2016
DOI: 10.1080/15548627.2016.1247143
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Abstract: Macroautophagy/autophagy has profound implications for aging. However, the true features of autophagy in the progression of aging remain to be clarified. In the present study, we explored the status of autophagic flux during the development of cell senescence induced by oxidative stress. In this system, although autophagic structures increased, the degradation of SQSTM1/p62 protein, the yellow puncta of mRFP-GFP-LC3 fluorescence and the activity of lysosomal proteolytic enzymes all decreased in senescent cells… Show more

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Cited by 224 publications
(187 citation statements)
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References 51 publications
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“…The issue is further confused by the fact that autophagy is also suggested to prevent cellular senescence. Thus, it was shown that ROS can lead to perturbation of autophagic flux in senescent cells and restoration of flux can be achieved by AMPK activation . These conclusions seem to be consistent with the discussed above and well‐documented suppression of senescence by mTORC1 inhibitors which may, at least in part, act by autophagy upregulation .…”
Section: Autophagy In Senescencesupporting
confidence: 85%
See 1 more Smart Citation
“…The issue is further confused by the fact that autophagy is also suggested to prevent cellular senescence. Thus, it was shown that ROS can lead to perturbation of autophagic flux in senescent cells and restoration of flux can be achieved by AMPK activation . These conclusions seem to be consistent with the discussed above and well‐documented suppression of senescence by mTORC1 inhibitors which may, at least in part, act by autophagy upregulation .…”
Section: Autophagy In Senescencesupporting
confidence: 85%
“…Thus, it was shown that ROS can lead to perturbation of autophagic flux in senescent cells and restoration of flux can be achieved by AMPK activation . These conclusions seem to be consistent with the discussed above and well‐documented suppression of senescence by mTORC1 inhibitors which may, at least in part, act by autophagy upregulation . Similarly, recent reports suggest that autophagy can allow the bypass of RAS‐induced senescence and facilitate tumour growth .…”
Section: Autophagy In Senescencesupporting
confidence: 84%
“…The relationship between aging and autophagy has been established. For example, the expression of the autophagic‐related genes is strongly associated with lifespan regulation in flies and worms (Lionaki & Tavernarakis, ; Simonsen et al, ) and the activation of autophagy evoked by mTOR inhibitor rapamaycin extends lifespan in Drosophila (Kapahi et al, ), in addition, our previous study demonstrated that autophagy impairment is positively correlated with senescence development (Tai et al, ). For this reason, the restoration of autophagic flux is a reasonable consideration for anti‐aging/senescence therapeutics.…”
Section: Discussionmentioning
confidence: 99%
“…This is particularly prominent when cells are challenged with oxidative stress. Whereas oxidative stress normally activates autophagy, excessive oxidative stress has been shown to rather impair autophagic activity, eventually causing cellular senescence (Han et al, 2016; Tai et al, 2017). These observations are probably resulting from the balance act between the level of oxidative stress and the capacity of autophagy counteracting it.…”
Section: Autophagy As An Anti-senescence Mechanismmentioning
confidence: 99%
“…These observations are probably resulting from the balance act between the level of oxidative stress and the capacity of autophagy counteracting it. Enhancing or restoring autophagic activity under excessive oxidative stress by either AMPK activation or mTOR inhibition efficiently suppresses cellular senescence (Dalle Pezze et al, 2014; Han et al, 2016; Nopparat et al, 2017; Tai et al, 2017). These results are also supported by recent findings that melatonin enhances autophagic activity via the SIRT1 signaling pathway to suppress oxidative stress-induced senescence (Nopparat et al, 2017).…”
Section: Autophagy As An Anti-senescence Mechanismmentioning
confidence: 99%