Azomethine based nano-chemicals: Development, in vitro and in vivo fungicidal evaluation against Sclerotium rolfsii , Rhizoctonia bataticola and Rhizoctonia solani

Mondal, Prithusayak; Kumar, Rajesh; Gogoi, Robin

doi:10.1016/j.bioorg.2016.12.006

Cited by 29 publications

(12 citation statements)

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“…The best antifungal performance was observed with miconazole nitrate. Better antifungal performance of nanoazomethines 13 than their conventional ones has also been reported under pot culture conditions for the management of R. solani, R. bataticola, and S. rolfsii. Saini and coworkers 29,30 developed a pyridalyl nanosuspension having insecticidal activity against larvae of Helicoverpa armigera at an LC 50 value of 40 μg/mL.…”

Section: ■ Results and Discussionmentioning

confidence: 91%

“…A number of nanochemicals 13−18 have been reported in the literature 29−33 due to their impact on different bioactivities, plant physiology, soil health, and environment. 60−70 A comparative in vitro antifungal study of the synthesized nanoazomethines 13 with their conventional counterparts against agriculturally important fungal pathogens, R. solani, R. bataticola, and S. rolfsii, also revealed the augmentation in antifungal activity by using nanoproducts. Gogoi et al demonstrated superior effectiveness of nanosulfur 62 in comparison with commercially available formulations, in controlling Erysiphe cichoracearum of okra (Abelmoschus esculentus Moench).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Nanoformulations are used extensively in the fields of pharmacy and medicine . However, their applications in the field of pest management − are just emerging as a newly developed field. In order to achieve improved performance compared to the existing active ingredients, most of the nanopesticides and nanofertilizers proposed to date involve reformulation of registered active ingredients. − Several consumer products involve incorporation of nanomaterials because of their unique physicochemical properties that emerge as a result of nanorange dimensions.…”

Section: Introductionmentioning

confidence: 99%

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Preparation of Nanofungicides Based on Imidazole Drugs and Their Antifungal Evaluation

Tippannanavar

Verma

Kumar

et al. 2020

J. Agric. Food Chem.

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In spite of modern crop protection measures, the overall crop losses due to pests and pathogens are huge. Rhizoctonia solani, Macrophomina phaseolina, Sclerotium rolfsii, and Fusarium oxysporum are one of the most devastating soil-borne fungi and cause numerous plant diseases. Therefore, the present study aimed to systematically design and develop new nanofungicides based on imidazole drugs, clotrimazole, econazole nitrate, and miconazole nitrate, for effective and efficient management of plant diseases. The assessment of these antifungal medicines for their fungicide likeness using Hao’s rule and their enzyme inhibitory potential by molecular docking was helpful in ensuring their utility as antifungal agents in managing phytopathogenic fungi. Nanotechnological strategies were used to develop nanoformulations of test compounds in poly(ethylene glycol) 300 for further augmenting their bioactivity. Transmission electron microscopy studies confirmed the nanosize of the prepared products. Analysis of their in vitro and in vivo antifungal properties revealed their usefulness in controlling the test fungi, R. solani, M. phaseolina, S. rolfsii, and F. oxysporum. Excellent in vitro antifungal activities were displayed by the clotrimazole nanoformulation with a median effective dose (ED50) of 1.18 μg/mL against R. solani, the econazole nitrate nanoformulation with an ED50 of 5.25 μg/mL against S. rolfsii, and the miconazole nitrate nanoformulation with an ED50 of 1.49 and 1.82 μg/mL against M. phaseolina and F. oxysporum. Furthermore, in vivo studies against test fungi demonstrated the antifungal potency of all the nanoformulations with disease incidences ranging from 11.11 to 27.38% in plants treated with nanoformulations of test chemicals as compared to the inoculated control (39.68–72.38%).

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Section: ■ Results and Discussionmentioning

confidence: 91%

Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preparation of Nanofungicides Based on Imidazole Drugs and Their Antifungal Evaluation

Tippannanavar

Verma

Kumar

et al. 2020

J. Agric. Food Chem.

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“…Schiff base derivatives are useful compounds that have many applications. They have been playing vital roles in the pharmaceutical industry as antimicrobials, antidepressants, cytotoxics, analgesics, antileischmanials, anticonvulsants and fungicides and as anti‐inflammatory and anticancer agents . In coordination chemistry, Schiff bases constitute privileged ligands that can form stable complexes with transition metals .…”

Section: Introductionmentioning

confidence: 99%

New copper(II) and zinc(II) complexes based on azo Schiff base ligand: Synthesis, crystal structure, photoisomerization study and antibacterial activity

Slassi

El‐Ghayoury

Aarjane

et al. 2020

Applied Organom Chemis

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Newly synthesized mononuclear copper(II) and zinc(II) complexes containing an azo Schiff base ligand (L), prepared by condensation of 2‐hydroxy‐5‐(o‐tolyldiazenyl)benzaldehyde and propylamine, were obtained and then characterized using infrared and NMR spectroscopies, mass spectrometry and X‐ray diffraction. Ligand L behaves as a bidentate chelate by coordinating through deprotonated phenolic oxygen and azomethine nitrogen. The copper and zinc complexes crystallize in triclinic and orthorhombic systems, respectively, with space groups P−1 and Pca21. In these complexes, the Cu(II) ion is in a square planar geometry while the Zn(II) ion is in a distorted tetrahedral environment. The photochemical behaviors of ligand L, [Cu(L)2] and [Zn(L)2] were investigated. The azo group in L underwent reversible trans–cis isomerization under UV and visible irradiation. This process was inhibited for the complexes. In addition, ligand L and its copper and zinc complexes were assessed for their in vitro antibacterial activities against four pathogenic strains.

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“…The prolific growth of S. rolfsii , as well as its ability to produce numerous sclerotia that can survive in the soil for years, hamper our ability to control the fungus in the field. Various methods used to control S. rolfsii 2 include application of fungicides, alone or as a part of integrated management strategies . A well‐known biocontrol agent comprises saprophytic soil fungi from the genus Trichoderma (see reviews by Papavizas and Whipps), which control S. rolfsii in various crops .…”

Section: Introductionmentioning

confidence: 99%

trans‐2‐Octenal, a single compound of a fungal origin, controls Sclerotium rolfsii, both in vitro and in soil

Liarzi

Benichis

Gamliel

et al. 2020

Pest Management Science

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BACKGROUND: Sclerotium rolfsii is a soil-borne phytopathogenic fungus that causes diseases in economically important crops. Eradication of the fungus is hampered by its wide range of hosts, as well as its capacity to form sclerotia. Recently, we have shown that the endophytic fungus Daldinia cf. concentrica emits biologically active volatile organic compounds (VOCs); we also demonstrated that one VOC, trans-2-octenal, was the most effective against various phytopathogenic fungi. Thus, the aim of this study was to examine the potential of this compound to control hyphae and sclerotia of S. rolfsii, both in vitro and in soil. RESULTS:We found that in vitro exposure of S. rolfsii mycelium to trans-2-octenal in air fully inhibits and kills the fungus. Elimination of sclerotia viability occurred at the same concentration, but direct contact between the sclerotia and the compound was needed. trans-2-Octenal also affected the viability of both hyphae and sclerotia of S. rolfsii in small pots containing loam soil.CONCLUSION: We suggest the use of trans-2-octenal as a novel compound to control S. rolfsii.

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Azomethine based nano-chemicals: Development, in vitro and in vivo fungicidal evaluation against Sclerotium rolfsii , Rhizoctonia bataticola and Rhizoctonia solani

Cited by 29 publications

References 31 publications

Preparation of Nanofungicides Based on Imidazole Drugs and Their Antifungal Evaluation

Preparation of Nanofungicides Based on Imidazole Drugs and Their Antifungal Evaluation

New copper(II) and zinc(II) complexes based on azo Schiff base ligand: Synthesis, crystal structure, photoisomerization study and antibacterial activity

trans‐2‐Octenal, a single compound of a fungal origin, controls Sclerotium rolfsii, both in vitro and in soil

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