Azomethine-functionalized task-specific ionic liquid for diversion of toxic metal ions in the aqueous environment into pharmacological nominates

El-Sayed, W.N.; Alkabli, J.; Althumayri, Khalid; Elshaarawy, Reda F.M.; Ismail, Lamia A.

doi:10.1016/j.molliq.2020.114525

Cited by 15 publications

(7 citation statements)

References 54 publications

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“…Imidazolium salts 1h , 1i , 1j , and 1k were synthesized through the procedures described in the literature. [ 50–53 ]…”

Section: Methodsmentioning

confidence: 99%

“…Imidazolium salts 1h, 1i, 1j, and 1k were synthesized through the procedures described in the literature. [50][51][52][53] 1 The hCA isoenzymes were purified by Sepharose-4B-L-tyrosinesulfanilamide affinity techniques. [69] After affinity chromatography, the purity of both isoenzymes was determined by SDS-PAGE according to the previous study.…”

Section: X-ray Crystallographymentioning

confidence: 99%

“…[9,21] In addition, imidazolium salts displayed a broad range of biological properties including antimicrobial, antitumor, and antifungal activities. [22][23][24] Recently, these salt molecules were reported to be effective inhibitors of some metabolic enzymes. For example, it was reported that some coumarin substituted imidazolium and benzimidazolium salts demonstrated an important inhibitory effect on the paraoxonase activity.…”

Section: Introductionmentioning

confidence: 99%

“…To complete the series of imidazolium salts with phthalimide groups, the salts 1h-k were synthesized again for this study as reported previously. [50][51][52][53]…”

Section: Introductionmentioning

confidence: 99%

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Phthalimide‐tethered imidazolium salts: Synthesis, characterization, enzyme inhibitory properties, and in silico studies

Yiğit

Demir

Celepci

et al. 2022

Archiv der Pharmazie

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A series of new imidazolium salts were prepared in good yield by the reaction between 1-alkylimidazole and a variety of alkyl halides. The structures of the compounds were identified by FT-IR, 1 H NMR, and 13 C NMR spectroscopy, elemental analysis, and mass spectrometry. The crystal structure of 1b was determined by the single-crystal X-ray diffraction method. The phthalimidetethered imidazolium salts exhibited inhibition abilities toward acetylcholinesterase (AChE) and human carbonic anhydrases (hCAs) I and II, with K i values in the range of 24.63 ± 3.45 to 305.51 ± 35.98 nM for AChE, 33.56 ± 3.71 to 218.01 ± 25.21 nM for hCA I and 17.75 ± 0.96 to 308.67 ± 13.73 nM for hCA II. The results showed that the new imidazolium salts can play a key role in the treatment of Alzheimer's disease, epilepsy, glaucoma, and leukemia, which is related to their inhibition abilities of hCA I, hCA II, and AChE. Molecular docking and in silico absorption, distribution, metabolism, excretion and toxicity studies were used to look into how the imidazolium salts interacted with the specific protein targets. To better visualize and understand the binding positions and the influence of the imidazolium salts on hCA I, hCA II, and AChE conformations, each one was subjected to molecular docking simulations.

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“…Imidazolium salts 1h , 1i , 1j , and 1k were synthesized through the procedures described in the literature. [ 50–53 ]…”

Section: Methodsmentioning

confidence: 99%

Section: X-ray Crystallographymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…To complete the series of imidazolium salts with phthalimide groups, the salts 1h-k were synthesized again for this study as reported previously. [50][51][52][53]…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Phthalimide‐tethered imidazolium salts: Synthesis, characterization, enzyme inhibitory properties, and in silico studies

Yiğit

Demir

Celepci

et al. 2022

Archiv der Pharmazie

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“…The amazing physical and chemical properties of ionic liquids (ILs), such as excellent thermal and chemical stability, non-ammability, non-volatile, amphiphilic nature, reusability, and electric conductivity, 8 make them promising candidates for many applications. 9 In this scenario, they have been efficiently used as solvents and/or catalysts for organic reactions, 10,11 fabrication of nanomaterials, 12 electrochemical sensors and biosensors, 13 optical chemosensors, 14,15 pH nano-uorosensing, 16 scavenging of pollutants from aqueous effluents, 17,18 etc. 9 Furthermore, ILs have been implicated in a variety of biological and pharmaceutical applications due to their low toxicity toward many biological targets and their exceptional pharmacological capabilities.…”

Section: Introductionmentioning

confidence: 99%

Fine-tuning of the pharmacological potential of novel thiazolium ionic liquids by anion alteration

et al. 2022

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Synthesis and Characterization of New Lutidinium Ionic Liquid‐Supported Vanadylsalicylaldoxime Complex for Catalytic Application in Epoxidation Reaction

Elshaarawy

Gawad

Hassan

et al. 2023

Chemistry & Biodiversity

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A new chelating task-specific ionic liquid (TSIL), lutidinium-based salicylaldoxime (LSOH), and its square pyramidal vanadyl(II) complex (VO(LSO) 2 ) have been successfully synthesized and structurally characterized using elemental (CHN), spectral, and thermal analyses. The catalytic activity of the lutidinium-salicylaldoxime complex (VO(LSO) 2 ) in the alkene epoxidation reactions was studied under various reaction conditions, such as solvent effect, alkene/oxidant molar ratio, pH, reaction temperature, reaction time, and the catalyst dose. The results demonstrated that the CHCl 3 solvent, 1 : 3 of the cyclohexene/H 2 O 2 ratio, pH 8, temperature of 340 K, and catalyst dose of 0.012 mmol are assigned as the optimum conditions for achieving maximum catalytic activity for VO(LSO) 2 . Moreover, the VO(LSO) 2 complex has the potential for application in the effective and selective epoxidation of alkenes. Notably, under optimal VO(LSO) 2 conditions, cyclic alkenes convert more efficiently to their corresponding epoxides than linear alkenes.

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Azomethine-functionalized task-specific ionic liquid for diversion of toxic metal ions in the aqueous environment into pharmacological nominates

Cited by 15 publications

References 54 publications

Phthalimide‐tethered imidazolium salts: Synthesis, characterization, enzyme inhibitory properties, and in silico studies

Phthalimide‐tethered imidazolium salts: Synthesis, characterization, enzyme inhibitory properties, and in silico studies

Fine-tuning of the pharmacological potential of novel thiazolium ionic liquids by anion alteration

Synthesis and Characterization of New Lutidinium Ionic Liquid‐Supported Vanadylsalicylaldoxime Complex for Catalytic Application in Epoxidation Reaction

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