Autonomic and Peripheral Neuropathies in Patients With Chronic Alcoholism

Erectile dysfunction as a sentinel symptom of cardiovascular autonomic neuropathy in heavy drinkers

“…Indeed, our exclusion criteria are stricter compared to those in other studies, in which alcoholics with a variety of internistic diseases (liver disease and pancreatitis) were recruited, possibly resulting in an overestimation of the observed autonomic dysfunctions. This may also explain why a correlation between peripheral and autonomic involvement was not detected in our patients, compared to previous studies (Monforte et al, 1995).…”

Erectile dysfunction as a sentinel symptom of cardiovascular autonomic neuropathy in heavy drinkers

“…Indeed, our exclusion criteria are stricter compared to those in other studies, in which alcoholics with a variety of internistic diseases (liver disease and pancreatitis) were recruited, possibly resulting in an overestimation of the observed autonomic dysfunctions. This may also explain why a correlation between peripheral and autonomic involvement was not detected in our patients, compared to previous studies (Monforte et al, 1995).…”

Peripheral Neuropathy After Chronic Alcohol Exposure in Mice: Impact of sex, total intake and duration and alcohol metabolism

“…Regardless, when comparing these studies to our results, it is important to highlight the lack of female animals and the use of different peripheral nerves for the electrophysiology studies. Most importantly, their studies highlight the translatable relevance of our mouse model which produced results most similar to clinical electrophysiological data showing changes in amplitude due axonal loss in small and large fibers and denervation (Julian et al, 2019; Koike & Sobue, 2006; Maiya & Messing, 2014; Monforte et al, 1995; Navarro et al, 1993; Papantoniou et al, 2024; Tessitore et al, 2022).…”

Is there a relationship between somatic and autonomic neuropathies in chronic alcoholics?

“…In addition, no significant statistical correlation was found between indices of somatic and autonomic neuropathy. Our findings do not support the existence of a parallel involvement of peripheral somatic and autonomic cardiovascular nerve fibers in chronic alcoholism [6,7]. The present data are in accordance with recent papers about other metabolic disturbances, such as uremia and diabetes.…”

Erectile dysfunction as a sentinel symptom of cardiovascular autonomic neuropathy in heavy drinkers

“…Indeed, our exclusion criteria are stricter compared to those in other studies, in which alcoholics with a variety of internistic diseases (liver disease and pancreatitis) were recruited, possibly resulting in an overestimation of the observed autonomic dysfunctions. This may also explain why a correlation between peripheral and autonomic involvement was not detected in our patients, compared to previous studies (Monforte et al, 1995).…”

Peripheral Neuropathy After Chronic Alcohol Exposure in Mice: Impact of sex, total intake and duration and alcohol metabolism

“…Regardless, when comparing these studies to our results, it is important to highlight the lack of female animals and the use of different peripheral nerves for the electrophysiology studies. Most importantly, their studies highlight the translatable relevance of our mouse model which produced results most similar to clinical electrophysiological data showing changes in amplitude due axonal loss in small and large fibers and denervation (Julian et al, 2019; Koike & Sobue, 2006; Maiya & Messing, 2014; Monforte et al, 1995; Navarro et al, 1993; Papantoniou et al, 2024; Tessitore et al, 2022).…”

Is there a relationship between somatic and autonomic neuropathies in chronic alcoholics?

“…In addition, no significant statistical correlation was found between indices of somatic and autonomic neuropathy. Our findings do not support the existence of a parallel involvement of peripheral somatic and autonomic cardiovascular nerve fibers in chronic alcoholism [6,7]. The present data are in accordance with recent papers about other metabolic disturbances, such as uremia and diabetes.…”

Erectile dysfunction as a sentinel symptom of cardiovascular autonomic neuropathy in heavy drinkers

“…Indeed, our exclusion criteria are stricter compared to those in other studies, in which alcoholics with a variety of internistic diseases (liver disease and pancreatitis) were recruited, possibly resulting in an overestimation of the observed autonomic dysfunctions. This may also explain why a correlation between peripheral and autonomic involvement was not detected in our patients, compared to previous studies (Monforte et al, 1995).…”

Peripheral Neuropathy After Chronic Alcohol Exposure in Mice: Impact of sex, total intake and duration and alcohol metabolism

“…Regardless, when comparing these studies to our results, it is important to highlight the lack of female animals and the use of different peripheral nerves for the electrophysiology studies. Most importantly, their studies highlight the translatable relevance of our mouse model which produced results most similar to clinical electrophysiological data showing changes in amplitude due axonal loss in small and large fibers and denervation (Julian et al, 2019; Koike & Sobue, 2006; Maiya & Messing, 2014; Monforte et al, 1995; Navarro et al, 1993; Papantoniou et al, 2024; Tessitore et al, 2022).…”

Is there a relationship between somatic and autonomic neuropathies in chronic alcoholics?

“…In addition, no significant statistical correlation was found between indices of somatic and autonomic neuropathy. Our findings do not support the existence of a parallel involvement of peripheral somatic and autonomic cardiovascular nerve fibers in chronic alcoholism [6,7]. The present data are in accordance with recent papers about other metabolic disturbances, such as uremia and diabetes.…”