Auxin and ethylene: collaborators or competitors?

Muday, Gloria K.; Rahman, Abidur; Binder, Brad M.

doi:10.1016/j.tplants.2012.02.001

Cited by 387 publications

(331 citation statements)

References 160 publications

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“…Notably, while ETT appears to repress most of its auxin signaling-related targets (targets upregulated in ett-3), ETT emerged as a positive regulator of most of its ethyleneand JA-related targets (reduced in ett-3). These data agree with the proposed role of auxin in promoting both ethylene and JA synthesis (Muday et al, 2012;Chandler, 2009).…”

Section: Ett Directly Controls Expression Of Specific Gene Classessupporting

confidence: 91%

Auxin-Induced Modulation of ETTIN Activity Orchestrates Gene Expression in Arabidopsis

et al. 2017

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The phytohormone auxin governs crucial developmental decisions throughout the plant life cycle. Auxin signaling is effectuated by auxin response factors (ARFs) whose activity is repressed by Aux/IAA proteins under low auxin levels, but relieved from repression when cellular auxin concentrations increase. ARF3/ETTIN (ETT) is a conserved noncanonical Arabidopsis thaliana ARF that adopts an alternative auxin-sensing mode of translating auxin levels into multiple transcriptional outcomes. However, a mechanistic model for how this auxin-dependent modulation of ETT activity regulates gene expression has not yet been elucidated. Here, we take a genome-wide approach to show how ETT controls developmental processes in the Arabidopsis shoot through its auxin-sensing property. Moreover, analysis of direct ETT targets suggests that ETT functions as a central node in coordinating auxin dynamics and plant development and reveals tight feedback regulation at both the transcriptional and protein-interaction levels. Finally, we present an example to demonstrate how auxin sensitivity of ETT-protein interactions can shape the composition of downstream transcriptomes to ensure specific developmental outcomes. These results show that direct effects of auxin on protein factors, such as ETT-TF complexes, comprise an important part of auxin biology and likely contribute to the vast number of biological processes affected by this simple molecule.

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Section: Ett Directly Controls Expression Of Specific Gene Classessupporting

confidence: 91%

Auxin-Induced Modulation of ETTIN Activity Orchestrates Gene Expression in Arabidopsis

et al. 2017

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“…cell cycle progression and asymmetric division, and integrating responses to a number of hormones modulating this process, as described in recent reviews (Overvoorde et al, 2010;Muday et al, 2012;Lavenus et al, 2013;Van Norman et al, 2013). Of particular relevance to this study is a role of auxin transport in root development (Petrásek and Friml, 2009;Grunewald and Friml, 2010;Laskowski, 2013).…”

Section: Discussionmentioning

confidence: 93%

The anthocyanin reduced Tomato Mutant Demonstrates the Role of Flavonols in Tomato Lateral Root and Root Hair Development

2014

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This study utilized tomato (Solanum lycopersicum) mutants with altered flavonoid biosynthesis to understand the impact of these metabolites on root development. The mutant anthocyanin reduced (are) has a mutation in the gene encoding FLAVONOID 3-HYDROXYLASE (F3H), the first step in flavonol synthesis, and accumulates higher concentrations of the F3H substrate, naringenin, and lower levels of the downstream products kaempferol, quercetin, myricetin, and anthocyanins, than the wild type. Complementation of are with the p35S:F3H transgene reduced naringenin and increased flavonols to wild-type levels. The initiation of lateral roots is reduced in are, and p35S:F3H complementation restores wild-type root formation. The flavonoid mutant anthocyanin without has a defect in the gene encoding DIHYDROFLAVONOL REDUCTASE, resulting in elevated flavonols and the absence of anthocyanins and displays increased lateral root formation. These results are consistent with a positive role of flavonols in lateral root formation. The are mutant has increased indole-3-acetic acid transport and greater sensitivity to the inhibitory effect of the auxin transport inhibitor naphthylphthalamic acid on lateral root formation. Expression of the auxin-induced reporter (DR5-b-glucuronidase) is reduced in initiating lateral roots and increased in primary root tips of are. Levels of reactive oxygen species are elevated in are root epidermal tissues and root hairs, and are forms more root hairs, consistent with a role of flavonols as antioxidants that modulate root hair formation. Together, these experiments identify positive roles of flavonols in the formation of lateral roots and negative roles in the formation of root hairs through the modulation of auxin transport and reactive oxygen species, respectively.

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“…Segundo esses autores, após a enxertia, quando as conexões vasculares estão sendo estabelecidas, a auxina produzida na cultivar é translocada para o sistema radicular, onde atinge concentrações muito elevadas, que desencadeiam um processo de degradação e deterioração das raízes. Estudos convergentes ainda sugerem que os níveis elevados de auxina podem ser causados por uma síntese elevada de etileno (ALONI et al, 2010;MUDAY et al, 2012), hormônio que estimula, através de sua via de sinalização, a biossíntese de auxina em diferentes órgãos da planta, além, de aumentar a capacidade de transporte de auxina, pois regula a transcrição dos seus componentes de transporte, como AUX1 e PIN2 (IVANCHENKO et al, 2008;ALONI et al, 2010;MUDAY et al, 2012). O etileno pode ainda induzir estresse oxidativo pela produção de células reativas de oxigênio (ALONI et al, 2010;HURR et al, 2013), provocando crescimento reduzido e problemas de compatibilidade (MOGHADAM et al, 2012).…”

Section: Hormôniosunclassified