Awara (Astrocaryum vulgare M.) pulp oil: Chemical characterization, and anti-inflammatory properties in a mice model of endotoxic shock and a rat model of pulmonary inflammation

Bony, Emilie; Boudard, F.; Brat, Pierre; Dussossoy, Emilie; Portet, Karine; Poucheret, Patrick; Gadrey, Jean; Michel, Alain

doi:10.1016/j.fitote.2011.09.007

Cited by 42 publications

(26 citation statements)

References 49 publications

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“…The total phenolic content (TPC) was evaluated using Folin-Ciocalteu's method. 11 The TPC samples were calculated as a gallic acid equivalent from the calibration curve of gallic acid standard solutions (5,10,15,20,25, and 30 lg/mL) of 0.2% aqueous gallic acid that followed the same method. The equation obtained for the calibration curve of gallic acid was y = 18.185x -0.0266 (R 2 = 0.9783).…”

Section: Tucuma Extract Production and Chemical Characterizationmentioning

confidence: 99%

“…8 Previous studies defined other bioactive compounds in tucuma pulp as catechins (79 -5 mg/100 g sample dry weight), quercetin (2.96 -0.05 mg/100 g sample dry weight) a general antioxidant capacity as well as antiinflammatory activity. 9,10 Within this context, the tucuma extracts from peel and pulp could represent a potential effect on human health. However, it will be important to determine the range of concentrations that do not present toxic effects on cells.…”

Section: Introductionmentioning

confidence: 99%

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TheIn VitroGenotoxic Effect of Tucuma (Astrocaryum aculeatum), an Amazonian Fruit Rich in Carotenoids

Filho

Sagrillo²,

Garcia³

et al. 2013

Journal of Medicinal Food

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Tucuma (Astrocaryum aculeatum) is an Amazonian fruit that presents high levels of carotenoids and other bioactive compounds such as quercetin. The extracts of tucuma peel and pulp present strong antioxidant activity which illustrate an elevated concentration that causes cytotoxic effects in human peripheral blood mononuclear cells (PBMCs). This study performed additional investigations to analyze the potential genotoxic effects of the tucuma extracts on PBMCs. The genotoxicity was evaluated by DNA fragmentation, Comet assay, and chromosomal instability G-band assays. The acute tucuma extract treatment showed genoprotective effects against DNA denaturation when compared with untreated PBMC cells. However, in the experiments with 24 and 72 h treatments to tucuma treatments, we observed low genotoxicity through a concentration of 100 μg/mL, some genotoxic effects related to intermediary concentrations (100-500 μg/mL), and more pronounced genotoxic effects on higher tucuma extract concentrations. After 24 h of treatment, the reactive oxygen species were similar among treatments and PBMC control groups. However, the caspase-1 activity related to the apoptosis and pyroptosis process increased significantly in higher tucuma concentrations. In summary, tucuma extracts, despite their higher antioxidant content and antioxidant activity, would present PBMCs genotoxic effects that are dependent on concentration and time exposition. These results need to be considered in future in vitro and in vivo studies of tucuma effects.

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Section: Tucuma Extract Production and Chemical Characterizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

TheIn VitroGenotoxic Effect of Tucuma (Astrocaryum aculeatum), an Amazonian Fruit Rich in Carotenoids

Filho

Sagrillo²,

Garcia³

et al. 2013

Journal of Medicinal Food

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“…Of particular interest is Astrocaryum vulgare oil, commonly called tucumã in Brazil, from a plant that belongs to the Arecaceae family, and used as food due to its high carotenoid content in the pulp oil (Khan, ). The potent antioxidant activity of tucumã is well reported in the literature (Bonnafous, Viton, & Maraval, ), as well as its anti‐inflammatory properties (Bony et al, ). Based on these findings, tucumã has become an attractive therapeutic agent to treat a variety of pathologies, including diabetes (Baldissera et al, ).…”

Section: Introductionmentioning

confidence: 82%

Tucumã oil (Astrocaryum vulgare) ameliorates hepatic antioxidant defense system in alloxan-induced diabetic mice

et al. 2017

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The aim of this study was to investigate whether treatment with Astrocaryum vulgare oil (tucumã oil), a hypoglycemic natural compound, was able to reduce hepatic oxidative stress of diabetic mice. An increase in lipid peroxidation and decrease in catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione S-transferase (GST) activities, as well as glutathione reductase (GSH) levels were observed in diabetic/water group. Treatment with tucumã oil prevented lipid peroxidation and inhibition of CAT and SOD activities in diabetic mice. The tucumã oil treatment may provide effective protection against lipid oxidative damage in the liver tissue of diabetic mice, since it improved the enzymatic antioxidant defense system. Therefore, the tucumã oil can be an important coadjutant in the treatment of diabetes, contributing to the prevention and reduction of oxidative damage. Practical applicationsRecently, it was demonstrated that tucumã oil exerts potent antihyperglycemic effect in alloxaninduced diabetic mice. The oil improved the pancreatic oxidant/antioxidant status, playing an essential role in the hypoglycemic effect. The results showed that tucumã oil can reduce oxidative stress in liver tissue, and consequently, prevent the hepatic alterations caused by high glucose levels. K E Y W O R D Santioxidant, catalase, glucose, lipid peroxidation, liver

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“…Venezuela and Trinidad and Tobago [4]. Several biological activities, including anti-inflammatory [5,6], antibacterial and antifungal [7] properties have been reported for Astrocaryum species. Their fruits are important sources of minerals, including potassium, calcium, selenium and present great amounts of fatty acids [8], being indicated for the treatment of skin and eye diseases [9].…”

mentioning

confidence: 99%

“…Their fruits are important sources of minerals, including potassium, calcium, selenium and present great amounts of fatty acids [8], being indicated for the treatment of skin and eye diseases [9]. Tocopherols, phytosterols, quercetin, rutin, gallic and cafeic acids have also been previously described as chemical constituents of tucumã [5,7,10,11]. Due to its high nutritional value and pleasant taste, tucumã fruits are widely consumed by local population as food, being used in natura and to produce ice cream, dessert, cakes and sandwiches [12,13].…”

mentioning

confidence: 99%

Development of Nanoemulsions with Tucumã (Astrocaryum vulgare) Fruits Oil

Silva¹,

Hyacienth²,

Ferreira³

et al. 2015

JNMR

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Astrocaryum vulgare is a palm species which belongs to the family Arecaeae, being commonly known as tucumã and widely distributed through Amazon. Tucumã fruit is a typically Amazonian raw material, which can be used for extraction of oil with great economic importance. However, to our knowledge, tucumã remain unexplored concerning development of a nanobiotechnology product. The aim of the present study was to develop nanoemulsions containing tucumã fruits oil. Formulations prepared with different blends of sorbitan monooleate and

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Awara (Astrocaryum vulgare M.) pulp oil: Chemical characterization, and anti-inflammatory properties in a mice model of endotoxic shock and a rat model of pulmonary inflammation

Cited by 42 publications

References 49 publications

TheIn VitroGenotoxic Effect of Tucuma (Astrocaryum aculeatum), an Amazonian Fruit Rich in Carotenoids

TheIn VitroGenotoxic Effect of Tucuma (Astrocaryum aculeatum), an Amazonian Fruit Rich in Carotenoids

Tucumã oil (Astrocaryum vulgare) ameliorates hepatic antioxidant defense system in alloxan-induced diabetic mice

Development of Nanoemulsions with Tucumã (Astrocaryum vulgare) Fruits Oil

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