2011
DOI: 10.1016/j.vaccine.2010.12.099
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Abstract: The Plasmodium vivax Merozoite Surface Protein-3α (PvMSP-3α) is considered as a potential vaccine candidates. However, the detailed investigations of the type of immune responses induced in naturally exposed populations are necessary. Therefore, we aim to characterize the naturally induced antibody to PvMSP-3α in 282 individuals with different levels of exposure to malaria infections residents in Brazilian Amazon. PvMSP3 specific antibodies (IgA, IgG and IgG subclass) to five recombinant proteins and the epito… Show more

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Cited by 41 publications
(46 citation statements)
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“…The two cross-sectional studies gave opposing results and were not combined (I 2 > 75% and/or P < 0.01). Lima-Junior et al [25] showed around a 60% reduction in the odds of P. vivax infection in IgG responders to PvMSP-3α full-length (MSP-3α FL ), PvMSP-3α NT , PvMSP-3α RI , and around a 35% reduction for PvMSP-3α RII and PvMSP-3α CT compared with non-responders ( Figure 6). Conversely, Stanisic et al [36] showed fold increases of between Figure 5 Forest plot of the association of PvMSP-1 N-terminus IgG responses with Plasmodium vivax outcomes.…”
Section: Cross-sectional Studiesmentioning
confidence: 95%
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“…The two cross-sectional studies gave opposing results and were not combined (I 2 > 75% and/or P < 0.01). Lima-Junior et al [25] showed around a 60% reduction in the odds of P. vivax infection in IgG responders to PvMSP-3α full-length (MSP-3α FL ), PvMSP-3α NT , PvMSP-3α RI , and around a 35% reduction for PvMSP-3α RII and PvMSP-3α CT compared with non-responders ( Figure 6). Conversely, Stanisic et al [36] showed fold increases of between Figure 5 Forest plot of the association of PvMSP-1 N-terminus IgG responses with Plasmodium vivax outcomes.…”
Section: Cross-sectional Studiesmentioning
confidence: 95%
“…The full texts of these 162 studies were examined to determine whether they complied with eligibility criteria: 114 did not meet the inclusion criteria (see Additional file 3), 7 fulfilled the inclusion and quality criteria (Figure 1), and 41 studies potentially met inclusion and quality criteria. The authors of the 41 studies that potentially met inclusion and quality criteria were contacted, yielding a further 11 studies that met inclusion and quality criteria, providing a total of 18 studies that were included in the review [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] (Figure 1). Details of these 18 studies are shown in Table 1.…”
Section: Identification and Description Of Included Studiesmentioning
confidence: 99%
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“…Such initial observations of polymorphism, together with the fact that these proteins are immunogenic (Bitencourt et al, 2013; Lima-Junior et al, 2011, 2012; Mourão et al, 2012), are thought to indicate that the msp3 family has an important function in the RBC invasion process, possibly through a role in immune evasion (Jiang et al 2013). …”
Section: Introductionmentioning
confidence: 99%
“…We previously used a similar method to compare sera from mice immunized with one PspA variant as a recombinant protein and as a DNA vaccine (34). This technique has also been used successfully to screen epitopes of antigens from other pathogens (35,36). The present study tested sera from mice immunized with several variants of PspA and PspC3 to identify the most immunogenic epitopes.…”
mentioning
confidence: 99%