2018
DOI: 10.1186/s13287-018-1073-0
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Abstract: Background/aimsMenstrual blood-derived endometrial stem cells (MenSCs) emerge as an ideal source for cell-based treatment in regenerative medicine and immunotherapy. However, the major obstacle is the low survival rate in tissues and the limited expansion number. Autophagy is an intracellular metabolic self-degradative process which plays important roles in normal cellular division and survival, and the present study aimed to explore the related mechanisms between autophagy and survival of MenSCs in vitro and … Show more

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Cited by 17 publications
(15 citation statements)
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References 37 publications
(34 reference statements)
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“…6e and f), indicating a compensatory effect for the decreased level of p-AKT Thr308 . Studies have shown that active GSK3β plays a proapoptosis role [52,54,[65][66][67], and that GSK3β can be inactivated when it is phosphorylated at Ser9 by AKT [68,69]. We found that although the total level of GSK3β was unchanged ( Fig.…”
Section: Decreased Activity Of Akt-gsk3β Signaling Pathway After Pdk1mentioning
confidence: 56%
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“…6e and f), indicating a compensatory effect for the decreased level of p-AKT Thr308 . Studies have shown that active GSK3β plays a proapoptosis role [52,54,[65][66][67], and that GSK3β can be inactivated when it is phosphorylated at Ser9 by AKT [68,69]. We found that although the total level of GSK3β was unchanged ( Fig.…”
Section: Decreased Activity Of Akt-gsk3β Signaling Pathway After Pdk1mentioning
confidence: 56%
“…Subsequently, the activity of GSK3β, a key downstream effector of the PDK1-AKT signaling pathway, was increased, as reflected by the decreased phosphorylation of GSK3β at Ser9. Studies have demonstrated that increased GSK3β activity enhances apoptosis [54,66,67]. Thus, the AKT-GSK3β signaling pathway may be involved in the regulation of the survival of interneurons.…”
Section: Discussionmentioning
confidence: 99%
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“…Autophagy is a kind of intracellular self digestion pathway, which is responsible for the removal of longlived proteins, damaged organelles and abnormal proteins during lysosomal biosynthesis [5]. Autophagy is a highly conserved biological process, which exists in eukaryotes and maintains cell homeostasis and viability by recycling and reusing energy [6,7]. Autophagy is usually considered as a protective mechanism of cells, and over autophagy will lead to autophagy cell death [8,9].…”
Section: Introductionmentioning
confidence: 99%