Autonomic Performance and Dehydroepiandrosterone Sulfate Levels in HIV-1–Infected Individuals

Abstract

Our data show significant associations between markers of immune activation and disease progression and a composite measure of autonomic function in HIV-1-infected individuals. In addition, they suggest that poor autonomic function and low DHEAS plasma levels tend to be associated with an unbalanced cytokine profile.

Dehydroepiandrosterone replacement in patients with Addison's disease has a bimodal effect on regulatory (CD4+CD25hi and CD4+FoxP3+) T cells

“…If anything, endogenous human DHEA levels correlate with Th1 cytokines. In a study of 31 patients with HIV infection, there was a positive association between serum DHEAS levels and the amount of IFN‐γ (but not IL‐4) secreted by PBMC stimulated ex vivo with PHA 34. A similar result was obtained by following the changes in Th phenotype throughout the menstrual cycle: IL‐4‐secreting PBMC numbers correlated with oestrogen concentration, but the number of IFN‐γ‐secreting cells correlated with DHEAS levels 35.…”

Dehydroepiandrosterone replacement in patients with Addison's disease has a bimodal effect on regulatory (CD4+CD25hi and CD4+FoxP3+) T cells

“…If anything, endogenous human DHEA levels correlate with Th1 cytokines. In a study of 31 patients with HIV infection, there was a positive association between serum DHEAS levels and the amount of IFN‐γ (but not IL‐4) secreted by PBMC stimulated ex vivo with PHA 34. A similar result was obtained by following the changes in Th phenotype throughout the menstrual cycle: IL‐4‐secreting PBMC numbers correlated with oestrogen concentration, but the number of IFN‐γ‐secreting cells correlated with DHEAS levels 35.…”

Cardiovagal Autonomic Function in HIV-Infected Patients with Unsuppressed HIV Viremia

“…Markers of immune activation and disease progression correlate with severity of autonomic dysfunction. 36,37 …”

Altered Cortisol/DHEA Ratio in Tuberculosis Patients and its Relationship with Abnormalities in the Mycobacterial‐driven Cytokine Production by Peripheral Blood Mononuclear Cells

“…Recent studies among Ethiopians infected with Schistosoma mansoni demonstrated a significant negative correlation between serum levels of DHEA sulphate and intensity of infection [22]. Furthermore, a positive association between serum DHEAS levels and the amount of IFN‐ γ secreted by mitogen‐stimulated PBMC or the number of IFN‐ γ ‐secreting PBMC was also found in HIV patients or normal women respectively [23, 24]. Taken together, it is worth speculating that fluctuations in the mycobacterial‐driven in vitro responses may be partially explained by changes in adrenal steroids concentrations in plasma.…”

Dehydroepiandrosterone replacement in patients with Addison's disease has a bimodal effect on regulatory (CD4+CD25hi and CD4+FoxP3+) T cells

“…If anything, endogenous human DHEA levels correlate with Th1 cytokines. In a study of 31 patients with HIV infection, there was a positive association between serum DHEAS levels and the amount of IFN‐γ (but not IL‐4) secreted by PBMC stimulated ex vivo with PHA 34. A similar result was obtained by following the changes in Th phenotype throughout the menstrual cycle: IL‐4‐secreting PBMC numbers correlated with oestrogen concentration, but the number of IFN‐γ‐secreting cells correlated with DHEAS levels 35.…”

Cardiovagal Autonomic Function in HIV-Infected Patients with Unsuppressed HIV Viremia

“…Markers of immune activation and disease progression correlate with severity of autonomic dysfunction. 36,37 …”

Altered Cortisol/DHEA Ratio in Tuberculosis Patients and its Relationship with Abnormalities in the Mycobacterial‐driven Cytokine Production by Peripheral Blood Mononuclear Cells

“…Recent studies among Ethiopians infected with Schistosoma mansoni demonstrated a significant negative correlation between serum levels of DHEA sulphate and intensity of infection [22]. Furthermore, a positive association between serum DHEAS levels and the amount of IFN‐ γ secreted by mitogen‐stimulated PBMC or the number of IFN‐ γ ‐secreting PBMC was also found in HIV patients or normal women respectively [23, 24]. Taken together, it is worth speculating that fluctuations in the mycobacterial‐driven in vitro responses may be partially explained by changes in adrenal steroids concentrations in plasma.…”

Dehydroepiandrosterone replacement in patients with Addison's disease has a bimodal effect on regulatory (CD4+CD25hi and CD4+FoxP3+) T cells

“…If anything, endogenous human DHEA levels correlate with Th1 cytokines. In a study of 31 patients with HIV infection, there was a positive association between serum DHEAS levels and the amount of IFN‐γ (but not IL‐4) secreted by PBMC stimulated ex vivo with PHA 34. A similar result was obtained by following the changes in Th phenotype throughout the menstrual cycle: IL‐4‐secreting PBMC numbers correlated with oestrogen concentration, but the number of IFN‐γ‐secreting cells correlated with DHEAS levels 35.…”

Cardiovagal Autonomic Function in HIV-Infected Patients with Unsuppressed HIV Viremia

“…Markers of immune activation and disease progression correlate with severity of autonomic dysfunction. 36,37 …”

Altered Cortisol/DHEA Ratio in Tuberculosis Patients and its Relationship with Abnormalities in the Mycobacterial‐driven Cytokine Production by Peripheral Blood Mononuclear Cells

“…Recent studies among Ethiopians infected with Schistosoma mansoni demonstrated a significant negative correlation between serum levels of DHEA sulphate and intensity of infection [22]. Furthermore, a positive association between serum DHEAS levels and the amount of IFN‐ γ secreted by mitogen‐stimulated PBMC or the number of IFN‐ γ ‐secreting PBMC was also found in HIV patients or normal women respectively [23, 24]. Taken together, it is worth speculating that fluctuations in the mycobacterial‐driven in vitro responses may be partially explained by changes in adrenal steroids concentrations in plasma.…”