Autosomal Dominant Polycystic Kidney Disease Is Not a Risk Factor for Post-transplant Diabetes Mellitus. Matched-pair Design Multicenter Study

“…Complications directly related to ADPKD are rare. Whether ADPKD increases the risk for developing new onset diabetes mellitus after transplantation is controversial 141,142. When nephrectomy is indicated, hand-assisted laparoscopic nephrectomy is associated with less intraoperative blood loss, less postoperative pain, and a faster recovery compared with open nephrectomy and is increasingly being used 143–145…”

Section: Treatmentmentioning

confidence: 99%

Autosomal dominant polycystic kidney disease: the last 3 years

Torres

Harris

2009

Kidney International

517

449

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Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal monogenic disorder. It has large inter- and intra-familial variability explained to a large extent by its genetic heterogeneity and modifier genes. An increased understanding of its underlying genetic, molecular, and cellular mechanisms and a better appreciation of its progression and systemic manifestations have laid out the foundation for the development of clinical trials and potentially effective therapies. The purpose of this review is to update the core of knowledge in this area with recent publications that have appeared during 2006–2009.

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“…However, this conclusion was not supported by all research groups [11] . In the population of renal transplant recipients with a history of ADPKD, the percentage of PTDM ranged from 13.4% in the study by Hamer et al [9] to 23.8% in the study by Gentil et al [10] , while in the study by de Mattos et al [8] this ratio was 17%.…”

mentioning

confidence: 61%

“…It must be noted that in our previous study on renal transplant recipients (RTRs) with ADPKD [11] body mass and BMI were significantly higher than among non-AD-PKD kidney-transplanted patients (71. Data published by Vareesangthip et al [17] indicate that in the group of ADPKD patients with normal kidney function (mean creatinine 0.97 mg/dl, mean creatinine clearance 102 ml/min/1.73 m 2 ), mean BMI value was 22.8, with a mean cholesterol (CT) level of 197 mg/dl and a mean triglyceride (TG) concentration of 80 mg/dl.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome Components in Patients with Autosomal-Dominant Polycystic Kidney Disease

Pietrzak-Nowacka¹,

Safranow²,

Byra³

et al. 2009

Kidney Blood Press Res

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Background: The aim of this work was to compare the prevalence of the metabolic syndrome (MS) and its components between a group of autosomal-dominant polycystic kidney disease (ADPKD) patients with normal kidney function and no prior diagnosis of diabetes and healthy controls. Methods: Forty-nine patients with ADPKD (age 35.9 ± 11.1 years) with serum creatinine <1.35 mg/dl and 50 healthy controls (36.7 ± 9.2 years) were enrolled for the study. Physical examination, basic laboratory measurements and oral glucose tolerance test were performed in all subjects. Results: In the group of ADPKD patients, when compared to controls, the following values were significantly higher: waist-to-hip ratio (0.84 ± 0.09 vs. 0.81 ± 0.10, p = 0.046), systolic blood pressure (133.9 ± 19.8 vs. 122.2 ± 14.9 mm Hg, p = 0.0023), diastolic blood pressure (92.9 ± 12.4 vs. 82.9 ± 9.3 mm Hg, p < 0.0001), fasting glycemia (91.6 ± 10.5 vs. 84.5 ± 9.2 mg/dl, p = 0.04), and HbA_1C (5.41 ± 0.35 vs. 5.28 ± 0.33%, p = 0.06, borderline significance). Adult Treatment Panel III criteria of MS were fulfilled by 14% of patients and 14% of controls, while International Diabetes Federation criteria were fulfilled by 22% of patients and 20% of controls, without any significant difference between the groups. Conclusion: The presence of ADPKD with normal kidney function is associated with components of MS such as hypertension, abdominal obesity and higher fasting glycemia.

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Autosomal Dominant Polycystic Kidney Disease Is Not a Risk Factor for Post-transplant Diabetes Mellitus. Matched-pair Design Multicenter Study

Cited by 19 publications

References 29 publications

Management of ESRD in Patients With Autosomal Dominant Polycystic Kidney Disease

Management of ESRD in Patients With Autosomal Dominant Polycystic Kidney Disease

Autosomal dominant polycystic kidney disease: the last 3 years

Metabolic Syndrome Components in Patients with Autosomal-Dominant Polycystic Kidney Disease

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