Abstract:Adenosine deaminase acting on RNA (ADAR1) catalyzes the hydrolytic deamination of adenosine (A) to inosine (I) in double-stranded RNA (dsRNA). There are 2 isoforms of ADAR1 (p110 in the nucleus; p150 in cytoplasm) and both modify self dsRNA in coding and non-coding regions. The ADAR1 p150 isoform is expressed from an interferon (IFN)-responsive promoter and has a Z-DNA/Z-RNA binding domain at the N-terminus. Previous reports have provided a strong rationale for the development of ADAR1 p150 inhibitors for canc… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.