Azimuthally oscillating membrane emulsification for controlled droplet production

Silva, Pedro Santos; Dragosavac, Marijana M.; Vladisavljević, Goran T.; Bandulasena, Hemaka C.H.; Holdich, Richard; Stillwell, Mike; Williams, Bruce

doi:10.1002/aic.14894

Cited by 26 publications

(27 citation statements)

References 19 publications

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“…Microfabricated pore arrays are similar to massively parallel T junctions, through which one fluid may be introduced into another at an overall much higher flow rate than is possible in individual channels [29]. The mixing rate can 4 be enhanced by providing a controlled shear at the membrane surface using cross flow [30], stirring [23], flow pulsations [31], radially or axially oscillating membrane tube [32,33], and rotating membrane [24]. However, the role of different pore arrangements, pore shapes and fabrication methods on the performance of microfabricated membrane in micromixing process…”

Section: Graphical Abstractmentioning

confidence: 99%

Formation of size-tuneable biodegradable polymeric nanoparticles by solvent displacement method using micro-engineered membranes fabricated by laser drilling and electroforming

Othman

Vladisavljević

Shahmohamadi

et al. 2016

Chemical Engineering Journal

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Section: Graphical Abstractmentioning

confidence: 99%

Formation of size-tuneable biodegradable polymeric nanoparticles by solvent displacement method using micro-engineered membranes fabricated by laser drilling and electroforming

Othman

Vladisavljević

Shahmohamadi

et al. 2016

Chemical Engineering Journal

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“…In an oscillating ME system, tubular membrane can oscillate tangentially clockwise and counter-clockwise (Silva et al 2015) or radially upward and downward (Holdich et al, 2010), with frequencies from 10 to 90 Hz.…”

Section: Emulsification Using Microengineered Membranesmentioning

confidence: 99%

“…cross-flow), shear stress is uniformly distributed over the membrane surface and localised to the membrane wall rather than the entire bulk volume of the fluid. A Computational Fluid Dynamics (CFD) analysis has shown that in an azimuthally oscillating membrane emulsification system, shear rate becomes negligible at radial distances from the membrane surface of just 0.5 mm although the shear rate could be 1400 s −1 at the membrane surface (Silva et al, 2015). Due to controlled localised shear and geometrically-mediated drop formation, the droplet size can be precisely controlled over a wide range and a narrow droplet size distribution can be achieved.…”

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confidence: 99%

Structured microparticles with tailored properties produced by membrane emulsification

Vladisavljević

2015

Advances in Colloid and Interface Science

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This paper provides an overview of membrane emulsification routes for fabrication of structured microparticles with tailored properties for specific applications. Direct (bottom-up) and premix (top-down) membrane emulsification processes are discussed including operational, formulation and membrane factors that control the droplet size and droplet generation regimes. A special emphasis was put on different methods of controlled shear generation on membrane surface, such as cross flow on the membrane surface, swirl flow, forward and backward flow pulsations in the continuous phase and membrane oscillations and rotations. Droplets produced by membrane emulsification can be used for synthesis of particles with versatile morphology (solid and hollow, matrix and core/shell, spherical and non-spherical, porous and coherent, composite and homogeneous), which can be surface functionalised and coated or loaded with macromolecules, nanoparticles, quantum dots, drugs, phase change materials and high molecular weight gases to achieve controlled/targeted drug release and impart special optical, chemical, electrical, acoustic, thermal and magnetic properties. The template emulsions including metal-in-oil, solid-in-oil-in-water, oil-in-oil, multilayer, and Pickering emulsions can be produced with high encapsulation efficiency of encapsulated materials and narrow size distribution and transformed into structured particles using a variety of different processes, such as polymerisation (suspension, mini-emulsion, interfacial and in-situ), ionic gelation, chemical crosslinking, melt solidification, internal phase separation, layer-by-layer electrostatic deposition, particle self-assembly, complex coacervation, spray drying, sol-gel processing, and molecular imprinting. Particles fabricated from droplets produced by membrane emulsification include nanoclusters, colloidosomes, carbon aerogel particles, nanoshells, polymeric (molecularly imprinted, hypercrosslinked, Janus and core/shell) particles, solder metal powders and inorganic particles. Membrane 2 emulsification devices operate under constant temperature due to low shear rates on the membrane surface, which range from (1−10) × 10 3 s −1 in a direct process to (1−10) × 10 4 s −1 in a premix process.Keywords: Membrane Emulsification; Polymeric microsphere; Microgel; Janus Particle; Core/Shell Particle, Colloidosome. Membrane emulsificationMembrane emulsification (ME) involves preparation of emulsions by pressing a pure dispersed phase or pre-emulsified mixture of the dispersed and continuous phase through a microporous membrane under controlled injection rate and shear conditions. In direct membrane emulsification (DME), one liquid (a dispersed phase) is injected through a microporous membrane into another immiscible liquid (the continuous phase) (Nakashima et al., 1991;, which leads to the formation of droplets at the membrane/continuous phase interface ( Figure 1a). In premix membrane emulsification (PME) (Figure 1b), a pre-emulsion is pressed through the membrane (...

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“…Previously in [1] a novel membrane emulsification device was presented which operates continuously. In [1] a throughput of 1 L h -1 was tested using a 5 µm pore size membrane with an interpore distance of 200 µm.…”

Section: Introductionmentioning

confidence: 99%

“…In [1] a throughput of 1 L h -1 was tested using a 5 µm pore size membrane with an interpore distance of 200 µm. Droplets generated at some conditions were below 50 µm which suggests decreasing the interpore distance by at least three times will still avoid the contact of drops during their growth and detachment.…”

Section: Introductionmentioning

confidence: 99%

Membrane emulsification: Formation of water in oil emulsions using a hydrophilic membrane

Silva

Starov

Holdich

2017

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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It is shown that formation of water based droplets in an immiscible (i.e. oil) continuous phase can be achieved using a hydrophilic porous metal membrane without prior hydrophobic treatment of the membrane surface. This avoids the need for "health and safety approval" of typical hydrophobic treatments for the membrane, which often use chemicals incompatible with pharma or food applications. To investigate this, wetting experiments were carried out:sessile droplets were used to determine static contact angles and a rotating drum system was used to determine contact angles under dynamic conditions. In the latter case the three-phase contact line was observed between the rotating drum, water and the continuous phase used in the emulsification process; a surfactant was present in the continuous phase which, in this process, has a double function: to assist the wetting of the membrane by the continuous phase, and not the disperse phase, and to stabilize the droplets formed at the surface of the porous membrane during membrane emulsification. KeywordsMembrane surface, hydrophilic, water in oil emulsion, polyvinyl alcohol (PVA), droplets and contact angle 2

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Azimuthally oscillating membrane emulsification for controlled droplet production

Cited by 26 publications

References 19 publications

Formation of size-tuneable biodegradable polymeric nanoparticles by solvent displacement method using micro-engineered membranes fabricated by laser drilling and electroforming

Formation of size-tuneable biodegradable polymeric nanoparticles by solvent displacement method using micro-engineered membranes fabricated by laser drilling and electroforming

Structured microparticles with tailored properties produced by membrane emulsification

Membrane emulsification: Formation of water in oil emulsions using a hydrophilic membrane

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