Avaliação clínica do quinino para o tratamento de malária por Plasmodium falciparum

Boulos, Marcos; Dutra, Araripe Pacheco; DiSanti, Silvia Maria; Shiroma, M; Neto, Vicente Amato

doi:10.1590/s0037-86821997000300007

Cited by 19 publications

(14 citation statements)

References 2 publications

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“…However, its synthetic production by industrial means is both complex and costly. Quinine is still used today, and it is currently derived by extraction from the Cinchona spp., which grow wild in South America and are cultivated in Java (Boulos et al 1997).…”

Section: Plant-derived Antimalarial Agentsmentioning

confidence: 99%

Plant-derived antimalarial agents: new leads and efficient phythomedicines. Part I. Alkaloids

Oliveira

Dolabela

Braga

et al. 2009

An. Acad. Bras. Ciênc.

127

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Malaria remains one of the most serious world health problem and the major cause of mortality and morbidity in the endemic regions. Brazil is among the 30 high-burden countries and most of the cases occur in the Legal Amazonian Region. New chemotherapeutical agents are needed for the treatment of malaria. Many plant species are used in traditional medicines of malarious countries and a relatively few number of these have been investigated for evaluation of their antimalarial effect. Still lower is the number of those that have had the active natural compounds isolated and the toxicity determined. This area is, then, of great research interest. A discovery project of antimalarial natural products from plants traditionally used to treat malaria must include in vitro and in vivo assays as well as bioguided isolation of active compounds. The final products would be antimalarial chemical entities, potential new drugs or templates for new drugs development, and/or standardized antimalarial extracts which are required for pre-clinical and clinical studies when the aim is the development of effective and safe phythomedicines. This review discusses these two approaches, presents briefly the screening methodologies for evaluation of antimalarial activity and focuses the activity of alkaloids belonging to different structural classes as well as its importance as new antimalarial drugs or leads and chemical markers for phytomedicines.

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Section: Plant-derived Antimalarial Agentsmentioning

confidence: 99%

Plant-derived antimalarial agents: new leads and efficient phythomedicines. Part I. Alkaloids

Oliveira

Dolabela

Braga

et al. 2009

An. Acad. Bras. Ciênc.

127

View full text Add to dashboard Cite

show abstract

“…For malaria, especially in the book by Pereira et al (2009), the statement was found that drugs containing quinine and derivatives can help prevent the disease, but Boulos et al (1997) warn of the toxic effects that quinine can cause in the organism and the low effect that it has if administered for fewer than 7 days. These facts are not detailed in the analyzed book.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Approach to Parasitic Cycles in Brazilian Science Textbooks as a Tool for Education in Health and Environment

Simplicio¹,

Cordova²,

Oliveira-Filho³

2016

INT J ENV SCI ED

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Modifying the environment is a characteristic of the human species. With deforestation and the expansion of urban centers, diseases known in animals have begun to be described in humans. Science textbooks constitute an instrument of great importance in understanding this issue. This study evaluated the main science textbooks, recommended by the Brazilian Textbook Guide 2011, for the 6th grade of middle school, covering the parasite cycles and analyzing the vector/host relationships as well as man's participation as an inducer/victim. The final analysis showed that most textbooks link image and text, but the cycles are presented off-scale and there are gaps which hinder the understanding of reality. As regards the environmental question, none of the analyzed books presented human beings as an inducer of cycles, and only a few reported the lack of sanitation, urban infrastructure and environmental degradation as causes of disease.

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“…Dentre eles, 13 (33%) investigaram algum tratamento previsto no protocolo oficial 16,17,18,19,20,21,22,23,24,25,26,27,28 . A Tabela 2 mostra que dos 2 fármacos isolados e das 5 associações medicamentosas recomendadas pelo protocolo oficial, apenas 4, entre ambas as categorias, foram avaliadas em estudos nacionais.…”

Section: Artigos Brasileiros Contemplando Fármacos E Associações Recounclassified

“…Seis, dentre os treze estudos identificados, foram publicados antes de 2001 16,20,23,24,25,27 , sendo, portanto, potenciais fontes de informação para a elaboração do Manual de Terapêutica da Malária. Cinco são trabalhos originais e um é revisão narrativa -não sistemática, e assim, não classificável (Tabela 1).…”

Section: Artigos Brasileiros Contemplando Fármacos E Associações Recounclassified

Malária não complicada por Plasmodium vivax e P. falciparum no Brasil: evidências sobre fármacos isolados e associações medicamentosas empregados em esquemas terapêuticos recomendados pelo protocolo terapêutico oficial

et al. 2007

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A malária é a endemia parasitária mais importante no mundo. No Brasil, 60% do território são favoráveis à transmissão, com cerca de 500 mil casos por ano. A doença não se distribui geograficamente de forma homogênea, fato que pode explicar diferenças na eficácia e efetividade dos tratamentos. Para identificar as evidências que poderiam ter embasado os tratamentos recomendados pelo Manual de Terapêutica da Malária 2001, foi realizada uma revisão dos estudos que abordassem tratamentos com antimaláricos no Brasil entre 1980 e 2005. Foram encontrados poucos estudos, e com baixa qualidade metodológica, nenhum deles capaz de gerar recomendações para protocolos baseados em evidência. Os artigos publicados após 2001 apresentaram nível de evidência maior, segundo classificação utilizada para definição de níveis de evidência farmacológico-clínicos. Espera-se que tais estudos também orientem conduta na próxima revisão do manual, prevista para o ano de 2007. Constatou-se que as referências do manual, utilizadas como base para recomendação dos tratamentos, são publicações desatualizadas e possivelmente consideradas clássicas, mas com pouca especificidade para região geográfica, população e/ou tipo de malária.

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Avaliação clínica do quinino para o tratamento de malária por Plasmodium falciparum

Cited by 19 publications

References 2 publications

Plant-derived antimalarial agents: new leads and efficient phythomedicines. Part I. Alkaloids

Plant-derived antimalarial agents: new leads and efficient phythomedicines. Part I. Alkaloids

Analysis of the Approach to Parasitic Cycles in Brazilian Science Textbooks as a Tool for Education in Health and Environment

Malária não complicada por Plasmodium vivax e P. falciparum no Brasil: evidências sobre fármacos isolados e associações medicamentosas empregados em esquemas terapêuticos recomendados pelo protocolo terapêutico oficial

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