Chrystelle Lamagna, Yongmei Hu, Anthony L. DeFranco, Clifford A. Lowell
The Lyn tyrosine kinase regulates inhibitory signaling in B and myeloid cells – loss of Lyn results in a lupus-like autoimmune disease with hyperactive B cells and myeloproliferation. We have characterized the relative contribution of Lyn-regulated signaling pathways in B cells specifically to the development of autoimmunity by crossing the novel lynf/f animals with mice carrying the Cre recombinase under the control of the Cd79a promoter, resulting in deletion of Lyn in B cells. The specific deletion of Lyn …
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