Automated rectilinear self‐gated cardiac cine imaging

Crowe, Mark E.; Larson, Andrew C.; Zhang, Qiang; Carr, James C.; White, Richard D.; Li, Debiao; Simonetti, Orlando P.

doi:10.1002/mrm.20212

Cited by 115 publications

(120 citation statements)

References 12 publications

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“…Furthermore, the voltages induced in the ECG units by switching gradients (2,3) and the magnetohydrodynamic effect (4-6) make the measurement of an ECG signal difficult. To avoid these problems, physiological gating information can be extracted from the variations in the magnetic resonance (MR) signal itself (7,8). This so-called self-gating (SG) requires the incorporation of an additional data acquisition into the pulse sequence, which samples the integrated MR signal in the imaging slice.…”

mentioning

confidence: 99%

Optically detunable, inductively coupled coil for self‐gating in small animal magnetic resonance imaging

Korn

Umathum

Schulz

et al. 2010

Magnetic Resonance in Med

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An inductively coupled coil concept is presented, which improves the compensation of physiological motion by the self-gating (SG) technique. The animal is positioned in a conventional volume coil encompassing the whole animal. A small, resonant surface coil (SG-coil) is placed on the thorax so that its sensitive region includes the heart. Via inductive coupling the SG-coil amplifies selectively the MR signal of the beating heart. With an optical detuning mechanism, this coupling can be switched off during acquisition of the MR image information, whereas it is active during SG data sampling to provide the physiological information. In vivo experiments on a mouse show an amplification of the SG signal by at least 40%. Magn Reson Med 65:882-888,

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mentioning

confidence: 99%

Optically detunable, inductively coupled coil for self‐gating in small animal magnetic resonance imaging

Korn

Umathum

Schulz

et al. 2010

Magnetic Resonance in Med

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show abstract

“…This is attributed in part to the relatively strong gating signal of the TrueFISP sequence used in this demonstration. TR may be reduced by implementing the short second echo technique described by Crowe et al (6) to increase the number of image/navigator pairs that are acquired per cardiac cycle. Note that flexibility in cine reconstruction is a virtue of retrospective gating strategies: a finer reordering scheme could be used to reconstruct a greater number of frames with less signal averaging, reducing potential error in selection of end-systolic and enddiastolic frames when quantitative measures such as ejection fraction are required.…”

Section: Discussionmentioning

confidence: 99%

“…Because of the increased acquisition time required by this technique, Larson et al (5) developed a radial k-space sampling method that avoided the acquisition of extra gating data by extracting the motion synchronization signal directly from imaging data. A short second echo method by Crowe et al (6) further optimized acquisition efficiency by using a conventional rectilinear sampling scheme that required only a slight increase in pulse repetition time (TR). Although these pulse sequences were developed to increase the acquisition efficiency in human imaging, they can also be adapted for small animal imaging (7) and substantially enhance CMRI in mice.…”

mentioning

confidence: 99%

Wireless self‐gated multiple‐mouse cardiac cine MRI

Esparza‐Coss

Ramirez

Bankson

2008

Magnetic Resonance in Med

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Despite the excellent image-contrast capability of MRI and the ability to synchronize MRI with the murine cardiac cycle, this technique is underused for assessing mouse models of cardiovascular disease because of its perceived cost and complexity. This perception stems, in part, from complications associated with the placement and adjustment of electrocardiographic leads that may interact with gradient pulses and the relatively long acquisition times required with traditional gating schemes. To improve the efficiency and reduce the cost and complexity of using cardiac MRI in mice, we combined wireless self-gating techniques (with which we derived cardiac synchronization signals from acquired data) with an imaging technique that acquires multislice cardiac cine images from four mice simultaneously. As a result, the wireless self-gated acquisitions minimized animal preparation time and improved image quality. The simultaneous acquisition of cardiac cine data from multiple animals greatly increased throughput and reduced costs associated with instrument access. More people die annually from cardiovascular disease (CVD) than from any other cause. It accounts for 1 of every 3.4 deaths globally and one of every 2.8 deaths in the United States (1,2). Small-animal models of CVD are often employed for the evaluation of novel diagnostic and therapeutic approaches to improve our understanding and treatment of disease. Noninvasive, imaging-based assessment of cardiac structure and function improves observational power by allowing disease or injury and response to therapy to be tracked longitudinally without requiring sacrifice at each observation. MRI, as one of such valuable diagnostic tools, can provide good image contrast between myocardium and blood.The potential applicability of MRI-based investigations of small animal models of CVD is reduced because of cost and experimental complexity. Delays associated with the setup of electrocardiographic (ECG) equipment and the inefficient duty cycle of ECG-gated acquisitions limits the utility of traditional prospectively gated cardiac MRI (CMRI). Additionally, the use of metallic ECG leads introduces susceptibility artifacts and can pose problems with coupling to RF and gradient pulses that may distort the anatomy of interest, especially in small-animal investigations (3).Self-gated (SG) imaging techniques allow cardiac phases to be identified from MR data, eliminating the need for ECG signals and systems. The first SG method, described by Spraggins (4), involved a rectilinear double-slice/double-echo pulse sequence, and gating data were obtained through a second readout navigator that was not phaseencoded. Because of the increased acquisition time required by this technique, Larson et al. (5) developed a radial k-space sampling method that avoided the acquisition of extra gating data by extracting the motion synchronization signal directly from imaging data. A short second echo method by Crowe et al. (6) further optimized acquisition efficiency by using a conventional rectilin...

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“…The non-wireless based methods have some advantages but also suffer from increased acquisition time, limited visual access and extended reconstruction times, respectively [1][2][3][4][5][6][7][8][9][10][11]. This feasibility study measured 3D motion in real time using a wireless accelerometer to provide correction data for single angle, in-plane rotations which are common in neonatal imaging and difficult to correct with MR based navigator techniques.…”

Section: Introductionmentioning

confidence: 99%

Wireless Accelerometer for Neonatal MRI Motion Artifact Correction

et al. 2017

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Abstract:A wireless accelerometer has been used in conjunction with a dedicated 3T neonatal MRI system installed on a Neonatal Intensive Care Unit to measure in-plane rotation which is a common problem with neonatal MRI. Rotational data has been acquired in real-time from phantoms simultaneously with MR images which shows that the wireless accelerometer can be used in close proximity to the MR system. No artifacts were observed on the MR images from the accelerometer or from the MR system on the accelerometer output. Initial attempts to correct the raw data using the measured rotational angles have been performed, but further work will be required to make a robust correction algorithm.

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Automated rectilinear self‐gated cardiac cine imaging

Cited by 115 publications

References 12 publications

Optically detunable, inductively coupled coil for self‐gating in small animal magnetic resonance imaging

Optically detunable, inductively coupled coil for self‐gating in small animal magnetic resonance imaging

Wireless self‐gated multiple‐mouse cardiac cine MRI

Wireless Accelerometer for Neonatal MRI Motion Artifact Correction

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