Autopsy in a Neonatal Intensive Care Unit: pathological and clinical agreement

Penso, Camila; Corso, Andrea; Hentges, Cláudia Regina; Silveira, Rita de Cássia dos Santos; Rivero, Raquel Camara; Rojas, Bruna Schafer; Tellechea, Tatiana S; Procianoy, Renato S.

doi:10.1016/j.jped.2022.01.002

Cited by 4 publications

(5 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A total of 170 articles were included in the final review (alphabetically ordered based on author in Supplementary Table 2). 1,2,7–50,55,56,68–189 A PRISMA flow diagram is presented to track the process and number of studies included and excluded (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Genetic counselling considerations with genetic/genomic testing in Neonatal and Pediatric Intensive Care Units: A scoping review

Kim,

Pistawka,

Langlois

et al. 2023

Clinical Genetics

View full text Add to dashboard Cite

Genetic and genomic technologies can effectively diagnose numerous genetic disorders. Patients benefit when genetic counselling accompanies genetic testing and international guidelines recommend pre‐ and post‐test genetic counselling with genome‐wide sequencing. However, there is a gap in knowledge regarding the unique genetic counselling considerations with different types of genetic testing in the Neonatal Intensive Care Unit (NICU) and the Pediatric Intensive Care Unit (PICU). This scoping review was conducted to identify the gaps in care with respect to genetic counselling for infants/pediatric patients undergoing genetic and genomic testing in NICUs and PICUs and understand areas in need of improvement in order to optimize clinical care for patients, caregivers, and healthcare providers. Five databases (MEDLINE [Ovid], Embase [Ovid], PsycINFO [Ebsco], CENTRAL [Ovid], and CINHAL [Ebsco]) and grey literature were searched. A total of 170 studies were included and used for data extraction and analysis. This scoping review includes descriptive analysis, followed by a narrative account of the extracted data. Results were divided into three groups: pre‐test, post‐test, and comprehensive (both pre‐ and post‐test) genetic counselling considerations based on indication for testing. More studies were conducted in the NICU than the PICU. Comprehensive genetic counselling was discussed in only 31% of all the included studies demonstrating the need for both pre‐test and post‐test genetic counselling for different clinical indications in addition to the need to account for different cultural aspects based on ethnicity and geographic factors.

show abstract

Section: Resultsmentioning

confidence: 99%

“…For this category, there were overlapping general recommendations to provide genetic counselling for future pregnancies upon understanding the genetic cause of infant deaths. 73,88,110,122,125,129,140,154,158…”

Section: Neonatal/pediatric Deathmentioning

confidence: 99%

Genetic counselling considerations with genetic/genomic testing in Neonatal and Pediatric Intensive Care Units: A scoping review

Kim,

Pistawka,

Langlois

et al. 2023

Clinical Genetics

View full text Add to dashboard Cite

show abstract

“…In a neonatal autopsy study conducted in Brazil, postmortem pathological diagnosis added 34% new findings to the neonatal specialist diagnosis; in 6.9% of cases, relatives were referred to genetic counseling; and in 9.6% of cases, results were reached that would have changed the treatment modality if caught in the premortem stage. [ 36 ]…”

Section: Discussionmentioning

confidence: 99%

Causes of sudden neonatal mortality disclosed by autopsy and histopathological examination

Özdemir Kara

2023

Medicine

View full text Add to dashboard Cite

The neonatal period, or the first 28 days of life, is the most vulnerable time in a child’s life. Neonatal mortality has decreased in recent years. However, this progress varies at the national level, which necessitates actual regional data from different countries to identify local handicaps for life-saving precautions. This study aimed to investigate the causes for neonatal deaths as revealed by autopsy and histopathological examinations. A retrospective cross-sectional study was designed to identify the main causes of neonatal deaths in children who were autopsied at our institution between January 1, 2014, and December 31, 2021. Children who died within the first 28 days after birth (1–28 days of age) were referred to as neonatal cases. The main causes of neonatal death in children were determined via autopsy and histopathological and toxicological examinations. Furthermore, the causes of death were classified according to their manner of death. During this period, 122 neonatal children were autopsied at our institution. This group comprised 57 girls and 65 boys. For the manner of the death, natural causes were the most common cause (n = 91, 74.5%). Among natural causes, pneumonia (n = 66) was the leading one, representing 54% of all neonatal deaths, followed by perinatal conditions (n = 16, 13.1%). One of the pioneering reasons for death was sudden, unexpected postnatal collapse (n = 24, 19.6%), which was categorized under the undetermined group considering the manner of death. Unintentional (accidental) deaths accounted for 0.8% (n = 1) of total deaths, and intentional deaths were responsible for 6 neonates (4.9%) losses. This study shows that newborn children still die from simple and treatable infectious causes, probably arising from various familial and/or public inadequacies. In addition, sudden and unexpected postnatal collapse remains an important cause of neonatal mortality that has yet to be fully resolved. This study points out valuable inferences for caregivers and competent authorities to take preventive measures to prevent avoidable neonatal deaths.

show abstract

“…described postmortem findings of infants who died while being admitted to a large neonatal intensive care unit in the southern part of Brazil. 1 …”

mentioning

confidence: 99%

“…Penso and co-authors have demonstrated that in more than one-third of cases additional findings were obtained from neonatal autopsies, which contributed to subsequent genetic counseling or would have changed patient management if the knowledge had been present antemortem. 1 …”

mentioning

confidence: 99%