Aβ amyloid, cognition, andAPOEgenotype in healthy older adults

Abstract

In APOE ε 4 carriers, there is a moderate negative relationship between cerebral Aβ and episodic memory. This suggests that increased cerebral Aβ may signify the onset of preclinical AD, especially in healthy older adults who are genetically at risk for AD.

Autobiographical narratives relate to Alzheimer's disease biomarkers in older adults

“…Our findings align with studies showing verbal memory dysfunction in amyloid positive elderly without dementia (Pike et al, 2007;Rentz et al, 2011;Lim et al, 2014). This relationship between PSM and neocortical amyloid deposition was not changed by controlling for age, gray matter volume, and APOE ε4 carrier status, suggesting a slight divergence from some studies showing a moderating effect of APOE ε4 (Kantarci et al, 2012;Lim et al, 2013).…”

APOE ε4 moderates amyloid-related memory decline in preclinical Alzheimer's disease

“…Although in vitro studies suggest that 34 is directly and indirectly related to amyloidosis (Jiang et al, 2008;Liu et al, 2013), clinical evidence for this association in humans remains equivocal. Cross-sectional studies with appropriate sample sizes (e.g., n > 200) report no cognitive impairment in Abþ individuals irrespective of whether they carry 34 (Doraiswamy et al, 2012;Lim et al, 2013aLim et al, , 2013bLim et al, , 2013c. However, potential interactions between Ab and 34 carriage were suggested by observations in 2 different cohorts that associations between Ab levels and memory performance were evident only in 34 carriers (Kantarci et al, 2012;Lim et al, 2013aLim et al, , 2013bLim et al, , 2013c.…”

“…Cross-sectional studies with appropriate sample sizes (e.g., n > 200) report no cognitive impairment in Abþ individuals irrespective of whether they carry 34 (Doraiswamy et al, 2012;Lim et al, 2013aLim et al, , 2013bLim et al, , 2013c. However, potential interactions between Ab and 34 carriage were suggested by observations in 2 different cohorts that associations between Ab levels and memory performance were evident only in 34 carriers (Kantarci et al, 2012;Lim et al, 2013aLim et al, , 2013bLim et al, , 2013c. Initial prospective studies in preclinical AD showed that rates of Ab-related memory decline were not increased when 34 carrier status was added to predictive models (Doraiswamy et al, 2012;Lim et al, 2012;Roe et al, 2013), suggesting that the risk for memory decline and AD posed by 34 carrier status was a consequence of 34 carriage accelerating Ab accumulation.…”

Стан Когнітивних Функцій У Пацієнтів Із Фібриляцією Передсердь Та Різним Генотипом Аполіпопротеїну Е

“…Було обстежено 158 здорових літ-ніх особи з проведенням ПЕТ з PiB (пітсбурзьким лігандом β-амілоїду), генетичного тестування і комплексного нейропсихологічного обстеження. Було показано, що у носіїв АРОЕ4 існує сильний негативний кореляційний взаємозв'язок між ко-роткочасною вербальною пам'яттю і накопичен-ням амілоїдного білка [19]. Крім того, у носіїв АРОЕ4 атрофія гіпокампа з перебігом хвороби роз-вивається швидше.…”