2013
DOI: 10.18632/aging.100549
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Abstract: Organismal lifespan has been the primary readout in aging research. However, how longevity genes control tissue-specific aging remains an open question. To examine the crosstalk between longevity programs and specific tissues during aging, biomarkers of organ-specific aging are urgently needed. Since the earliest signs of aging occur in the skin, we sought to examine skin aging in a genetically tractable model. Here we introduce a Drosophila model of skin aging. The epidermis undergoes a dramatic morphological… Show more

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Cited by 19 publications
(42 citation statements)
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References 47 publications
(66 reference statements)
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“…In addition, Atg7 appears dispensable for skin barrier formation in mice and flies. 66,67 This evidence predicts that impairment of autophagy does not cause the developmental alterations associated to CEDNIK at least in the skin, which have been fairly well characterized. 29,32,33 It is well possible that impaired autophagy plays a role in the unexplored neuronal traits of CEDNIK, considering that autophagy is a major process preventing neurodegeneration (for review see ref.…”
Section: Is Snap29 a Positive Regulator Of Membrane Fusion?mentioning
confidence: 94%
“…In addition, Atg7 appears dispensable for skin barrier formation in mice and flies. 66,67 This evidence predicts that impairment of autophagy does not cause the developmental alterations associated to CEDNIK at least in the skin, which have been fairly well characterized. 29,32,33 It is well possible that impaired autophagy plays a role in the unexplored neuronal traits of CEDNIK, considering that autophagy is a major process preventing neurodegeneration (for review see ref.…”
Section: Is Snap29 a Positive Regulator Of Membrane Fusion?mentioning
confidence: 94%
“…1 Interestingly, it was observed in the adult fly epidermis that epidermal cells spontaneously fuse as cells turnover during normal aging. 25 This demonstrates that cell fusion may be used to compensate for different types of tissue insults to preserve integrity.…”
Section: Wip Restores Tissue Mass and Integritymentioning
confidence: 97%
“…An alterative explanation is that autophagy might be toxic in the oldest animals, such as part of an autophagic cell death pathway. Intriguingly, inhibition of Atg7 by RNAi in adult fly epidermis delayed aging-related changes [276], suggesting that autophagy might contribute to aging of this tissue. Autophagy is also implicated in neuronal cell death during aging [277].…”
Section: The Autophagy/life Span Paradoxmentioning
confidence: 99%