AXL is an oncotarget in human colorectal cancer

Martinelli, Erika; Martini, Giulia; Cardone, Claudia; Troiani, Teresa; Liguori, Giuseppina; Vitagliano, Donata; Napolitano, Stefania; Morgillo, Floriana; Rinaldi, Barbara; Melillo, Rosa Marina; Liotti, Federica; Nappi, Anna; Bianco, Roberto; Berrino, Liberato; Ciuffreda, Loreta Pia; Ciardiello, Davide; Iaffaioli, Vincenzo Rosario; Botti, Gerardo; Ferraiolo, Fiorella; Ciardiello, Fortunato

doi:10.18632/oncotarget.3962

Cited by 60 publications

(52 citation statements)

References 38 publications

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“…Hence, it has been studied in many conditions. Gas6 and TAM regulate cell growth and an overactivation of the system has been associated to several neoplastic conditions and proposed as a novel therapeutic target [37,38,39,40,41,42,43,44,45,46,47,48]. Furthermore, TAM receptors are involved in haemostasis.…”

Section: The Gas6/tam Receptors Systemmentioning

confidence: 99%

The Gas6/TAM System and Multiple Sclerosis

Bellan

Pirisi

Sainaghi

2016

IJMS

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Growth arrest specific 6 (Gas6) is a multimodular circulating protein, the biological actions of which are mediated by the interaction with three transmembrane tyrosine kinase receptors: Tyro3, Axl, and MerTK, collectively named TAM. Over the last few decades, many progresses have been done in the understanding of the biological activities of this highly pleiotropic system, which plays a role in the regulation of immune response, inflammation, coagulation, cell growth, and clearance of apoptotic bodies. Recent findings have further related Gas6 and TAM receptors to neuroinflammation in general and, specifically, to multiple sclerosis (MS). In this paper, we review the biology of the Gas6/TAM system and the current evidence supporting its potential role in the pathogenesis of MS.

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Section: The Gas6/tam Receptors Systemmentioning

confidence: 99%

The Gas6/TAM System and Multiple Sclerosis

Bellan

Pirisi

Sainaghi

2016

IJMS

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“…11,12 Transcriptome sequencing of 200 surgical tumor samples of lung adenocarcinoma revealed a new Axl - MAP3K12-binding inhibitory protein (MBIP) fusion gene, which preserved Axl tyrosine kinase domain. 13 …”

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confidence: 99%

Axl Receptor Axis: A New Therapeutic Target in Lung Cancer

Levin

Brekken

Byers

et al. 2016

Journal of Thoracic Oncology

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The Axl receptor tyrosine kinase belongs to the TAM (Tyro3, Axl, Mer) family of proteins and is upregulated in multiple types of cancers, including non-small cell lung cancer. In normal tissues, TAM receptor tyrosine kinases contribute to immune regulation. In cancer, Axl expression is associated with poor outcomes and is controlled through various transcriptional and epigenetic mechanisms. Preclinical studies have shown that Axl is involved in cancer cell migration, growth, survival and resistance to chemotherapy through activation of multiple downstream signaling pathways, such as Ras/MAPK, PI3K and Rac1. Axl is also expressed on endothelial cells and plays a role in angiogenesis. In preclinical models, Axl inhibition decreases cancer growth and impedes lung cancer metastases. Small molecule Axl inhibitors have been developed and are currently being used as monotherapy or in combination with cytotoxic chemotherapy or anti-EGFR therapy in early clinical trials. Here, we review Axl structure, functions, regulation, and preclinical and clinical studies in lung cancer.

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“…Carvacrol reduces cell proliferation and its antiproliferative effect is correlated with AXL protein level. AXL has been reported to transduce diverse extracellular signals to cause cell survival, proliferation and inhibition of apoptosis (14,16,(26)(27)(28). We asked if carvacrol alters cell viability, which is related to its inhibitory effect on AXL expression.…”

Section: Resultsmentioning

confidence: 99%