<b><i>Helicobacter pylori</i></b> immunoproteomes in case reports of rosacea and chronic urticaria

Mini, Roberta; Figura, Natale; D’Ambrosio, Chiara; Braconi, Daniela; Bernardini, Giulia; Simplicio, F. Di; Lenzi, C.; Nuti, Ranuccio; Trabalzini, Lorenza; Martelli, Paola; Bovalini, Lucia; Scaloni, Andrea; Santucci, Annalisa

doi:10.1002/pmic.200401094

Cited by 34 publications

(29 citation statements)

References 64 publications

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“…Mini et al [37] berichteten spezifische IgA-und IgE-vermittelte Immunantworten gegen antioxidative bakterielle Proteine bei Patienten mit chronischer Urtikaria und Helicobacter-Infektion, nicht aber bei Helicobacter-Infektion ohne Urtikaria.…”

Section: E Bei Der Chronischen Urtikaria Haben Mehrere Studien Spezifunclassified

Infektfokus und chronische spontane Urtikaria

et al. 2010

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Urticaria represents a common skin reaction pattern that can be induced by different factors. Triggering by infections has been discussed for many years but the exact role and mechanism of mast cell activation by infectious processes is unclear. In acute spontaneous urticaria, there is no doubt about a causal relationship to infections and all chronic urticaria must start as acute. Remission of annoying spontaneous chronic urticaria has been reported after successful treatment of persistent infections. Summarizing available studies evaluating the course after proven Helicobacter eradication demonstrates a statistically significant benefit compared to not-eradicated or Helicobacter-negative patients. The licensed treatment with a standard dose of H1-antihistamines is not effective in a significant number of patients and infections can be easily treated. Therefore, appropriate diagnostic procedures should be included in the routine work-up, especially the search for Helicobacter pylori.

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Section: E Bei Der Chronischen Urtikaria Haben Mehrere Studien Spezifunclassified

Infektfokus und chronische spontane Urtikaria

et al. 2010

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“…In fact, few studies have reported the presence of cag PAI proteins at the membrane level or in culture supernatants (28,60). Indeed, these proteins are obviously produced in amounts that are below the detection limit of the applied method and are rather detected by immunoblotting (48,129,140,141). Moreover, it was suggested that some proteins of the type IV secretion system contributing to virulence may not be expressed under in vitro culture conditions; rather their expression may be dependent on in vivo stimuli such as bacterium-host cell contact (160,161).…”

Section: Discussionmentioning

confidence: 99%

“…Both of these proteins were reported to be among the 20 most abundant proteins in H. pylori and to be antigenic (48,79,119,128,129). NapA was found in the cytoplasm (120) and in the membrane (69) and is also secreted (60).…”

Section: Cytosolic Protein Complexesmentioning

confidence: 99%

Complexomics Study of Two Helicobacter pylori Strains of Two Pathological Origins

Bernarde

Lehours

Lasserre

et al. 2010

Molecular & Cellular Proteomics

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Helicobacter pylori infection plays a causal role in the development of gastric mucosa-associated lymphoid tissue (MALT) lymphoma (LG-MALT) and duodenal ulcer (DU). Although many virulence factors have been associated with DU, many questions remain unanswered regarding the evolution of the infection toward this exceptional event, LG-MALT. The present study describes and compares the complexome of two H. pylori strains, strain J99 associated with DU and strain B38 associated with LG-MALT, using the two-dimensional blue native/SDS-PAGE method. It was possible to identify 90 different complexes (49 and 41 in the B38 and J99 strains, respectively); 12 of these complexes were common to both strains (seven and five in the membrane and cytoplasm, respectively), reflecting the variability of H. pylori strains. The 44 membrane complexes included numerous outer membrane proteins, such as the major adhesins BabA and SabA retrieved from a complex in the B38 strain, and also proteins from the hor family rarely studied. BabA and BabB adhesins were found to interact independently with HopM/N in the B38 and J99 strains, respectively. The 46 cytosolic complexes essentially comprised proteins involved in H. pylori physiology. Some orphan proteins were retrieved from heterooligomeric complexes, and a function could be proposed for a number of them via the identification of their partners, such as JHP0119, which may be involved in the flagellar function. Overall, this study gave new insights into the membrane and cytoplasm structure, and those which could help in the design of molecules for vaccine and/or antimicrobial agent development are highlighted. Molecular & Cellular Proteomics 9:2796 -2826, 2010.

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“…The most recent of these have focused on possible pathogenetic mechanisms, and specifically, the postulation that H. pylori infection could induce the production of pathogenetic autoantibodies associated with CIU via molecular mimicry. Such a mechanism might allow for antibody production following H. pylori elimination, thereby explaining the lack of improvement in some CIU patients after antibiotic therapy [47,48]. Whereas Mini et al [48] present a case report in which immunoproteomic analysis supports such an autoantibody-production relationship, Baskan et al [47] found no such association using autologous serum skin testing in a non-random sample of 47 CIU patients.…”

Section: Chronic Idiopathic Urticariamentioning

confidence: 94%

Extragastric diseases associated with Helicobacter pylori infection

Goodman

Joyce²,

Ismond³

2006

Curr Gastroenterol Rep

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This paper critically reviews the current literature on extragastric diseases associated with Helicobacter pylori infection, with an emphasis on methodologic issues that complicate interpretation of study findings. This review reveals common study limitations and overall uncertainty that H. pylori infection plays a role in extragastric diseases, although such a role has not been clearly ruled out for specific diseases of relevance. Evidence suggests that anti-H. pylori therapy may lead to improvement of a few extragastric diseases, in particular, idiopathic thrombocytopenic purpura, iron deficiency anemia, and chronic idiopathic urticaria, but the data from randomized controlled trials are insufficient to confirm this beneficial effect; if the benefit of anti-H. pylori therapy for specific diseases is real, it is not clear if it results from removing H. pylori-specific injurious effects, eliminating some other infectious pathogen, or reducing the total infectious burden.

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Helicobacter pylori immunoproteomes in case reports of rosacea and chronic urticaria

Cited by 34 publications

References 64 publications

Infektfokus und chronische spontane Urtikaria

Infektfokus und chronische spontane Urtikaria

Complexomics Study of Two Helicobacter pylori Strains of Two Pathological Origins

Extragastric diseases associated with Helicobacter pylori infection

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