2011
DOI: 10.1101/sqb.2012.76.011015 View full text |Buy / Rent full text
|
|

Abstract: Altered metabolism is a hallmark of cancer. Oncogenic events that lead to cancerous states reorganize metabolic pathways to increase nutrient uptake, which promotes biosynthetic capabilities and cell-autonomous behavior. Increased biosynthesis dictates metabolic demand for ATP, building blocks, and reducing equivalents, rendering cancer cells metabolically in a perpetually hungry state. Moreover, most chemotherapy agents induce acute metabolic stress that cancer cells must overcome for their survival. These me… Show more

Help me understand this report

Search citation statements

Order By: Relevance
0
0
0
0
0
3
100
0

Publication Types

Select...

Relationship

0
0

Authors

Journals