2000
DOI: 10.1126/science.290.5497.1717
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Macroautophagy is a dynamic process involving the rearrangement of subcellular membranes to sequester cytoplasm and organelles for delivery to the lysosome or vacuole where the sequestered cargo is degraded and recycled. This process takes place in all eukaryotic cells. It is highly regulated through the action of various kinases, phosphatases, and guanosine triphosphatases (GTPases). The core protein machinery that is necessary to drive formation and consumption of intermediates in the macroautophagy pathway … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

32
2,523
2
30

Year Published

2002
2002
2018
2018

Publication Types

Select...
6
4

Relationship

0
10

Authors

Journals

citations
Cited by 3,195 publications
(2,587 citation statements)
references
References 84 publications
(69 reference statements)
32
2,523
2
30
Order By: Relevance
“…Autophagy is a lysosomal pathway that degrades various cellular components, including proteins and organelles, and is suppressed by mTORC1 signaling and upregulated in response to certain forms of stress, such as nutrient deprivation (Klionsky & Emr, 2000). Upregulation of autophagy would be expected to increase protein RRs, but we reproducibly measured a general reduction in hepatic proteome RRs in all three models.…”
Section: Discussionmentioning
confidence: 99%
“…Autophagy is a lysosomal pathway that degrades various cellular components, including proteins and organelles, and is suppressed by mTORC1 signaling and upregulated in response to certain forms of stress, such as nutrient deprivation (Klionsky & Emr, 2000). Upregulation of autophagy would be expected to increase protein RRs, but we reproducibly measured a general reduction in hepatic proteome RRs in all three models.…”
Section: Discussionmentioning
confidence: 99%
“…Autophagy plays an essential role in cellular metabolism and homeostasis by degrading both long‐lived cytoplasmic proteins and dysfunctional organelles via lysosome‐dependent machinery (Klionsky & Emr, 2000; Rautou et al., 2010). Recently, the potential involvement of autophagy in aging and aging‐associated organ injuries has become evident.…”
Section: Introductionmentioning
confidence: 99%
“…Autophagy is an evolutionarily conserved intracellular process that involves the formation of a double-membrane structure called the autophagosome. It delivers misfolded or long-lived cytoplasmic proteins and damaged organelles to lysosomes for degradation and recycling [9,10]. Currently, LC3 is widely used as a marker for monitoring autophagy [11,12].…”
Section: Introductionmentioning
confidence: 99%