2006
DOI: 10.1590/s0004-27302006000600012 View full text |Buy / Rent full text
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Abstract: RESUMOObjetivo: O objetivo deste trabalho é determinar a prevalência do polimorfismo C677T do gene metilenotetraidrofolato redutase (MTHFR) e associá-la com a concentração plasmática de homocisteína plasmáti-ca na doença arterial coronariana (DAC). Métodos: Foram avaliados 93 pacientes com DAC documentada, atendidos no Hospital Universitário Oswaldo Cruz (Recife, PE, Brasil), e 108 controles sem a doença. Foram determinados os perfis lipídicos de pacientes e controles. As concentrações plasmáticas de homociste… Show more

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“…Atherosclerosis, a common framework in cardiac patients, is the leading cause of stroke. In 1969, McCully reported an association between atherosclerosis and high concentrations of homocysteine, data subsequently confirmed by other studies (Brattströ m et al, 1994;Graham et al, 1997;Muniz et al, 2006).…”
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“…Atherosclerosis, a common framework in cardiac patients, is the leading cause of stroke. In 1969, McCully reported an association between atherosclerosis and high concentrations of homocysteine, data subsequently confirmed by other studies (Brattströ m et al, 1994;Graham et al, 1997;Muniz et al, 2006).…”
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“…Some authors have hypothesized the association of MTHFR variants, such as C677T and A1298C polymorphisms, with CVD (due to the influence of such polymorphisms on the plasma concentration of homocysteine), with conflicting results. Muniz et al (2006) found an association between high levels of homocysteine and CVD but no relationship between the mutant T allele and plasma levels of homocysteine; these data were later confirmed by Guerzoni et al (2009). On the other hand, Harmon et al (1996) demonstrated a relationship between the 677TT genotype and elevated levels of homocysteine; Spotilla et al later confirmed these findings (2003).…”
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“…With this in mind, some studies have correlated the C677T and A1298C polymorphisms within MTHFR gene with elevated levels of plasma homocysteine and/or with an increased risk of CVD [21,38,95,105,129], while other studies have not found such associations [15,59,65,97]. Besides other risk factors involved, ethnic and geographic variations in the allele frequencies of these polymorphisms could perhaps explain these controversial results.…”
Section: Discussionmentioning
“…Kebert et al (2006) 24 observaram 66,2% de indivíduos portadores do alelo MTHFR 677C e 33,8% portadores do alelo MTHFR 677T em população caucasóide com DAC. Estudo em população brasileira mostrou resultado semelhante e sugere que o polimorfismo C677T da MTHFR não é um fator de risco independente para DAC 17 . A frequência do alelo polimórfico MTHFR 677T foi de 0,24 nos indivíduos com DAC.…”
Section: Discussionunclassified
“…A associação do polimorfismo MTHFR C677T com DAC foi confirmada por alguns estudos, nos quais a prevalência de portadores do alelo alterado foi maior no grupo DAC em relação aos controles [10][11][12][13][14] por outro lado, outros trabalhos não confirmam tal associação 15,16,17 . Em relação ao polimorfismo MTHFR A1298C, o alelo alterado foi associado com início precoce da DAC, independente dos níveis de Hcy 9 .…”
Section: Introductionunclassified