Graaff et al (2010) [125] assessed the prevalence of the BLyS -817C/T polymorphic variant among women with either deep infiltrating endometriosis or adenomyosis compared with a group of gynecologic patients without endometriosis and a group of healthy women. The study suggested a relation between BLyS Ϫ817C Ͼ T polymorphism heterozygosity and a decreased risk of the development of deep infiltrating endometriosis.…”

Section: Blys-tumor Necrosis Factor (Ligand) Superfamily Member 13b mentioning

confidence: 99%

“…The genotype frequencies were in Hardy-Weinberg equilibrium in all groups studied. Once, in a study by Graaff et al (2010) [125], the genotype frequencies of patients with deep infiltrating endometriosis were not in Hardy-Weinberg equilibrium, and the authors did not mention the reproductive status of their patients. Christofolini et al (2011) [126] supposed that, maybe, in the Graaff et al sample, some patients presented with infertility associated with endometriosis.…”

Section: Blys-tumor Necrosis Factor (Ligand) Superfamily Member 13b mentioning

confidence: 99%

The possible role of genetic variants in autoimmune-related genes in the development of endometriosis

et al. 2012

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“…Una de las más claras pruebas de que se trata de una entidad diferente proviene del origen mismo. Se han demostrado diferencias en la expresión de genes entre pacientes con endometriosis infiltrativa profunda y pacientes con lesiones peritoneales u ováricas (14,15).…”

Section: Diferente Comportamiento Bioquímico Celular Y Molecularunclassified

¿Por qué la endometriosis infiltrativa profunda debe ser considerada una entidad diferente a la endometriosis peritoneal?

Ríos-Posada¹

2012

Rev. Colomb. Obstet. Ginecol.

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El presente artículo de revisión recopila, expresa, demuestra y analiza información científica que permite concluir con claridad que la endometriosis infiltrativa profunda es una entidad nosológica diferente en múltiples aspectos fisiopatológicos, diagnósticos y terapéuticos a la endometriosis peritoneal.Fue presentado, discutido y avalado por el Consenso Colombiano de Expertos en Endometriosis llevado a cabo dentro del marco del XXVIII Congreso Colombiano de Obstetricia y Ginecología en mayo de 2012.Pretende ser un documento de consulta y de soporte bibliográfico y legal que brinde claridad a los actores del sistema de salud colombiano y al público en general sobre las obvias diferencias que existen entre las dos enfermedades.

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B lymphocyte stimulator −817C>T promoter polymorphism and the predisposition for the development of deep infiltrating endometriosis

Cited by 12 publications

References 12 publications

Promoter ‐817C>T Variant of B Lymphocyte Stimulator Gene (BLyS) and Susceptibility to Endometriosis‐Related Infertility and Idiopathic Infertility in Brazilian Population

Promoter ‐817C>T Variant of B Lymphocyte Stimulator Gene (BLyS) and Susceptibility to Endometriosis‐Related Infertility and Idiopathic Infertility in Brazilian Population

The possible role of genetic variants in autoimmune-related genes in the development of endometriosis

¿Por qué la endometriosis infiltrativa profunda debe ser considerada una entidad diferente a la endometriosis peritoneal?

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