Axonal Polyneuropathy After Acute Dimethylamine Borane Intoxication

Dimethylamine Borane Neurotoxicity

“…The data were further supported by sural nerve biopsy and cutaneous nerve biopsy studies (Kuo et al in press). Our serial nerve conduction studies also confirmed axonal polyneuropathy, particularly in the motor nerves.…”

“…Our time course of DMAB-induced polyneuropathy indicated an acute axonal polyneuropathy (Kuo et al, in press). However, Tsan et al (2005) misdiagnosed the patient as having a delayed polyneuropathy, which may be wrong, because the time course was different from the so-called “delayed polyneuropathy” induced by organophosphate intoxication (Senanyake and Karalliedde 1987).…”

Dimethylamine Borane Neurotoxicity

“…The data were further supported by sural nerve biopsy and cutaneous nerve biopsy studies (Kuo et al in press). Our serial nerve conduction studies also confirmed axonal polyneuropathy, particularly in the motor nerves.…”

“…Our time course of DMAB-induced polyneuropathy indicated an acute axonal polyneuropathy (Kuo et al, in press). However, Tsan et al (2005) misdiagnosed the patient as having a delayed polyneuropathy, which may be wrong, because the time course was different from the so-called “delayed polyneuropathy” induced by organophosphate intoxication (Senanyake and Karalliedde 1987).…”

Neurotoxicity due to dimethylamine borane poisoning via skin absorption: a case report

“…Despite nutritional neurotherapy treatment for more than 3 months, motor nerve injury in the patient's lower limbs showed no notable amelioration. Kuo et al [6] conducted a follow-up with the patient who was reported by Tsan et al [1] , indicated that muscle strength and sensory functions in the feet were still abnormal one year after the exposure. Therefore, persistent polyneuropathy is one of the most important concerns in DMAB poisoning.…”

“…[1,4] Isolated reports indicated that DMAB exposure causes acute cerebellar oedema and peripheral neuropathy. [1,5,6] Herein, we report a case of DMAB poisoning via dermal absorption in which the central and peripheral nervous systems were the primary sites of toxic injury. We highlight the use of brain magnetic resonance imaging (MRI) and electromyography (EMG) for evaluation after exposure.…”

Current data regarding the structure-toxicity relationship of boron-containing compounds

“…Among others, the toxicology data for sodium borate related to disruption on reproductive effects, and general manifestations as irritability, disturbed sleeping, vomiting, diarrhea, or anemia; the adverse effects of BCCs used in chemotherapy (v. gr. bortezomib, boronophenylalanine) involving gastrointestinal, kidney, hematologic or neural manifestations, the epithelia disturbance manifestations when topic BCCs (tavaborole, crisaborole) are used for skin maladies, or the neuropathy induced for some compounds in industry as dimethylamine borane (Duydu, 2015;Kuo, 2006). Taking into account all above mentioned, it should be emphasized the importance of collection of toxicological data from preclinical studies or intoxications by BCCs-exposure as well as the pharmacovigilance for those BCC which are intentionally administered in humans due to the advisable advantages.…”

Dimethylamine Borane Neurotoxicity

“…The data were further supported by sural nerve biopsy and cutaneous nerve biopsy studies (Kuo et al in press). Our serial nerve conduction studies also confirmed axonal polyneuropathy, particularly in the motor nerves.…”

“…Our time course of DMAB-induced polyneuropathy indicated an acute axonal polyneuropathy (Kuo et al, in press). However, Tsan et al (2005) misdiagnosed the patient as having a delayed polyneuropathy, which may be wrong, because the time course was different from the so-called “delayed polyneuropathy” induced by organophosphate intoxication (Senanyake and Karalliedde 1987).…”

Neurotoxicity due to dimethylamine borane poisoning via skin absorption: a case report

“…Despite nutritional neurotherapy treatment for more than 3 months, motor nerve injury in the patient's lower limbs showed no notable amelioration. Kuo et al [6] conducted a follow-up with the patient who was reported by Tsan et al [1] , indicated that muscle strength and sensory functions in the feet were still abnormal one year after the exposure. Therefore, persistent polyneuropathy is one of the most important concerns in DMAB poisoning.…”

“…[1,4] Isolated reports indicated that DMAB exposure causes acute cerebellar oedema and peripheral neuropathy. [1,5,6] Herein, we report a case of DMAB poisoning via dermal absorption in which the central and peripheral nervous systems were the primary sites of toxic injury. We highlight the use of brain magnetic resonance imaging (MRI) and electromyography (EMG) for evaluation after exposure.…”

Current data regarding the structure-toxicity relationship of boron-containing compounds

“…Among others, the toxicology data for sodium borate related to disruption on reproductive effects, and general manifestations as irritability, disturbed sleeping, vomiting, diarrhea, or anemia; the adverse effects of BCCs used in chemotherapy (v. gr. bortezomib, boronophenylalanine) involving gastrointestinal, kidney, hematologic or neural manifestations, the epithelia disturbance manifestations when topic BCCs (tavaborole, crisaborole) are used for skin maladies, or the neuropathy induced for some compounds in industry as dimethylamine borane (Duydu, 2015;Kuo, 2006). Taking into account all above mentioned, it should be emphasized the importance of collection of toxicological data from preclinical studies or intoxications by BCCs-exposure as well as the pharmacovigilance for those BCC which are intentionally administered in humans due to the advisable advantages.…”

Dimethylamine Borane Neurotoxicity

“…The data were further supported by sural nerve biopsy and cutaneous nerve biopsy studies (Kuo et al in press). Our serial nerve conduction studies also confirmed axonal polyneuropathy, particularly in the motor nerves.…”

“…Our time course of DMAB-induced polyneuropathy indicated an acute axonal polyneuropathy (Kuo et al, in press). However, Tsan et al (2005) misdiagnosed the patient as having a delayed polyneuropathy, which may be wrong, because the time course was different from the so-called “delayed polyneuropathy” induced by organophosphate intoxication (Senanyake and Karalliedde 1987).…”

Neurotoxicity due to dimethylamine borane poisoning via skin absorption: a case report

“…Despite nutritional neurotherapy treatment for more than 3 months, motor nerve injury in the patient's lower limbs showed no notable amelioration. Kuo et al [6] conducted a follow-up with the patient who was reported by Tsan et al [1] , indicated that muscle strength and sensory functions in the feet were still abnormal one year after the exposure. Therefore, persistent polyneuropathy is one of the most important concerns in DMAB poisoning.…”

“…[1,4] Isolated reports indicated that DMAB exposure causes acute cerebellar oedema and peripheral neuropathy. [1,5,6] Herein, we report a case of DMAB poisoning via dermal absorption in which the central and peripheral nervous systems were the primary sites of toxic injury. We highlight the use of brain magnetic resonance imaging (MRI) and electromyography (EMG) for evaluation after exposure.…”

Current data regarding the structure-toxicity relationship of boron-containing compounds

“…Among others, the toxicology data for sodium borate related to disruption on reproductive effects, and general manifestations as irritability, disturbed sleeping, vomiting, diarrhea, or anemia; the adverse effects of BCCs used in chemotherapy (v. gr. bortezomib, boronophenylalanine) involving gastrointestinal, kidney, hematologic or neural manifestations, the epithelia disturbance manifestations when topic BCCs (tavaborole, crisaborole) are used for skin maladies, or the neuropathy induced for some compounds in industry as dimethylamine borane (Duydu, 2015;Kuo, 2006). Taking into account all above mentioned, it should be emphasized the importance of collection of toxicological data from preclinical studies or intoxications by BCCs-exposure as well as the pharmacovigilance for those BCC which are intentionally administered in humans due to the advisable advantages.…”