Automated Multiphasic Health Testing

Collen, Morris F.

doi:10.1007/978-1-4612-5218-4_28

Cited by 28 publications

(38 citation statements)

References 1 publication

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“…14,15 Serum cholesterol was measured with an AutoAnalyzer (Technicon, White Plains, N.Y.) from 1964 through 1968, with an Autochemist (AGA, Stockholm, Sweden) from 1969 through 1972, and with an AutoAnalyzer (model SMA-12, Technicon) in 1973. Self-reported alcohol consumption during the previous year was categorized as follows: no alcoholic drinks, one or two drinks per day, three to five drinks per day, and six or more drinks per day.…”

Section: Discussionmentioning

confidence: 99%

Effect of Cigar Smoking on the Risk of Cardiovascular Disease, Chronic Obstructive Pulmonary Disease, and Cancer in Men

et al. 1999

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Section: Discussionmentioning

confidence: 99%

Effect of Cigar Smoking on the Risk of Cardiovascular Disease, Chronic Obstructive Pulmonary Disease, and Cancer in Men

et al. 1999

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“…The source population was a well-characterized, populationbased cohort of about 123 000 individuals receiving care within Kaiser Permanente of Northern California (KPNC), who participated in the Multiphasic Health Checkups (MHC) in the Oakland and San Francisco medical centers between 1964 and 1969, which included collection of several tubes of blood after at least 4 hours of fasting. 9 KPNC is a large, integrated healthcare delivery system that provides care for about one-third of the insured adult population in the greater San Francisco Bay Area. KPNC members are representative of the demographic and clinical aspects of the surrounding local and state population with the exception of the low and high segments of the income distribution.…”

Section: Study Population and Designmentioning

confidence: 99%

Does the association between serum endostatin, an endogenous anti-angiogenic protein, and acute myocardial infarction differ by race?

et al. 2006

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Abstract:Endostatin, an endogenous anti-angiogenic protein, has been linked to reduced atherosclerosis in animal models. We conducted a nested case-control study to ascertain whether decreased circulating endostatin might be associated with increased odds of acute myocardial infarction (AMI) and whether this association varied by sex or race. Cases were 211 subjects who subsequently developed AMI, and controls were 173 subjects free of cardiovascular disease matched on age, sex, race and follow-up time. In conditional logistic regression adjusting for traditional risk factors, the odds ratio of AMI per 1 SD increment in endostatin was 0.85 (95% confidence interval, 0.73-1.00). This association varied by race (but not by sex) such that a statistically significant inverse relation was found among Asians and white individuals and a significant positive relation among black individuals. Further research is needed to replicate these findings and to elucidate potential mechanisms for these race/ethnic differences.

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“…26,27 Body mass index was estimated as weight (in kilograms) divided by height (in meters squared) and weight gain as measured weight at the multiphasic checkup minus self-reported least weight since age 20. Medical conditions of interest included personal history of hyperthyroidism, hypothyroidism, goiter and treatment of tonsils or the neck region with X-rays (though no information was collected on radiation dose or age at the time of treatment).…”

Section: Study Design and Proceduresmentioning

confidence: 99%

Cohort study of thyroid cancer in a San Francisco Bay area population

et al. 2001

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Using data from a large health plan, we performed a cohort study of thyroid cancer among 204,964 persons (aged 10 -89 at baseline in 1964 -1973, 54% female) followed for a median of 20 years. Thyroid carcinoma is rare, representing 0.5% of cancers among U.S. men and 1.7% cancers among U.S. women, but remains the most common malignancy of the endocrine system. 1 Its incidence increased from 1987 to 1991 in the United States, 2 is greater in women than in men and peaks between the ages of 25 and 65. 3,4 The prognosis of well-differentiated, localized thyroid tumors is extremely good. 1 Persons considered to be at high risk include those with a history of radiation treatment during infancy and childhood, 5,6 those with exposure to nuclear testing 7 or to nuclear reactor accidents 8 and those with benign conditions of the thyroid gland. 9 -13 Other putative determinants include diet (notably iodine deficiency or excess), 14,15 hormonal, reproductive 16 -20 and genetic factors. 21,22 Other less well-studied potential risk factors include smoking, alcohol intake, 23 body size and weight gain. 18,24 In this report, we evaluated several potential predictors of thyroid cancer (including demographic, behavioral, medical and reproductive factors as well as occupational exposures) in a large, well-defined, multi-ethnic cohort of men and women enrolled in a health-maintenance organization (HMO) in northern California and followed for up to 33 years. MATERIAL AND METHODS Study design and proceduresWe used a historical cohort study design with measurement of characteristics at baseline (1964 -1973) and prospective follow-up of events from baseline through the end of 1997. The cohort was composed of 95,058 male and 112,838 female subscribers of the Kaiser Permanente Medical Care Program of Northern California, aged 10 -89, who underwent multiphasic health checkups between 1964 and 1973 in San Francisco or Oakland. Of the original cohort, 28 women and 6 men were excluded for having a prior diagnosis of thyroid cancer before the multiphasic checkup. An additional 2,395 women and 503 men were excluded for having a self-reported history of thyroid operation (though the extent of surgical removal was unknown). Thus, the final sample of persons free of thyroid cancer and with an intact thyroid gland consisted of 94,549 men and 110,415 women.Northern California Kaiser Permanente members constitute an ethnic and socio-economic mix that is generally representative of the local population, except that the extremes of wealth and poverty are under-represented. 25 If study participants attended more than 1 checkup, only the data from the first were used.The multiphasic checkup collected information on several demographic factors (age, gender, race/ethnicity and educational attainment), anthropometric measurements, health behaviors (cigarette smoking and alcohol consumption), physiological characteristics (including reproductive factors), medical conditions and occupational exposures using standardized instruments and procedures previously...

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Automated Multiphasic Health Testing

Cited by 28 publications

References 1 publication

Effect of Cigar Smoking on the Risk of Cardiovascular Disease, Chronic Obstructive Pulmonary Disease, and Cancer in Men

Effect of Cigar Smoking on the Risk of Cardiovascular Disease, Chronic Obstructive Pulmonary Disease, and Cancer in Men

Does the association between serum endostatin, an endogenous anti-angiogenic protein, and acute myocardial infarction differ by race?

Cohort study of thyroid cancer in a San Francisco Bay area population

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