Autophagy inhibition mediated by intrauterinemiR‐1912‐3p/CTSDprogramming participated in the susceptibility to osteoarthritis induced by prenatal dexamethasone exposure in male adult offspring rats
Abstract:Autophagy inhibition is known to be involved in the development of adult osteoarthritis. Dexamethasone, as a synthetic glucocorticoid, is widely used for premature delivery and related pregnancy diseases in clinics. We have previously shown that prenatal dexamethasone exposure (PDE) was associated with increased susceptibility to postnatal osteoarthritis in offspring. However, whether the occurrence of fetal-originated adult osteoarthritis induced by PDE is related to autophagy remains unclear. In this study, … Show more
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