2008
DOI: 10.1038/nature06639
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Abstract: Autophagy, or cellular self-digestion, is a cellular pathway involved in protein and organelle degradation, with an astonishing number of connections to human disease and physiology. For example, autophagic dysfunction is associated with cancer, neurodegeneration, microbial infection and ageing. Paradoxically, although autophagy is primarily a protective process for the cell, it can also play a role in cell death. Understanding autophagy may ultimately allow scientists and clinicians to harness this process fo… Show more

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Cited by 5,685 publications
(5,047 citation statements)
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References 59 publications
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“…Autophagy is a process in which cellular components such as proteins and damaged mitochondria are engulfed by autophagosomes and delivered to lysosomes to be degraded and recycled in order to maintain cellular homeostasis (Mizushima, Levine, Cuervo, & Klionsky, 2008). Autophagy has been widely studied as a mechanism for anti‐aging effects and in alleviating age‐related diseases (Rubinsztein, Marino, & Kroemer, 2011).…”
Section: Introductionmentioning
confidence: 99%
“…Autophagy is a process in which cellular components such as proteins and damaged mitochondria are engulfed by autophagosomes and delivered to lysosomes to be degraded and recycled in order to maintain cellular homeostasis (Mizushima, Levine, Cuervo, & Klionsky, 2008). Autophagy has been widely studied as a mechanism for anti‐aging effects and in alleviating age‐related diseases (Rubinsztein, Marino, & Kroemer, 2011).…”
Section: Introductionmentioning
confidence: 99%
“…Autophagy, a highly conserved cellular catabolic process for degradation and recycling of misfolded or damaged proteins and organelles,6 is considered to be a cytoprotective mechanism under most circumstances, although pathologically increased autophagy may lead to cell death 7. A large pool of evidence has demonstrated that autophagy activation is neuroprotective in ischemic stroke 8, 9, 10.…”
Section: Introductionmentioning
confidence: 99%
“…Autophagosomes migrate along acetylated microtubules to fuse with lysosomes to form autolysosomes in which substrates are degraded (Fig. 1H) (Mizushima et al ., 2008; Xie et al ., 2010). Fibronectin‐containing late endosome may also fuses with autophagosome to form amphisome, and then fuses with lysosome to form autolysosomes (Fig.…”
Section: Introductionmentioning
confidence: 99%