Axis I diagnoses and transition to psychosis in clinical high-risk patients EPOS project: Prospective follow-up of 245 clinical high-risk outpatients in four countries

Salokangas, Raimo K. R.; Ruhrmann, Stephan; Reventlow, H. Graf von; Heinimaa, Markus; Svirskis, T.; From, Tiina; Luutonen, Sinikka; Juckel, Georg; Linszen, Don; Dingemans, Peter; Birchwood, Max; Patterson, Paul; Schultze‐Lutter, Frauke; Klosterkötter, Joachim

doi:10.1016/j.schres.2012.03.008

Cited by 97 publications

(106 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This rate is now considered as typical of prodromal research in general (Niendam et al, 2013;Yaakub et al, 2013;Katsura et al, 2014) and similar to the conversion rates in various consortia, such as the European Prediction of Psychosis Study (Salokangas et al, 2012). These rates reflect a decline in conversion since the time of the original reports in CHR samples (Yung et al, 2007).…”

Section: Neural Dysfunction In Cognitive Control Circuits T Colibazzisupporting

confidence: 68%

Neural Dysfunction in Cognitive Control Circuits in Persons at Clinical High-Risk for Psychosis

Colibazzi

Horga

Wang

et al. 2015

Neuropsychopharmacol

View full text Add to dashboard Cite

Cognitive control, a set of functions that develop throughout adolescence, is important in the pathogenesis of psychotic disorders. Whether cognitive control has a role in conferring vulnerability for the development of psychotic illness is still unknown. The aim of this study was to investigate the neural systems supporting cognitive control in individuals deemed to be potentially prodromal for psychotic illness. We recruited 56 participants at clinical high-risk (CHR) for psychosis based on the Structured Interview for Psychosis-Risk Syndromes (SIPS) and 49 healthy controls. Twelve of the CHR participants eventually developed psychosis. We compared functional magnetic resonance imaging (fMRI) BOLD signal during the performance of the Simon task. We tested for differences between CHR individuals and controls in conflict-related functional activity. In the CHR group when compared with controls, we detected smaller conflictrelated activations in several cortical areas, including the Dorsolateral Prefrontal Cortex (DLPFC). Furthermore, conflict-related activations in the DLPFC of those CHR individuals who ultimately developed psychosis (CHR converters) were smaller than in non-converters (CHR non-converters). Higher levels of conflict-related activation were associated with better social and role outcome. Risk for psychosis was associated at the neural level with reduced conflict-related brain activity. This neural phenotype appears correlated within the DLPFC with the development of psychosis and with functional outcome.

show abstract

Section: Neural Dysfunction In Cognitive Control Circuits T Colibazzisupporting

confidence: 68%

Neural Dysfunction in Cognitive Control Circuits in Persons at Clinical High-Risk for Psychosis

Colibazzi

Horga

Wang

et al. 2015

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…One possibility is that subjects in the HR group will never develop schizophrenia or any psychiatric illness. Alternatively, a percentage of HR individuals may progress to schizophrenia 55,56 or may transition to other psychiatric disorders. 57 Thus, it is possible that within the HR group, there is a subset of individuals who would show a connectivity pattern more similar to that of the EC-SCZ group eventually.…”

Section: Amygdala-orbitofrontal Connectivity Is Altered In Chronic Anmentioning

confidence: 99%

Amygdala Connectivity Differs Among Chronic, Early Course, and Individuals at Risk for Developing Schizophrenia

Antičević¹,

Tang

Cho

et al. 2013

Schizophrenia Bulletin

View full text Add to dashboard Cite

Alterations in circuits involving the amygdala have been repeatedly implicated in schizophrenia neuropathology, given their role in stress, affective salience processing, and psychosis onset. Disturbances in amygdala whole-brain functional connectivity associated with schizophrenia have yet to be fully characterized despite their importance in psychosis. Moreover, it remains unknown if there are functional alterations in amygdala circuits across illness phases. To evaluate this possibility, we compared whole-brain amygdala connectivity in healthy comparison subjects (HCS), individuals at high risk (HR) for schizophrenia, individuals in the early course of schizophrenia (EC-SCZ), and patients with chronic schizophrenia (C-SCZ). We computed whole-brain resting-state connectivity using functional magnetic resonance imaging at 3T via anatomically defined individual-specific amygdala seeds. We identified significant alterations in amygdala connectivity with orbitofrontal cortex (OFC), driven by reductions in EC-SCZ and C-SCZ (effect sizes of 1.0 and 0.97, respectively), but not in HR for schizophrenia, relative to HCS. Reduced amygdala-OFC coupling was associated with schizophrenia symptom severity (r = .32, P < .015). Conversely, we identified a robust increase in amygdala connectivity with a brainstem region around noradrenergic arousal nuclei, particularly for HR individuals relative to HCS (effect size = 1.54), but not as prominently for other clinical groups. These results suggest that deficits in amygdala-OFC coupling could emerge during the initial episode of schizophrenia (EC-SCZ) and may present as an enduring feature of the illness (C-SCZ) in association with symptom severity but are not present in individuals with elevated risk for developing schizophrenia. Instead, in HR individuals, there appears to be increased connectivity in a circuit implicated in stress response.

show abstract

“…Prospective research in CHR samples yields similar findings, with many cases meeting criteria for at least 1 life-time/current diagnosis, and half having a life-time diagnosis of depressive or anxiety disorder. 12,69 Thus, as with psychotic disorders, the psychosis prodrome is characterized by a high rate of comorbid psychiatric syndromes. In the absence of a formal diagnostic category, those with attenuated positive symptoms will continue to be diagnosed from typically co-occurring symptoms or syndromes.…”

Section: Diagnostic Dilemmasmentioning

confidence: 99%

The Prodrome and Clinical Risk for Psychotic Disorders

Holtzman

Trotman

Ryan

et al. 2013

Child and Adolescent Psychiatric Clinics of North America

View full text Add to dashboard Cite

Axis I diagnoses and transition to psychosis in clinical high-risk patients EPOS project: Prospective follow-up of 245 clinical high-risk outpatients in four countries

Cited by 97 publications

References 24 publications

Neural Dysfunction in Cognitive Control Circuits in Persons at Clinical High-Risk for Psychosis

Neural Dysfunction in Cognitive Control Circuits in Persons at Clinical High-Risk for Psychosis

Amygdala Connectivity Differs Among Chronic, Early Course, and Individuals at Risk for Developing Schizophrenia

The Prodrome and Clinical Risk for Psychotic Disorders

Contact Info

Product

Resources

About