1983
DOI: 10.1152/ajpendo.1983.245.6.e542
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Abstract: We studied the autonomic nervous control of pancreatic somatostatin secretion using isolated perfused pig pancreases prepared with either intact vagal or splanchnic nerve supply. Electrical stimulation of the vagus nerves increased pancreatic protein output 59-fold, whereas somatostatin output decreased to 57% of prestimulatory secretion. Acetylcholine mimicked the somatostatin response to vagal stimulation, and atropine abolished the inhibition. Splanchnic nerve stimulation increased perfusion pressure up to … Show more

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Cited by 27 publications
(23 citation statements)
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“…A recent study in pigs has shown that electrical vagal stimulation inhibits the somatostatin release which is reversed in the presence of atropine and suggested that a cholinergic neuron has an inhibitory effect on pancreatic somatostatin secretion (13). In the present in vitro study, vagal stimulation produced an inhibition in pancreatic somatostatin release.…”
Section: Discussionsupporting
confidence: 57%
See 1 more Smart Citation
“…A recent study in pigs has shown that electrical vagal stimulation inhibits the somatostatin release which is reversed in the presence of atropine and suggested that a cholinergic neuron has an inhibitory effect on pancreatic somatostatin secretion (13). In the present in vitro study, vagal stimulation produced an inhibition in pancreatic somatostatin release.…”
Section: Discussionsupporting
confidence: 57%
“…On the other hand, the role of the vagus nerve in regulating somatostatin secretion from the pancreas has not been well studied. To our knowledge, there has been only a report (13) demonstrating an inhibition by vagal stimulation of somatostatin secretion from the isolated perfused pig pancreas prepared with an intact vagal supply. We have developed a new in vitro method in which the rat pancreas was isolated with intact vagus nerve fibers and perfused.…”
Section: Introductionmentioning
confidence: 99%
“…A 80% reduction in the number of nerve endings in direct contact with alpha-cells was noted type 1 diabetes BB rats [41] which could be responsible for an impaired glucagon regulation as well as reduced PP secretion. However, acetylcholine activates glucagon secretion from isolated pancreatic alpha cells [42,43], indicating that glucagonostatic effect of acetylcholine on the whole pancreas is due to a more complex mechanism, perhaps involving inhibition of somatostatin secretion [37,44]. Our data are in agreement with this conclusion since the plasma glucagon to PP concentration ratio increased during the meal test in AN+ patients while it remained low and steady under control in AN-patients.…”
Section: Neuropathy Hamperssupporting
confidence: 87%
“…Thus, glucagon and PP secretions are stimulated by sympathetic nerve activation [57±60, 70,71] whereas somatostatin secretion is inhibited [71,72]. The mechanism of the changes in the secretion of the other islet hormones after sympathetic nerve stimulation is less well characterised.…”
Section: Sympathetic Nervesmentioning
confidence: 99%